Indiana is currently home to 1224 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Indianapolis, South Bend, Fort Wayne and Evansville. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread
NCT03547973
Recruiting
The objective of this study is to evaluate the efficacy and safety of sacituzumab govitecan-hziy monotherapy and with novel combinations in participants with metastatic urothelial cancer (mUC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Conditions: Metastatic Urothelial Cancer
Register for Updates
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
NCT05489705
Recruiting
This registry evaluates patient characteristics, real-world treatment patterns, and short- and long-term outcomes in a population of patients in the United States and Europe with symptomatic obstructive hypertrophic cardiomyopathy (HCM) who are receiving mavacamten, receiving other treatment for obstructive HCM, or not receiving treatment for obstructive HCM due to intolerance or failure of prior treatment. United States Sub-Study: The purpose of this study is to evaluate the safety of mavacamt... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Indiana. University, Indianapolis, Indiana
Conditions: Obstructive Hypertrophic Cardiomyopathy
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An Observational Study of Carbaglu® for the Treatment of MMA and PA in Adults and Pediatrics
NCT05040178
Recruiting
To obtain short-term and long-term clinical safety information, in pediatric and adult patients with PA and MMA treated with Carbaglu®.
Gender:
ALL
Ages:
All
Trial Updated:
04/10/2025
Locations: Riley Children's Hospital, Indianapolis, Indiana
Conditions: Hyperammonemia, Methylmalonic Acidemia, Propionic Acidemia
Register for Updates
Ultrasound Acute Chest Syndrome Sickle Cell Disease
NCT06880679
Recruiting
Feasibility and reliability of ultrasound in the inpatient hematology setting.
Gender:
ALL
Ages:
25 years and below
Trial Updated:
04/09/2025
Locations: Indiana University, Indianapolis, Indiana
Conditions: Acute Chest Syndrome, Sickle Cell Disease
Register for Updates
An Open-label, Single-arm Study to Evaluate Pharmacokinetics and Safety of Subcutaneous Sonelokimab in Adolescents With Moderate to Severe Hidradenitis Suppurativa (VELA-TEEN)
NCT06768671
Recruiting
This is a study to evaluate the pharmacokinetic (PK) and safety of sonelokimab in adolescent patients with HS.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
04/09/2025
Locations: Clinical Site, Columbus, Indiana
Conditions: Hidradenitis Suppurativa
Register for Updates
A Study of VET3-TGI in Patients With Solid Tumors
NCT06444815
Recruiting
VET3-TGI is an oncolytic immunotherapy designed to treat advanced cancers. VET3-TGI has not been given to human patients yet, and the current study is designed to find a safe and effective dose of VET3-TGI when administered by direct injection into tumor(s) (called an intratumoral injection) or when given intravenously (into the vein) both alone and in combination with pembrolizumab in patients with solid tumors (STEALTH-001).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Community Health Network, Indianapolis, Indiana
Conditions: Solid Tumor, Adult, Microsatellite Stable Colorectal Cancer, Head and Neck Squamous Cell Carcinoma, Cervical Cancer, Kidney Cancer, Renal Cell Carcinoma, Melanoma Stage IV, Merkel Cell Carcinoma of Skin, Mesothelioma, Non-small Cell Lung Cancer
Register for Updates
A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC
NCT06246110
Recruiting
This study is for patients with advanced/metastatic non-small cells lung cancer (NSCLC) who have not received any treatment through the vein for the advanced disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Indiana University Cancer Center, Indianapolis, Indiana
Conditions: NSCLC
Register for Updates
Umbrella Study for Analysis of Data Related to Patients With Cancer
NCT06018753
Recruiting
This study is a multisite, minimal risk, non-interventional study using patient electronic health record data collected as part of standard of care to answer cohort-based research questions and create robust real-world data sets.
Gender:
ALL
Ages:
All
Trial Updated:
04/09/2025
Locations: Community Health Network, Indianapolis, Indiana
Conditions: Cancer
Register for Updates
Type 1 Diabetes Extension Study
NCT02734277
Recruiting
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study will: * follow participants to determine how long they continue to produce insulin, and * will also assess how changes in the immune system over time relate to the ability to produce insulin. This information could help design better therapies for... Read More
Gender:
ALL
Ages:
Between 8 years and 35 years
Trial Updated:
04/09/2025
Locations: Indiana University Riley Hospital for Children, Indianapolis, Indiana
Conditions: Type 1 Diabetes Mellitus, T1DM, T1D
Register for Updates
Molecular Mechanisms Associated With Breast Implant Complications
NCT05736354
Recruiting
Bacterial biofilms cause implant failures, chronic inflammation, and immune polarization. The study investigates the possible role of bacterial biofilm as a factor in the etiology of Breast Implant Illness. Three patient cohorts will be studied (A) Subjects with breast implant with BII manifestations (B) Subjects with breast implants without BII manifestations (C) Subjects without breast implants who underwent breast surgery procedure. Blood, surgically discarded tissue, implants, and associated... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: IU Health North Hospital, Carmel, Indiana
Conditions: Breast Implant; Complications, Infection or Inflammation
Register for Updates
The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis
NCT05564936
Recruiting
ME\&MG is a standalone software (digital solution) running on patients smartphones, connected to a web portal for physicians. It is intended to be used as an unsupervised digital self-assessment tool for the monitoring of disabilities in patients living with MG. ME\&MG contains digital active tests for the assessment of ptosis, breathing, dysarthria, upper- and lower-limb (arms and legs) weakness, treatment follow-up, and validated e-questionnaires related to daily activities, pain, fatigue, sl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: HealthParterns Institute, Bloomington, Indiana
Conditions: Myasthenia Gravis
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Survivorship Plan HEalth REcord (SPHERE) Implementation Trial
NCT05346796
Recruiting
To understand the effectiveness and implementation of the SCP-PHR, we will conduct a hybrid type 1 effectiveness-implementation trial consisting of the following components: (A) a randomized clinical effectiveness trial, and (B) a mixed methods implementation study.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
04/08/2025
Locations: Indiana University School of Medicine, Indianapolis, Indiana
Conditions: Cancer
Register for Updates