Iowa is currently home to 818 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and Cedar Rapids. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of ASP2074 in Adults With Solid Tumors
Recruiting
ASP2074 is a potential new treatment for people with certain solid tumors. Before ASP2074 is available as a treatment, the researchers need to understand how it is processed by and acts upon the body. This information will help find a suitable dose and check for potential medical problems from the treatment. People in this study will be adults with metastatic or locally advanced solid tumors. Metastatic means the cancer has spread to other parts of the body. They will have been previously treate... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2024
Locations: University of Iowa Hospitals, Iowa City, Iowa
Conditions: Advanced Solid Tumors
A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)
Recruiting
B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma (DLBCL). Change in disease activity will be assessed. Epcoritamab is an... Read More
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
03/25/2024
Locations: Mission Cancer and Blood /ID# 261945, Des Moines, Iowa
Conditions: Diffuse Large B-Cell Lymphoma
Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
Recruiting
This pilot study will collect preliminary data that measures the effects of psilocybin-assisted psychotherapy vs ketamine-assisted psychotherapy on patients struggling with alcohol use.
Gender:
Male
Ages:
Between 25 years and 50 years
Trial Updated:
03/25/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Alcohol Use Disorder
A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
Recruiting
The study compares two medicines for treatment of children born small and who stay small, or with Turner Syndrome, Noonan Syndrome, or idiopathic short stature. The purpose of the study is to see how well treatment with somapacitan works compared to treatment with Norditropin®. Somapacitan is a new medicine, and Norditropin® is a medicine doctors can already prescribe in some countries. The study will last for about 3 years. The participants will either get somapacitan once a week for 3 years or... Read More
Gender:
All
Ages:
Between 2 years and 10 years
Trial Updated:
03/25/2024
Locations: University OF Iowa, Iowa City, Iowa
Conditions: SGA, Turner Syndrome, Noonan Syndrome, ISS
A Research Study Looking at Mim8 in Children With Haemophilia A With or Without Inhibitors
Recruiting
This study is looking at how Mim8 works compared to other medicines in children with haemophilia A, who either have inhibitors or do not have inhibitors. Mim8 is a new medicine that will be used for prevention of bleeds. Mim8 will be injected with a thin needle into the skin. The study will last for about 54-98 weeks, from screening to follow-up visit, In case the participant experiences bleeds, these can be treated with additional haemostatic medicine as agreed with the study doctor.
Gender:
All
Ages:
Between 1 year and 11 years
Trial Updated:
03/25/2024
Locations: University of Iowa_Iowa City, Iowa City, Iowa
Conditions: Haemophilia A With or Without Inhibitors
Intraperitoneal Paclitaxel-loaded TPM for Treatment of Peritoneal Carcinomatosis
Recruiting
A first-in-human, unblinded, phase I trial of Paclitaxel-loaded tumor penetrating microparticles (TPM) in peritoneal carcinomatosis patients who are not eligible for standard-of-care therapeutic interventions.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/25/2024
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: Peritoneal Carcinomatosis
Registry of Arthrex Hand and Wrist Products
Recruiting
A Multi-Center, Prospective Registry to Evaluate the Continued Safety and Effectiveness of Hand and Wrist Products
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Ulnar/Radial Collateral Ligament Reconstruction, Ligament Repair or Reconstruction, Small Bone Fragments and Arthrodesis, Scapholunate Ligament Reconstruction, Carpal Fusion (Arthrodesis) of the Hand, Digital Tendon Transfers, Carpometacarpal Joint Arthroplasty
SPIROMICS Study of Early COPD Progression (SOURCE)
Recruiting
This is an observational study of 1000 participants to further define the nature of early chronic obstructive pulmonary disease (COPD) in younger, at-risk individuals. The study has three main goals: To use CT scan imaging to identify which smokers will develop COPD. To identify biomarkers predictive of smokers that will develop COPD. To determine if sputum (phlegm) can be analyzed to predict which smokers will develop COPD. Procedures (methods): All participants will undergo study related qu... Read More
Gender:
All
Ages:
Between 30 years and 55 years
Trial Updated:
03/25/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: COPD, Early-Onset
Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Giant Cell Arteritis (GCA)
Recruiting
This is a phase III study of efficacy and safety of secukinumab versus placebo, in combination with glucocorticoid taper regimen, in patients with giant cell arteritis (GCA)
Gender:
All
Ages:
50 years and above
Trial Updated:
03/25/2024
Locations: Novartis Investigative Site, Iowa City, Iowa
Conditions: Giant Cell Arteritis (GCA)
Fenofibrate for Prevention of DR Worsening
Recruiting
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME at baseline. In addition to evaluating efficacy, this study aims to evaluate the feasibility of a model for ophthalmologists to prescribe or collaborate with a primary care provider such as an internist/endocrinologist to prescribe and monitor the dru... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/25/2024
Locations: Wolfe Eye Clinic-Cedar Rapids, Hiawatha, Iowa
Conditions: Diabetic Retinopathy
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Recruiting
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
03/25/2024
Locations: Meridian Clinical Research, LLC, Sioux City, Iowa
Conditions: Pediatric Migraine
Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure
Recruiting
The ALLEVIATE-HF study is a prospective, randomized, controlled, blinded, multi-site, interventional, investigational device exemption (IDE) pivotal study. The purpose of the study is to demonstrate the safety and efficacy of a patient management pathway that utilizes an integrated device diagnostic-based risk stratification algorithm to guide patient care in subjects with NYHA class II and III heart failure, and to demonstrate the safety of the Reveal LINQ™ system and procedure in the study pop... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2024
Locations: Iowa Heart Center, West Des Moines, Iowa
Conditions: Heart Failure NYHA Class II, Heart Failure NYHA Class III