There are currently 1271 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer
NCT06315491
Recruiting
The purpose of this study is to assess the safety, tolerability, and efficacy of CBX-12 in female subjects with platinum resistant or refractory ovarian cancer at 2 doses; 125 mg/m2 every 21 days or 100 mg/m2 every 21 days.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University Hospitals Seidman Cancer Center, Cleveland, Ohio
Conditions: Platinum-resistant Ovarian Cancer, Refractory Ovarian Carcinoma
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Quantra Point-of-Care Hemostasis Monitoring
NCT06328647
Recruiting
The investigators will test the hypothesis that utilization of a blood and blood component transfusion algorithm guided by the POC Quantra QPlus System in patients undergoing complex cardiac surgery will reduce RBC, plasma, cryoprecipitate, and platelet transfusion during surgery and the first 12 postoperative hours, compared to standard of care (central laboratory transfusion monitoring at the primary anesthesia provider's discretion).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Bleeding, Hemostatic Disorder
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Antigen Specific Adoptive T Cell Therapy for Adenovirus Infection After Hematopoietic Stem Cell Transplantation
NCT03378102
Recruiting
The purpose of this study is to determine if it is possible to treat an infection with a cell-based immunotherapy (therapy that uses the patient's own immune system to treat the infection). This treatment is called adoptive T cell therapy. Another purpose is to learn about the side effects and toxicities of adoptive T cell therapy. Adoptive T cell therapy is an investigational (experimental) therapy that works by using the blood of a donor that has immunity against the virus. The donor cells ar... Read More
Gender:
ALL
Ages:
3 months and above
Trial Updated:
03/10/2025
Locations: University Hospitals, Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation
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Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry
NCT05196061
Recruiting
Bacterial and fungal microbiota will be different between individual body sites; however, particular microbiome profiles both whole-body and site-specific will be unique to volunteers with a given parameter such as medical diagnosis, diet, medications taken, geographical area; etc.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/10/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Healthy Volunteers
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A Phase I Study of IAG933 in Patients With Advanced Mesothelioma and Other Solid Tumors
NCT04857372
Recruiting
The purpose of this study is to characterize the safety and tolerability of IAG933 in patients with mesothelioma, NF2/LATS1/LATS2 mutated tumors and tumors with functional YAP/TAZ fusions and to identify the maximum tolerated dose and/or recommended dose.
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
03/07/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Mesothelioma
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Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer
NCT04612751
Recruiting
This study will assess safety, tolerability, and treatment activity of datopotamab deruxtecan (Dato-DXd) in combination with immunotherapy with or without carboplatin in participants with advanced or metastatic non-small cell lung cancer (NSCLC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Research Site, Cleveland, Ohio
Conditions: Advanced or Metastatic NSCLC
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Study Of ATRN-119 In Patients With Advanced Solid Tumors
NCT04905914
Recruiting
The purpose of this study is to assess the safety and effectiveness of ATRN-119 through the performance of a Phase 1/2a, open-label, safety, PK, and preliminary efficacy study of oral ATRN-119 in patients with advanced solid tumors.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
03/06/2025
Locations: University Hospitals, Cleveland Medical Center, Cleveland, Ohio
Conditions: Advanced Solid Tumor
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Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr
NCT05948657
Recruiting
This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.
Gender:
MALE
Ages:
Between 18 years and 90 years
Trial Updated:
03/06/2025
Locations: Case Western University Hospitals, Cleveland, Ohio
Conditions: Prostate Cancer
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Prism Adaptation Therapy (PAT) for Right Brain Stroke Rehabilitation
NCT05983185
Recruiting
After a right brain stroke, \>50% of Veterans experience problems with dressing, eating, self-care or steering their wheelchairs because their ability to move, orient, and respond toward the left side is limited: spatial neglect. Spatial neglect prevents them from functioning independently, and their needs in the hospital and at home are greatly increased. An effective treatment for spatial neglect is 10 days of visuomotor training while wearing optical prisms (PAT), however many clinicians \[fa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
Conditions: Spatial Neglect After Right Brain Stroke
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The Management of Necrotizing Soft Tissue Infection Wounds with Cytal® Wound Matrix and MicroMatrix®
NCT06857708
Recruiting
This is a prospective, pilot, parallel group, randomized controlled trial with 1:1 allocation. This will be a single center study coordinated at the Cleveland Clinic Foundation (CCF) Main Campus in Cleveland, Ohio. Data will be collected in a secure manner using REDCap housed at CCF. The study will consist of 2 arms: treatment with Cytal® Wound Matrix 2-Layer and MicroMatrix® (Integra LifeSciences, Plainsboro Township, NJ, U.S.A.) versus standard of care dressings. Wound debridement procedures w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Necrotizing Fascitis, Necrotizing Soft Tissue Infection
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Proton Therapy Patient Registry
NCT02986048
Recruiting
The purpose of this study is to establish a database (or "registry") of patients treated with proton beam therapy at the University Hospitals (UH) Proton Therapy Center. By keeping track of the patients treated it will allow the investigators to periodically evaluate the outcomes of patients.
Gender:
ALL
Ages:
All
Trial Updated:
03/05/2025
Locations: University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Treatment With Proton Beam Radiation Therapy
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Open-Label Pilot Study With Crofelemer in Patients With Short Bowel Syndrome
NCT06326645
Recruiting
The objectives of this study are to evaluate the efficacy and safety of crofelemer treatment in adults affected by Short Bowel Syndrome (SBS) with an ileostomy on parenteral support (PS) in reducing output or PS needs. Crofelemer will be provided as a powder three times daily for 12 weeks and a 4 week follow up. .
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: Cleveland Clinic Main Campus, Cleveland, Ohio
Conditions: Short Bowel Syndrome
Register for Updates