There are currently 1278 clinical trials in Cleveland, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cleveland Clinic, Cleveland Clinic Foundation, Case Western Reserve University and University Hospitals Cleveland Medical Center. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic
NCT00921986
Recruiting
Biorepository of blood and or tissue samples from patients presenting with cardiac arrhythmia syndromes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/28/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Arrhythmias, Cardiac
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Distal Radius Interventions for Fracture Treatment
NCT05131685
Recruiting
This protocol describes a multicenter, prospective randomized superiority trial comparing functional outcomes between children treated with sedated reduction versus no formal reduction.
Gender:
ALL
Ages:
Between 4 years and 10 years
Trial Updated:
08/27/2024
Locations: University Hospitals Rainbow Babies & Children, Cleveland, Ohio
Conditions: Fracture Distal Radius
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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
NCT04613921
Recruiting
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-thre... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/27/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
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A Prospective Imaging Study of the Integrated TrueBeam-HyperSight CBCT System
NCT05975619
Recruiting
Cone beam computed tomography (CBCT) images are routinely used in radiation treatment delivery workflows to align patients with the treatment beam. Conventional CBCT image quality is sufficient for this task but not good enough for other radiotherapy-related tasks, such as contouring anatomical structures and calculating radiation dose distributions. HyperSight is a new CBCT imaging system manufactured by Varian Medical Systems. The purpose of this study is to evaluate the integration of the Hyp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/27/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Head and Neck Cancer, Thoracic Cancer, Abdominal Cancer, Pelvic Cancer
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tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia
NCT05866003
Recruiting
After a stroke, it is very common to lose the ability to open the affected hand. Occupational and physical rehabilitation therapy (OT and PT) combined with non-invasive brain stimulation may help a person recover hand movement. The purpose of this study is to compare 3 non-invasive brain stimulation protocols combined with therapy to see if they result in different amounts of recovery of hand movement after a stroke.
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
08/26/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Stroke, Upper Extremity Paresis, Hemiplegia
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Treatment for Migraine and Mood
NCT05576467
Recruiting
The researchers propose a three-arm pilot study of Mindfulness-Based Cognitive Therapy (MBCT) delivered via telephone (MBCT-T), video (MBCT-V) or Enhanced Usual Care (EUC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: The Cleveland Clinic, Cleveland, Ohio
Conditions: Migraine, Depressive Symptoms
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The Impact of Abdominal Wall Reconstruction on Abdominal Wall Tension and Intra-Abdominal Pressure
NCT06575166
Recruiting
This is a prospective cohort study. Patients have an incisional or parastomal hernia with \>20 cm fascial defect on pre-operative imaging who will undergo an anticipated open bilateral transversus abdominis release with retromuscular synthetic mesh will have their abdominal wall tension measured using a tension scale and their intra-abdominal pressure measured using a urinary catheter containing pressure sensors. The investigators aim to quantify the changes, as well as explore and describe the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/25/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Ventral Hernia, Incisional Hernia, Parastomal Hernia
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Fenofibrate for Prevention of DR Worsening
NCT04661358
Recruiting
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME at baseline. In addition to evaluating efficacy, this study aims to evaluate the feasibility of a model for ophthalmologists to prescribe or collaborate with a primary care provider such as an internist/endocrinologist to prescribe and monitor the dru... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/23/2024
Locations: The Cleveland Clinic Foundation DBA Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio
Conditions: Diabetic Retinopathy
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Grasp-Release Assessment of a Networked Neuroprosthesis Device
NCT05863754
Recruiting
The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/23/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio
Conditions: Spinal Cord Injury at C5-C7 Level, Spinal Cord Injuries, Spinal Cord Injury Cervical
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
NCT05855200
Recruiting
The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: GSK Investigational Site, Cleveland, Ohio +2 locations
Conditions: Colonic Neoplasms, Neoplasms, Colon
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The GUARDIAN Trial
NCT04884802
Recruiting
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management (routine pressure management).
Gender:
ALL
Ages:
45 years and above
Trial Updated:
08/23/2024
Locations: MetroHealth Medical Center, Cleveland, Ohio +2 locations
Conditions: Blood Pressure
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