Ohio is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction
NCT06883396
Recruiting
The goal of this observational study is to learn about the outcomes of medial patellofemoral ligament (MPFL) reconstruction for the treatment of recurrent patellar instability. The main questions it aims to answer are: * What are the risk factors for recurrent patellar instability after MPFL reconstruction? * What functional outcomes do patients report after MPFL reconstruction? Participants undergoing MPFL reconstruction will answer survey questions about their knee and activity level 1 year... Read More
Gender:
ALL
Ages:
Between 10 years and 35 years
Trial Updated:
03/12/2025
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Patellar Dislocation, Recurrent, Patellar Dislocation, Patellar Instability, Patellofemoral Dislocation, Patellofemoral Joint Dislocation, Patellofemoral Disorder
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Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
NCT06687603
Recruiting
The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test. Barrett's esophagus is a condition in which the flat pink lining of the swallowing tube that connects the mouth to the stomach (the esophagus) becomes damaged by acid reflux. The main question it aims to answer is: Can this approach demonstrate efficacy for screening of Barrett's esophagus? Participants will: * Participate in a questionnaire. * Undergo a... Read More
Gender:
ALL
Ages:
50 years and above
Trial Updated:
03/12/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
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Vulvovaginal Graft-versus-Host Disease: Diagnosis and Microbiome Evaluation
NCT06649201
Recruiting
The goal of this observational study is to investigate the development of vulvovaginal graft-versus-host- disease (GVHD), an under-reported and under-recognized manifestation of chronic GVHD. This study aims to characterize the vaginal microbiome in participants undergoing allogeneic hematopoietic cell transplantation (HCT). The main questions it aims to answer are: * Is the vaginal microbiome altered during allogeneic HCT? * What changes may help researchers understand the development of vulvo... Read More
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
03/12/2025
Locations: Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Graft Vs Host Disease, Vulvovaginal Signs and Symptoms
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Precise and Objective Identification of Bertolotti Syndrome Using Novel Kinematic Biomarkers
NCT06225583
Recruiting
The purpose of this study is to collect lumbar rotations, velocity, and accelerations, along with pain scores using a novel dynamic VAS device, from twenty (20) Bertolotti Syndrome patients and twenty (20) non-Bertolotti low back pain patients during range-of-motion tasks. The assessments will be analyzed to determine the differences in kinematics and continuous pain scores between Bertolotti patients and non-Bertolotti low back pain patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Bertolotti's Syndrome, Lower Back Pain
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A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
NCT06100289
Recruiting
The main aim of this study is to learn how the body of a child or teenager with moderately to severely active ulcerative colitis (UC) or Crohn's disease (CD) processes vedolizumab (pharmacokinetics) given just under the skin subcutaneously (SC). The participants will be treated with vedolizumab for up to 34 weeks. During the study, participants will visit their study clinic several times.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
03/12/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Ulcerative Colitis, Crohn's Disease
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Safety and Efficacy of NMD670 in Ambulatory Adult Patients With Type 3 Spinal Muscular Atrophy
NCT05794139
Recruiting
The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of NMD670 in the treatment of ambulatory adults with spinal muscular atrophy type 3
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/12/2025
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Spinal Muscular Atrophy
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Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
NCT03851445
Recruiting
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Aultman Alliance Community Hospital, Alliance, Ohio
Conditions: Previously Treated Non-Small Cell Lung Cancer
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Ethanol Induces Skeletal Muscle Autophagy
NCT03209791
Recruiting
In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/12/2025
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Alcoholic Liver Disease
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Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting
NCT03121404
Recruiting
Cirrhosis is characterized by loss of muscle as well as fat mass, which increases morbidity and mortality before, during, and after liver transplantation. A common mechanism for the reduced muscle and fat mass in cirrhosis is an increased expression of the TGF (transforming growth factor)beta superfamily member, myostatin, in the muscle and adipose tissue. The present study will examine the expression of myostatin, its receptor and intracellular signaling pathways in the skeletal muscle and mese... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/12/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Cirrhosis
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Comparing Two Surgical Techniques for Building Up the Bone Where a Dental Implant is to Be Placed
NCT06871657
Recruiting
The goal of this observational study is to compare two techniques routinely used to increase bone volume in the jaw prior to placing a dental implant, called osseocondensation and osseodensification. The study participants are healthy adults who are planning to get a dental implant. The main questions it aims to answer are: * Is there a difference in wound closure and soft tissue healing following implant placement using osseocondensation versus osseodensification? * Is there a difference in bo... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/11/2025
Locations: The Ohio State University College of Dentistry, Columbus, Ohio
Conditions: Dental Implant, Sinus Floor Augmentation
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Quantra Point-of-Care Hemostasis Monitoring
NCT06328647
Recruiting
The investigators will test the hypothesis that utilization of a blood and blood component transfusion algorithm guided by the POC Quantra QPlus System in patients undergoing complex cardiac surgery will reduce RBC, plasma, cryoprecipitate, and platelet transfusion during surgery and the first 12 postoperative hours, compared to standard of care (central laboratory transfusion monitoring at the primary anesthesia provider's discretion).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Bleeding, Hemostatic Disorder
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A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer
NCT06315491
Recruiting
The purpose of this study is to assess the safety, tolerability, and efficacy of CBX-12 in female subjects with platinum resistant or refractory ovarian cancer at 2 doses; 125 mg/m2 every 21 days or 100 mg/m2 every 21 days.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: University Hospitals Seidman Cancer Center, Cleveland, Ohio
Conditions: Platinum-resistant Ovarian Cancer, Refractory Ovarian Carcinoma
Register for Updates