Ohio is currently home to 3225 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19
NCT04858412
Recruiting
Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD) are at risk for severe illness and abrupt or sudden clinical deterioration with ventilatory failure. â-hydroxy â-methyl butyrate (HMB), a non-nitrogenous leucine metabolite with anabolic properties, increases muscle mass and contractile function and enhances immune function. We aim to study the natural course of COVID-19 in patients with ALD and test whether HMB can affect ventilatory deterioration and impr... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/08/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Alcoholic Liver Disease, COVID 19 Pneumonia
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rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease
NCT04833907
Recruiting
Canavan Disease is a congenital white matter disorder caused by mutations to the gene encoding for aspartoacylase (ASPA). Expression of ASPA is restricted to oligodendrocytes, the sole white matter producing lineage in the brain. ASPA supports myelination in the capacity of its sole known function, namely, the catabolism of N-acetylaspartate (NAA). Inherited mutations that result in loss of ASPA catabolic activity result in a typically severe phenotype of Canavan Disease, characterized by chroni... Read More
Gender:
ALL
Ages:
Between 3 months and 60 months
Trial Updated:
01/08/2025
Locations: Dayton Children's Hospital, Dayton, Ohio
Conditions: Canavan Disease
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Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy
NCT04096014
Recruiting
Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy and occurs because of impaired hepatic ureagenesis and increased skeletal muscle proteolysis. We propose a randomized, 6-month nutritional intervention in cirrhotic patients who have had at least 1 admission for hepatic encephalopathy within the last 6 months. We hypothesize that a combination of late evening and early morning protein supp... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/08/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Hepatic Encephalopathy
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Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
NCT04088370
Recruiting
Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of alcoholic liver disease. In addition to the inflammatory response mitochondrial perturbations exist and redox homeostasis is altered in patients with alcoholic hepatitis. Though this is known there have been very few studies targeting mitochondrial function in Peripheral Blo... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
01/08/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Alcoholic Hepatitis
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Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis
NCT03225677
Recruiting
To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Cirrhosis
Register for Updates
Comparison of ALD, NASH, and Healthy Control Patients
NCT03224949
Recruiting
The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate heavy drinking, yet healthy controls and non-drinking healthy controls, is an essential first step in the translation of basic research advances to the clinic. The purpose of the Clinical Core component of the P50 Northern Ohio Alcohol Center (NOAC) is to provide biological samples (plasma/serum, buffy coats, and urine) from patients with different stages of alcoholic l... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/08/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: ALD - Alcoholic Liver Disease
Register for Updates
Measuring Outcomes of LASIK and EVO-ICL in Matched Populations
NCT06700460
Recruiting
Evaluating outcomes after bilateral implantation of ICLs or bilateral LASIK as treatment options for the correction or reduction of myopia with or without astigmatism.
Gender:
ALL
Ages:
Between 21 years and 45 years
Trial Updated:
01/07/2025
Locations: Cleveland Eye Clinic, Cleveland, Ohio
Conditions: Myopia
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Milk Thistle Clinical Trial in Pediatric NAFLD
NCT06477146
Recruiting
Pediatric Fatty Liver disease is a growing problem in the United States and is expected to be the leading cause of Liver Transplantation in Adults in 20 years. Following lifestyle changes such as diet restrictions and exercise may be difficult to consistently maintain. The purpose of this study is to investigate alternative medical therapy with an herbal supplement called Milk Thistle (MT) which may improve fatty liver disease and would be easier to follow than diet and exercise.
Gender:
ALL
Ages:
Between 9 years and 22 years
Trial Updated:
01/07/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Non-Alcoholic Fatty Liver Disease (NAFLD)
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Effect of C-peptide on Hypoglycemic Counterregulation
NCT06470295
Recruiting
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes. We have observed that the naturally occurring protein C-peptide increases glucagon secretion in dogs during insulin-induced hy... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
01/07/2025
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Hypoglycemia, Type 1 Diabetes
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HIT-Stroke Trial 2
NCT06268041
Recruiting
People who had a stroke at least 6 months prior and who still have difficulty with walking will each be randomly assigned to receive either moderate or vigorous intensity walking exercise. Both protocols will be performed individually with a physical therapist for 45 minutes, 3x/week for 12 weeks. Measures including walking function will be assessed at baseline (PRE), after 4, 8 and 12 weeks of training (12WK) and at 3-month follow up (3moPOST), by raters who are unaware of the participant rando... Read More
Gender:
ALL
Ages:
Between 30 years and 85 years
Trial Updated:
01/07/2025
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Stroke
Register for Updates
Comparing Reduction With ESD- Versus APC-TORe
NCT06131281
Recruiting
The goal of this clinical trial is to compare two variations of the same procedure used to assist with weight loss in patients who have a history of Roux-en-Y gastric bypass who have experienced weight regain. The procedure being studied is called the Transoral Outlet Reduction (TORe), and the trial will compare two different ways to complete the TORe procedure. The main question\[s\] it aims to answer are: * Which variation of the TORe procedure results in more weight loss? * Which variation o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Obesity, Roux-en-y Anastomosis Site, Weight Gain
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OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers
NCT05799105
Recruiting
The goal of this clinical trial is to identify the most effective way to take acid-blocking medications to treat stomach ulcers in patients who have undergone gastric bypass surgery. The main questions it aims to answer are: * is taking an acid-blocking medication by opening the capsule and only taking the contents of the capsule (open-capsule) more or less effective than taking the capsule as a whole (intact-capsule) for treating ulcers in patients who have a history of gastric bypass surgery?... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/07/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Marginal Ulcer
Register for Updates