Ohio is currently home to 3201 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC
NCT05682443
Recruiting
In this Phase 2 study, mCRPC patients with PSMA positive scans who progressed on prior ARTA and up to 2 lines of taxanes, and are naïve to lutetium Lu 177 vipivotide tetraxetan, will be enrolled. The study is open-label, randomized with active control, multi-center study.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: The Ohio State University James Cancer Center - 1636, Columbus, Ohio
Conditions: Metastatic Castration-resistant Prostate Cancer
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Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML
NCT05503134
Recruiting
This is a phase I/II dose escalation study designed to determine the safety and estimate the efficacy of UD-NK cells combined with FLA chemotherapy in patients age 1-24.99 with relapsed or refractory acute myeloid leukemia. PRIMARY OBJECTIVE: I. To determine the safety and recommended phase II dose of adoptive NK cell therapy using UD-NK cells in pediatric and young adult patients with relapsed/refractory AML. SECONDARY OBJECTIVES: I. To estimate the efficacy of UD- NK cells with FLA chemoth... Read More
Gender:
ALL
Ages:
Between 1 year and 24 years
Trial Updated:
11/01/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Acute Myeloid Leukemia
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A Gene Hunting Study for Familial Papillary Thyroid Cancer
NCT02776969
Recruiting
The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Thyroid
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Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
NCT06670040
Recruiting
Evaluate the efficacy of accelerated theta burst stimulation (aTBS) in reducing depressive symptoms in autism spectrum disorder (ASD)
Gender:
ALL
Ages:
Between 13 years and 26 years
Trial Updated:
10/31/2024
Locations: Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio
Conditions: ASD, Autism Spectrum Disorder, Autism, Depression - Major Depressive Disorder, MDD
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Developing Inclusive Support and Intervention for Spanish-speaking Latiné Prostate Cancer Survivors
NCT06435871
Recruiting
Prostate cancer is a significant concern for Latiné men, with over 17,000 new cases annually. Decision-making for treatment is complex, especially due to barriers like low health literacy and cultural factors. Research on survivorship and post-treatment issues like erectile dysfunction is lacking. To improve care, a study will engage 288 participants across various medical facilities, including 100 at Cleveland Clinic. Thirty subjects will participate in focus groups representing Spanish-speakin... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Cleveland Clinic Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Prostate Cancer
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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
NCT06399705
Recruiting
This is a research study in minorities to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival an... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Ohio State University, Columbus, Ohio
Conditions: Coronary Artery Disease
Register for Updates
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
NCT06399692
Recruiting
This is a research study in women to compare the outcomes of two procedures that restore blood flow to the arteries of the heart. In one procedure the blockages are ballooned and then stented with a small wire mesh tube through a small incision in the wrist or the groin. The other procedure is an open-heart operation in which healthy blood vessels from inside the chest, leg, and/or forearm are used to "bypass" the blockages (like a detour). Outcomes will be measured by comparing survival and imp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2024
Locations: Ohio State University, Columbus, Ohio
Conditions: Coronary Artery Disease
Register for Updates
Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
NCT06311708
Recruiting
This is a multicenter, non-interventional study to observe the natural progression of the disease and to study the prevalence of pre-existing antibodies to AAV9 used for gene therapy in a population of patients with PKP2 gene-associated ARVC. Participation from all patients is encouraged regardless of interest in or eligibility for gene therapy.
Gender:
ALL
Ages:
Between 14 years and 65 years
Trial Updated:
10/30/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy
Register for Updates
Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or Social Anxiety Disorders.
NCT04221997
Recruiting
A Multicenter, acute, randomized, double-blind, placebo-controlled, flexible-dose trial with the treatment of sertraline.
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
10/30/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Anxiety Disorders
Register for Updates
Study to Evaluate of EXG34217 in Patients With Telomere Biology Disorders With Bone Marrow Failure
NCT04211714
Recruiting
This is a Phase I/II, open label, single center study to assess the safety and tolerability of EXG34217 in bone marrow failure patients with telomere biology disorders.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/30/2024
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Telomere Shortening, Bone Marrow Failure
Register for Updates
Food for Thought - a Nutrition Intervention for Women Undergoing Active Treatment for Triple Negative Breast Cancer
NCT06582615
Recruiting
The goal of this randomized clinical trial is to learn if a healthy eating pattern called the MIND eating plan can reduce cancer-related cognitive impairment (commonly called "chemobrain") and other symptoms commonly experienced by women with newly diagnosed stage II-III triple negative breast cancer as they go through chemotherapy. The symptoms that will be measured include changes in memory and mental function, fatigue, sleep quality, anxiety, and depression. Researchers will compare measures... Read More
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
10/29/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Triple-Negative Breast Carcinoma
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68Ga-DOTATATE PET/CT for the Diagnosis of Soft Tissue Sarcomas
NCT06500065
Recruiting
This trial studies how well 68Ga-DOTATATE digital PET/CT work in diagnosing soft tissue sarcoma. 68Ga-DOTATATE is a radiotracer that may improve image quality of PET imaging. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 68Ga-DOTATATE. CT images provide an exact outline of organs and potential inflammatory tissue where it occurs in patient's body. 68Ga-DOTATATE digital PET/CT may work... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Soft Tissue Sarcoma
Register for Updates