Ohio is currently home to 3204 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)
NCT06322693
Recruiting
This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as monotherapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: GSK Investigational Site, Cincinnati, Ohio
Conditions: Neoplasms
Register for Updates
Evaluation of the PrevisEA Device for Predicting Gastrointestinal Impairment
NCT04880473
Recruiting
PrevisEA is a noninvasive, disposable device that uses audio spectral analysis of sounds produced by the gastrointestinal tract to predict gastrointestinal impairment (GII). GII is most commonly associated with postoperative ileus (POI), but could be the result of other causes, such as early postoperative bowel obstruction. GII is defined as failure of successful early oral re-feeding in a subject undergoing major abdominal surgery. For subjects who are allowed to resume a diet during the first... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/11/2024
Locations: The Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Gastrointestinal Complication
Register for Updates
Prospective SPINE Registry
NCT04176562
Recruiting
This study is a prospective, multi-center, open label registry designed to collect real-world data on performance and safety data on RTI's spine products.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: Lindner Center for Research & Education at The Christ Hospit, Cincinnati, Ohio
Conditions: Sacroiliac; Fusion, Sacroiliac, Joint Diseases, Musculoskeletal Diseases, Spinal Disease, Spinal Stenosis, Spinal Instability, Fusion of Joint, Fusion of Spine, Spinal Fusion, Spine
Register for Updates
RChildUV:Study on Non-infectious Chronic Uveitis in Pediatric Age
NCT06273748
Recruiting
Uveitis is an inflammatory disease of the uvea, one of the highly vascularized fundamental structures of the eye. It is a rare condition in children, with an incidence in the pediatric population ranging from 2% to 14% of all uveitis cases. The diagnosis and management of patients with uveitis rely on a multidisciplinary approach involving an ophthalmologist, a rheumatologist, and an infectious disease specialist to establish the correct diagnosis and assess the involvement of other organs. In I... Read More
Gender:
ALL
Ages:
Between 1 year and 16 years
Trial Updated:
03/07/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Uveitis
Register for Updates
Remote Monitoring and Detecting of Tardive Dyskinesia for Improving Patient Outcomes
NCT06011408
Recruiting
The study is being conducted to validate the feasibility of remote assessment of Tardive Dyskinesia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2024
Locations: Charak Research Center, Garfield Heights, Ohio
Conditions: Tardive Dyskinesia
Register for Updates
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Ulcerative Colitis, Crohn's Disease
Register for Updates
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
NCT05002543
Recruiting
MANTRA is a prospective, multiple-arm, multi-center, global, post-market clinical follow-up study. The main objective is to monitor ongoing safety and performance of the CORCYM devices and accessories used for aortic, mitral and tricuspid valvular diseases in a real-world setting. Corcym S.r.l., is a medical device manufacturer with a broad product portfolio for cardiac surgeons, offering solutions for the treatment of aortic, mitral and tricuspid valve disease. The MANTRA Master Plan (Master... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/05/2024
Locations: University Hospitals Cleveland, Cleveland, Ohio
Conditions: Cardiac Valve Disease
Register for Updates
High-resolution MRI of Atrial Fibrillation Patients Prior to Focal Impulse and Rotor Modulation (FIRM) Ablation
NCT03444337
Recruiting
Patients undergoing FIRM guided ablation of atrial fibrillation will undergo high resolution MRI imaging to determine correlation of underlying anatomic fibrotic regions with FIRM targeted sites for ablation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Ohio State University, Columbus, Ohio
Conditions: Atrial Fibrillation
Register for Updates
Kaneka Endovascular Embolization and Protection
NCT05563051
Recruiting
Prospective, multi-center, non-randomized registry / study, up to 164 patients enrolled and followed at 180 days +/- 45 days and again at 365 days +/- 90 days post procedure
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/04/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Aneurysm Cerebral
Register for Updates
Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
NCT01158807
Recruiting
This study is one of the three projects of an NIH Rare Disease Clinical Research Consortium. A "consortium" is a group of centres sharing information and resources to perform research. The consortium research focuses on brain blood vessel malformations in three different rare diseases. The focus of this specific study is on Hemorrhagic Telangiectasia (HHT). HHT is a condition characterized by blood vessel malformations, called telangiectasia and arteriovenous malformations (AVMs), occurring in... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/04/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Hereditary Hemorrhagic Telangiectasia
Register for Updates
A Pilot Study in Endoscopic Therapy on Quality of Life and Pain in Chronic Pancreatitis
NCT05012150
Recruiting
This study is a prospective study designed to assess the effect of pancreatic endotherapy on quality of life, pain levels, pancreatic exocrine function, and endocrine function.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/03/2024
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Chronic Pancreatitis
Register for Updates
Chemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY)
NCT03997981
Recruiting
This is a prospective natural history study of CIPN in approximately 200 participants receiving taxanes (paclitaxel, docetaxel) for breast cancer, bortezomib for multiple myeloma, oxaliplatin-based regimens for colorectal cancer, or vincristine for lymphoma.. Demographic data, medical history, electronic PROs, ClinROs blood biomarkers including NF-L, PGx DNA analyses and Bedside-QST will be assessed at Baseline. The Observation Period will initiate with the first dose of chemotherapy and conclud... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Ohio State University, Columbus, Ohio
Conditions: Chemotherapy-induced Peripheral Neuropathy
Register for Updates