Ohio is currently home to 3328 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke
NCT05175547
Recruiting
The CLEVER Study is a prospective, 2-arm, randomized, single-center pilot study to assess the safety and efficacy of intensive blood pressure control using Clevidipine (on-label use) in AIS patients undergoing standard of care mechanical thrombectomy (MT) within 24-hours of symptoms onset.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: ProMeedica Toledo Hospital, Toledo, Ohio
Conditions: Stroke, Acute, Blood Pressure, Mechanical Thrombectomy
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A Study of DF6002 Alone and in Combination With Nivolumab
NCT04423029
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug-levels, drug-effects and preliminary anti-tumor activity of DF6002 alone and in combination with Nivolumab in participants with advanced solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/19/2023
Locations: Local Institution, Cleveland, Ohio
Conditions: Solid Tumors
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Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. Until recently, the mainstay of treatment for these patients was supportive medical care. Howe... Read More
Gender:
All
Ages:
All
Trial Updated:
04/18/2023
Locations: Akron Children's Hospital, Akron, Ohio
Conditions: Spinal Muscular Atrophy (SMA)
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Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
NCT05355974
Recruiting
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events. The hypothesis is that use of vasopressors during Rapid Sequence Intubation will prevent substantial decreases in blood pressure when compared to normal intravenous fluids.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/17/2023
Locations: Miami Valley Hospital Premier Health, Dayton, Ohio
Conditions: Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication, Anesthesia Intubation Complication
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RHYTHMIA vs CARTO in Redo Ablation Procedures for Atrial Fibrillation
NCT04835844
Recruiting
The MAP-AF study will compare RHYTHMIA vs CARTO in redo ablation of paroxysmal AF with assessment of both acute procedural profiles and clinical outcomes.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
04/17/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Paroxysmal Atrial Fibrillation
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Sleep Timing, Eating and Activity Measurement Study
NCT04992611
Recruiting
There is strong reason to believe that sleep promotion during adolescence could yield long-term health rewards; the investigators' data show that, when they get more sleep, Morning Larks have impressively reduced intake of overall calories and foods high in glycemic load that are linked to long-term health risk. Before that can be translated into major public health interventions, however, the field needs to understand why similar changes in sleep had no effect, or even an adverse effect, on ado... Read More
Gender:
All
Ages:
Between 14 years and 18 years
Trial Updated:
04/13/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Sleep, Circadian Rhythm Disorders, Dietary Habits
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Comparison of Methods of Pulmonary Blood Flow Augmentation in Neonates: Shunt Versus Stent (The COMPASS Trial)
NCT05268094
Recruiting
COMPASS is a prospective multicenter randomized interventional trial. Participants with ductal-dependent pulmonary blood flow will be randomized to receive either a systemic-to-pulmonary artery shunt or ductal artery stent. Block randomization will be performed by center and by single vs. two ventricle status. Participants will be followed through the first year of life.
Gender:
All
Ages:
Between 1 day and 30 days
Trial Updated:
04/12/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Congenital Heart Disease in Children
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Hairy Cell Leukemia Patient Data Registry
NCT02560883
Recruiting
The overall objective is to develop a clinical data registry that can be used to facilitate research with the ultimate goal of reducing the morbidity and/or mortality and improving the quality of life of patients diagnosed or living with hairy cell leukemia. With approximately 1,000 new cases of this rare disease identified in the US each year, HCL represents 2% of all cases of leukemia in adults. Considering the rarity of this chronic leukemia, the Hairy Cell Leukemia Foundation (HCLF), in part... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2023
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Leukemia, Other
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Safety and Effectiveness of the HIT Reverse HRS
NCT05357378
Recruiting
The purpose of this study is to determine if the use of the HIT Reverse Hip Replacement System is safe and effective in patients undergoing total hip replacement. We will determine whether it is safe and effective by comparing it to the control devices.
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
04/11/2023
Locations: JIS Orthopedics, New Albany, Ohio
Conditions: Degenerative Joint Disease, Osteoarthritis, Hip, Avascular Necrosis of Hip, Traumatic Arthropathy-Hip
Register for Updates
International Consortium for Multimodality Phenotyping in Adults With Non-compaction
NCT04424030
Recruiting
Non-compaction cardiomyopathy (NCCM) is a heterogeneous, poorly understood disorder characterized by a prominent inner layer of loose myocardial tissue, and associated with heart failure, stroke, severe rhythm irregularities and death. For a growing population diagnosed with NCCM there is a need for better risk stratification to appropriately allocate (or safely withhold) these impactful preventive measures. The goal of this international consortium is to improve care of patients with non-compac... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2023
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Non-Compaction Cardiomyopathy
Register for Updates
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
NCT05706909
Recruiting
The purpose of this study is to assess the clinical and x-ray results of patients who are treated with core decompression of the hip and the injection of a bone marrow concentrate and the use of the Bone Graft Substitute Genex®.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/10/2023
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Avascular Necrosis, Osteonecrosis
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Screening for High Frequency Malignant Disease
NCT05117840
Recruiting
The SHIELD (Screening for High Frequency Malignant Disease) study is a prospective, observational, multi-site basket design trial without randomization. The primary objective of the study is to evaluate the sensitivity and specificity of a blood-based GuardantLUNAR-2 test to detect high frequency cancer in screen-relevant populations.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
04/10/2023
Locations: Gabrail Cancer Center, Canton, Ohio
Conditions: Lung Cancer
Register for Updates