Ohio is currently home to 3201 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation
NCT05902533
Recruiting
To determine the efficacy of reduced elective nodal radiation in anal cancer patients undergoing chemoradiation in reducing toxicity compared to standard nodal irradiation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2024
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Anal Cancer
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Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
NCT05049330
Recruiting
Cervical spine injuries (CSI) are serious, but rare events in children. Spinal precautions (rigid cervical collar and immobilization on a longboard) in the prehospital setting may be beneficial for children with CSI, but are poorly studied. In contrast, spinal precautions for pediatric trauma patients without CSI are common and may be associated with harm. Spinal precautions result in well-documented adverse physical and physiological sequelae. Of substantial concern is that the mere presence of... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/21/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Cervical Spine Injury
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Comparing Hypothermic Temperatures During Hemiarch Surgery
NCT02860364
Recruiting
Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to eith... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2024
Locations: Ohio State University Medical Center, Columbus, Ohio
Conditions: Thoracic Aortic Disease
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Transcutaneous Pulse Oximetry Brain Monitoring Study (US)
NCT06267131
Recruiting
This is a study of adult patients with a severe and sudden brain injury who have a drain placed in their brain to measure pressure. The purpose of the study is to monitor the pressure in the brain using a monitor placed on the forehead, and compare this to a drain placed in the brain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2024
Locations: Cleveland Clinic, Neurological Institute, Cleveland, Ohio
Conditions: Acute Brain Injury
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Mucosal Impedance Sleeve Gastrectomy
NCT04166461
Recruiting
Obesity is a growing epidemic and bariatric surgery has been shown to be the most effective and efficient mean of achieving significant and sustainable weight loss in morbidly obese individuals. Studies have demonstrated that after LSG, between 5 and 30% of patients suffered from GERD, with a small subset of those patients (2.9 %) converting to another bariatric procedure (gastric bypass) because of debilitating GERD symptoms. The investigators propose this current study to examine mucosal impe... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/16/2024
Locations: MetroHealth - Main Campus Medical Center, Cleveland, Ohio
Conditions: Gastroesophageal Reflux, Bariatric Surgery Candidate
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Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings
NCT06093490
Recruiting
This study is being done to find out if a smartphone app can identify absence seizures. Children who have a history of absence seizures, as well as children without any seizure history, will be testing out the app. If participating the child will be guided through hyperventilation, an activity that asks the child to take quick, deep breaths. The app will record video of the child's face and sounds they make during hyperventilation. Hyperventilation is a safe and established technique frequently... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
02/15/2024
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Absence Epilepsy, Childhood, Absence Seizures, Absence Epilepsy, Epilepsy in Children, Staring, Seizures
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ELUCIDATE FFRct Study
NCT06018194
Recruiting
The goal of this study is to evaluate the diagnostic accuracy of a novel plaque-based coronary CT angiography (CCTA) fractional flow reserve (FFRct) software device for the estimation of invasive fractional flow reserve (FFR). Researchers will compare the Elucid plaque-based FFRct analysis to invasively measured FFR in patients who have previously undergone CCTA and invasively assessed FFR.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Coronary Artery Disease
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cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881
Recruiting
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mort... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/15/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer, Colorectal Cancer, Endometrial Cancer, Esophageal Cancer, Stomach Cancer, Head and Neck Cancer, Hepatobiliary Cancer, Leukemia, Lung Cancer, Lymphoma, Multiple Myeloma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Renal Cancer, Sarcoma, Thyroid Cancer
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Speed Manipulated Adaptive Rehabilitation Therapy Bike for Parkinson's Disease
NCT05361200
Recruiting
Parkinson's disease (PD) is a progressive neurological disorder that results in slowness of movement, muscle stiffness, tremor, and postural instability. These symptoms significantly affect PD patients' quality of life, independence, and functional performance. There is currently no cure for PD, but symptoms can be treated with levodopa or deep brain stimulation surgery. Exercise-based rehabilitation has similar beneficial effects to surgical and pharmacological management without the potential... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
02/14/2024
Locations: Kent State University, Kent, Ohio
Conditions: Parkinson Disease
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A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH
NCT04764474
Recruiting
An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in subjects with advanced relapsed, refractory, or resistant hematological malignancies that harbor IDH mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: The Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Isocitrate Dehydrogenase Gene Mutation
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The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
NCT04329728
Recruiting
This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid malignancies.
Gender:
ALL
Ages:
Between 12 years and 95 years
Trial Updated:
02/13/2024
Locations: Gabrail Cancer Center Research,, Canton, Ohio
Conditions: Lymphoid Malignancies
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Case Western Medical College, Cleveland, Ohio
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
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