Ohio is currently home to 3231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
rTMS Plus CCFES-mediated Functional Task Practice for Severe Stroke
NCT03870672
Recruiting
This study is a necessary and important step in the development of a new therapy for upper limb functional recovery in patients with severe motor impairment. It is the first clinical trial of non-invasive brain stimulation (repetitive transcranial magnetic stimulation or rTMS) delivered to excite the undamaged hemisphere (specifically the contralesional higher motor cortices or cHMC) in stroke. Therefore, this study will determine whether the positive results obtained in our short-term pilot stu... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
02/22/2024
Locations: Lerner Research Institute; Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Stroke, Hemiplegia, Cerebrovascular Accident (CVA), Hemiparesis
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Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery
NCT03319082
Recruiting
The objectives of this post market registry are to evaluate the safety and durability of treatment effect up to 3 years following cross-linking performed with Photrexa Viscous (riboflavin 5'- phosphate in 20% dextran ophthalmic solution), Photrexa (riboflavin 5'- phosphate ophthalmic solution), and the KXL System in patients with corneal ectasia following refractive surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Comprehensive EyeCare of Central Ohio, Westerville, Ohio
Conditions: Corneal Ectasia
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REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation
NCT05902533
Recruiting
To determine the efficacy of reduced elective nodal radiation in anal cancer patients undergoing chemoradiation in reducing toxicity compared to standard nodal irradiation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2024
Locations: University of Cincinnati Medical Center, Cincinnati, Ohio
Conditions: Anal Cancer
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Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
NCT05049330
Recruiting
Cervical spine injuries (CSI) are serious, but rare events in children. Spinal precautions (rigid cervical collar and immobilization on a longboard) in the prehospital setting may be beneficial for children with CSI, but are poorly studied. In contrast, spinal precautions for pediatric trauma patients without CSI are common and may be associated with harm. Spinal precautions result in well-documented adverse physical and physiological sequelae. Of substantial concern is that the mere presence of... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/21/2024
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Cervical Spine Injury
Register for Updates
Comparing Hypothermic Temperatures During Hemiarch Surgery
NCT02860364
Recruiting
Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to eith... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2024
Locations: Ohio State University Medical Center, Columbus, Ohio
Conditions: Thoracic Aortic Disease
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Heat Loss in Humans Covered With Full-Body Blankets Connected to Different Warming Devices
NCT06198959
Recruiting
The investigators propose a single-center multiple crossover randomized trial to determine the efficacy of four warming devices and five warming blankets. The investigators will measure cutaneous heat loss/ gain using thermal flux transducers in unanesthetized volunteers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Heat Transfer by Clinical Warming Devices
Register for Updates
Transcutaneous Pulse Oximetry Brain Monitoring Study (US)
NCT06267131
Recruiting
This is a study of adult patients with a severe and sudden brain injury who have a drain placed in their brain to measure pressure. The purpose of the study is to monitor the pressure in the brain using a monitor placed on the forehead, and compare this to a drain placed in the brain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/18/2024
Locations: Cleveland Clinic, Neurological Institute, Cleveland, Ohio
Conditions: Acute Brain Injury
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Mucosal Impedance Sleeve Gastrectomy
NCT04166461
Recruiting
Obesity is a growing epidemic and bariatric surgery has been shown to be the most effective and efficient mean of achieving significant and sustainable weight loss in morbidly obese individuals. Studies have demonstrated that after LSG, between 5 and 30% of patients suffered from GERD, with a small subset of those patients (2.9 %) converting to another bariatric procedure (gastric bypass) because of debilitating GERD symptoms. The investigators propose this current study to examine mucosal impe... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/16/2024
Locations: MetroHealth - Main Campus Medical Center, Cleveland, Ohio
Conditions: Gastroesophageal Reflux, Bariatric Surgery Candidate
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Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings
NCT06093490
Recruiting
This study is being done to find out if a smartphone app can identify absence seizures. Children who have a history of absence seizures, as well as children without any seizure history, will be testing out the app. If participating the child will be guided through hyperventilation, an activity that asks the child to take quick, deep breaths. The app will record video of the child's face and sounds they make during hyperventilation. Hyperventilation is a safe and established technique frequently... Read More
Gender:
ALL
Ages:
Between 4 years and 12 years
Trial Updated:
02/15/2024
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Absence Epilepsy, Childhood, Absence Seizures, Absence Epilepsy, Epilepsy in Children, Staring, Seizures
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ELUCIDATE FFRct Study
NCT06018194
Recruiting
The goal of this study is to evaluate the diagnostic accuracy of a novel plaque-based coronary CT angiography (CCTA) fractional flow reserve (FFRct) software device for the estimation of invasive fractional flow reserve (FFR). Researchers will compare the Elucid plaque-based FFRct analysis to invasively measured FFR in patients who have previously undergone CCTA and invasively assessed FFR.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Coronary Artery Disease
Register for Updates
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
NCT05366881
Recruiting
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mort... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
02/15/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer, Colorectal Cancer, Endometrial Cancer, Esophageal Cancer, Stomach Cancer, Head and Neck Cancer, Hepatobiliary Cancer, Leukemia, Lung Cancer, Lymphoma, Multiple Myeloma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer, Renal Cancer, Sarcoma, Thyroid Cancer
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Speed Manipulated Adaptive Rehabilitation Therapy Bike for Parkinson's Disease
NCT05361200
Recruiting
Parkinson's disease (PD) is a progressive neurological disorder that results in slowness of movement, muscle stiffness, tremor, and postural instability. These symptoms significantly affect PD patients' quality of life, independence, and functional performance. There is currently no cure for PD, but symptoms can be treated with levodopa or deep brain stimulation surgery. Exercise-based rehabilitation has similar beneficial effects to surgical and pharmacological management without the potential... Read More
Gender:
ALL
Ages:
Between 50 years and 79 years
Trial Updated:
02/14/2024
Locations: Kent State University, Kent, Ohio
Conditions: Parkinson Disease
Register for Updates