Ohio is currently home to 3231 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Cincinnati, Columbus, Cleveland and Dayton. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma
NCT04942067
Recruiting
This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy, and PK/ Pharmacodynamics of APG-2575 in combination with Pd/DRd in patients with relapsed/refractory (RR) multiple myeloma (MM). The study consists of dose escalation and dose expansion phases. The study consists of will start with 2 arms noted below, both arms are independent
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Cleveland Clinic Hosptials, Cleveland, Ohio
Conditions: Multiple Myeloma, Amyloidosis
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Magnetic Resonance Elastography in Patients With Abdominal Aortic Aneurysms
NCT02387255
Recruiting
The main objective of this study is to utilize Magnetic Resonance Elastography (MRE) to determine tissue stiffness of abdominal aortic aneurysms (AAA). For patients with AAA, MRE is a more sensitive and superior method of determining the risk for rupture of AAA based on stiffness estimates when compared to the current, crude method of assessing risk based on measurement of the diameter of the aneurysm. The investigators will also validate the stiffness estimates against gold standard i.e. mechan... Read More
Gender:
ALL
Ages:
20 years and above
Trial Updated:
10/23/2023
Locations: The Ohio State University Medical Center, Columbus, Ohio
Conditions: Abdominal Aortic Aneurysm
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Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
NCT01757730
Recruiting
Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Heart Failure, Liver Fibrosis, Cardiac Transplant Rejection, Aortic Aneurysms
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Cognitive Status After Removal of Skull Base Meningioma
NCT04635657
Recruiting
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/22/2023
Locations: Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Meningioma, Skull Base Meningioma, Frontal Meningioma, Temporal Meningioma, Cognitive Impairment, Cognitive Decline, Post-Surgical Cognition
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Long-Term Longitudinal QoL in Patients Undergoing EEA
NCT04087902
Recruiting
This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/22/2023
Locations: Ohio State University, Columbus, Ohio
Conditions: Pituitary Tumor, Meningioma, Rathke Cleft Cysts, Chordoma, Chondrosarcoma, Craniopharyngioma, Encephalocele, Esthesioneuroblastoma
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FSHD Molecular Characterization
NCT06096441
Recruiting
To characterize the clinical and molecular phenotype of FSHD.
Gender:
ALL
Ages:
13 years and above
Trial Updated:
10/20/2023
Locations: The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio
Conditions: Facio-Scapulo-Humeral Dystrophy
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A Study of HB0045 Injection in Patients With Advanced Solid Tumors
NCT06056323
Recruiting
This is a phase I/II, open-label, multicenter study . During the study, subjects will be evaluated for safety, toxicity, tolerability, PK/PD, immunogenicity, biomarkers, and antitumor activity of HB0045. The phase I study will enroll up to 54 subjects with advanced solid tumors who have progressed on or after standard of care therapy and for whom there is no further treatment available that in the judgement of the patient's physician would be beneficial. One cycle is defined as 21 days.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: The Gabrail Pharmacology Phase 1 Research Center LLC, Canton, Ohio
Conditions: Solid Tumor, Adult
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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for at least 14 days and no more than 60 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and imp... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/17/2023
Locations: OhioHealth Research Institute, Columbus, Ohio
Conditions: Iliofemoral; Thrombosis
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EASE: The Materna Prep Pivotal Study
NCT03973281
Recruiting
This study is designed to evaluate the safety and effectiveness of the Materna Prep Device in reducing pelvic muscle injuries during vaginal delivery. Subjects are randomized to Materna Prep Device or Standard of Care without use of the Materna Prep Device Intervention with the Materna Prep Device is expected to be a one-time use of approximately 30-90 minutes during the 1st stage of labor. Subject participation in the study is targeted to be 12 months from the time of the use of the device d... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: The Metro Health System, Cleveland, Ohio
Conditions: Vaginal Delivery, Pelvic Organ Prolapse
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PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.
NCT05306743
Recruiting
A 3-year cluster randomized controlled trial of the impact of a quality improvement and clinical decision support package versus usual care for patients with modifiable high-risk chronic obstructive pulmonary disease with or without a current diagnosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: MetroHealth, Cleveland, Ohio
Conditions: Chronic Obstructive Pulmonary Disease
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Identification of Novel Markers of Human Lung Disease
NCT02369575
Recruiting
The purpose of this study is to investigate new therapies for advanced lung disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: Davis Heart and Lung Research Institute, Columbus, Ohio
Conditions: Lung Diseases, Interstitial
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Desara ® One Single Incision Sling 522 Study
NCT04772131
Recruiting
A post-market study to compare the safety and effectiveness of the Desara® One Single Incision Sling (SIS), when compared to that of an FDA cleared transobturator sling over a period of 36 months.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/09/2023
Locations: The Lindner Research Center at The Christ Hospital, Cincinnati, Ohio
Conditions: Stress Urinary Incontinence
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