Oklahoma is currently home to 859 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Oklahoma City, Tulsa, Norman and Edmond. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Efficacy of Clopidogrel on Incidence of Silent Brain Infarction
NCT04698031
Recruiting
Silent brain infarctions (SBIs) are a manifestation of covert cerebrovascular disease, without obvious clinical deficit, noted very often in patients presenting with a new stroke or new transient ischemic attack. SBIs are linked to a significant increase in risk for subsequent stroke and cognitive decline. However, no biomarker is currently available that can predict the recurrence of these subclinical lesions. Coated-platelets are a measure of platelet procoagulant potential significantly incre... Read More
Gender:
ALL
Ages:
Between 21 years and 90 years
Trial Updated:
02/11/2025
Locations: Oklahoma City VA Medical Center, Oklahoma City, OK, Oklahoma City, Oklahoma
Conditions: Silent Brain Infarction
Register for Updates
Relugolix + Enzalutamide Study in High-Risk Prostate Cancer
NCT06130995
Recruiting
The goal of this clinical trial is to test how effective and safe it is to use a combination of two medications, relugolix and enzalutamide, in patients with advanced prostate cancer. We want to see if this combination can help improve the chances of curing the cancer and make the patients live longer without the cancer getting worse. The main questions we want to answer in this study are: * Can using relugolix and enzalutamide together help increase the chances of curing high-risk advanced pr... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: Stephenson Cancer Center at OU Health, University of Oklahoma Health Sciences Center (SCC-OUHSC), Oklahoma City, Oklahoma
Conditions: Androgen Deprivation Therapy, Locally Advanced Prostate Cancer
Register for Updates
Identify microRNAs in Cachexia in Pancreatic Carcinoma
NCT05275075
Recruiting
The purpose of this study is to determine the proportion of pancreatic patients who experience weight loss and cachexia, and to identify any differences in the genes between patient groups.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/07/2025
Locations: Stephenson Cancer Center, Oklahoma City, Oklahoma
Conditions: Resectable Pancreatic Adenocarcinoma
Register for Updates
Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children
NCT05026749
Recruiting
The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway.
Gender:
ALL
Ages:
Between 3 days and 2 years
Trial Updated:
02/07/2025
Locations: Oklahoma Health Sciences, Oklahoma City, Oklahoma
Conditions: Respiratory Syncytial Virus Infections
Register for Updates
Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S01)
NCT06498661
Recruiting
This clinical trial evaluates the use of self-collected vaginal samples for human papillomavirus (HPV) testing in patients referred for a colposcopy and/or cervical excisional procedures to improve cervical cancer prevention. HPV is a common virus which usually causes infections that last only a few months, but sometimes can last longer. It is known to cause a variety of cancers including cancer of the cervix. Even though there are ways to detect cervical cancer early, many individuals do not un... Read More
Gender:
FEMALE
Ages:
25 years and above
Trial Updated:
02/06/2025
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Conditions: Cervical Carcinoma, Human Papillomavirus Infection
Register for Updates
A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib
NCT05512208
Recruiting
The purpose of this research is to test the effectiveness and safety of the study drugs (VS-6766 and defactinib), and see what effects (good and bad) these drugs have on the patients with endometrioid cancer, mucinous ovarian cancer, high-grade serous ovarian cancer, or solid gynecological cancer.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
02/06/2025
Locations: Stephenson Cancer Center, Oklahoma City, Oklahoma
Conditions: Endometrioid Cancer, Mucinous Ovarian Cancer, High Grade Serous Ovarian Cancer, Cervical Cancer, Solid Tumor
Register for Updates
Spirometric Response to Bronchial Thermoplasty in Patients With Severe Asthma
NCT02241265
Recruiting
The investigators hypothesis is that there will be improvement in FEV1 in patients with severe asthma. This is a retrospective data study that reviews preexisting medical records; no patients will be enrolled.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/06/2025
Locations: OUHSC, Oklahoma City, Oklahoma
Conditions: Asthma
Register for Updates
A Culturally Tailored Smartphone Application for African American Smokers
NCT05188287
Recruiting
The overall objectives of this research proposal, are to (a) create a smartphone application for smoking cessation (i.e., HealthyCells), which will be achieved by integrating two pre-existing evidence-based smartphone interventions, (b) create culturally tailored treatment content (i.e., messages, images, and videos) for African American smokers, and (c) evaluate the feasibility of HealthyCells at addressing smoking and sedentary behavior among African Americans. A pilot sample of African Americ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: TSET Health Promotion Research Center, Oklahoma City, Oklahoma
Conditions: Smoking Cessation
Register for Updates
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
NCT04045665
Recruiting
The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their ba... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Ascension St. John, Tulsa, Oklahoma
Conditions: Atrial Fibrillation, Stroke, Bleeding
Register for Updates
Different Doses of Naronapride Vs. Placebo in Gastroparesis
NCT05621811
Recruiting
This is a double-blind, randomized, multicenter, placebo-controlled, comparative phase II dose-finding trial. The trial will be conducted with four treatment groups in the form of a parallel group comparison and will serve to compare oral treatment with daily doses of 10, 20, or 40 mg Naronapride vs. placebo for the treatment of patients with Gastroparesis.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/04/2025
Locations: Dr Falk Investigational Site, Tulsa, Oklahoma
Conditions: Gastroparesis
Register for Updates
Safety of the Herpes Zoster Subunit Vaccine in Lupus
NCT05559671
Recruiting
This randomized, double-blind, placebo-controlled, non-inferiority crossover study will evaluate the Herpes Zoster Sunbit (HZ/su) vaccine in SLE patients in order to evaluate safety and immunogenicity in patients with variable baseline clinical activities, ages and immunosuppressant exposures. The investigators hypothesize that HZ/su administration will be non-inferior to placebo with respect to the risk of moderate or severe SLE flare(s) occurring within 24 weeks of receiving the first dose of... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
02/04/2025
Locations: Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
Conditions: Systemic Lupus Erythematosus
Register for Updates
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
NCT05557045
Recruiting
This phase 1 study will investigate the safety, dosing, and initial antitumor activity of JZP815 in participants with advanced or metastatic solid tumors harboring alterations in the MAPK pathway.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Oklahoma University, Oklahoma City, Oklahoma
Conditions: Advanced Cancer, Metastatic Cancer, Solid Tumor
Register for Updates