Rhode Island is currently home to 488 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Providence, Warwick, East Providence and Johnston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Improving Mental Health Among the LGBTQ+ Community
NCT05540067
Recruiting
The overall aim of this program of research is to improve the mental health of people who identify as LGBTQ+ by increasing their social support through a brief intervention. The purpose of the proposed project is to establish the effectiveness of our empirically-supported, brief acceptance-based behavioral therapy (ABBT). To achieve the specific aims, the investigators will conduct a fully-powered, randomized clinical trial (n=240) with two treatment arms: treatment-as-usual (TAU) vs. ABBT.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/30/2023
Locations: Brown University, Providence, Rhode Island
Conditions: Anxiety, Depression
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Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC
NCT04295811
Recruiting
The study will assess the performance of the combined system, i.e., the use of the EsoGuard assay (lab developed test) on cells collected using the EsoCheck (501k cleared device) to detect Barrett's Esophagus (BE), with or without dysplasia, and esophageal adenocarcinoma (EAC) as compared to Esophagogastroduodenoscopy (EGD) plus biopsies in both confirmed cases of BE/EAC and in controls (subjects without a prior diagnosis but undergoing screening for BE/EAC)
Gender:
Male
Ages:
50 years and above
Trial Updated:
01/23/2023
Locations: Lucid Investigative Site, Providence, Rhode Island
Conditions: Barrett Esophagus, Esophageal Adenocarcinoma, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia
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AngioSafe Peripheral CTO Crossing System Study (RESTOR-1 Study)
NCT04663867
Recruiting
The study is designed to evaluate the safety and efficacy of the AngioSafe Peripheral CTO Crossing System.
Gender:
All
Ages:
22 years and above
Trial Updated:
11/22/2022
Locations: The Miriam Hospital, Providence, Rhode Island
Conditions: Peripheral Artery Occlusion, Peripheral Arterial Disease
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Dose-escalation Study of Safety of PBCAR19B in Participants With CD19-expressing Malignancies
NCT04649112
Recruiting
This is a Phase 1, nonrandomized, open-label, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR19B in adult study participants with CD-19 expressing malignancies.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/08/2022
Locations: Lifespan Cancer Institute at Rhode Island Hospital, Providence, Rhode Island
Conditions: CD19 Expressing Malignancies, Hematologic Malignancy
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Intelligent Spine Interface
NCT04302259
Recruiting
This research study is being done to test a new device developed for spinal cord injury (SCI) patients. The purpose of this study is to collect data on how the nervous system signals travel within the spinal cord of SCI patients. Once the investigators understand that, they hope to develop a device that may help rehabilitation of SCI patients so that they can regain function in their lower limbs. This study involves some imaging studies (e.g. X-rays etc.), surgical implantation of a portion of... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
10/23/2022
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Spinal Cord Injury
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A Treatment Engagement Protocol for Psychiatrically Hospitalized Adolescents at Clinical High Risk for Psychosis
NCT04314635
Recruiting
The current study explores the development and use of a family engagement intervention for psychiatrically hospitalized adolescents with emerging psychosis symptoms. The program is designed to increase understanding of mental health symptoms and promote motivation for engagement in outpatient services. Findings from this study may inform ways to effectively educate and engage youth at clinical high risk for psychosis, and their families, in treatment that may be critical for improving future fun... Read More
Gender:
All
Ages:
Between 13 years and 18 years
Trial Updated:
10/05/2022
Locations: Bradley Hospital, East Providence, Rhode Island
Conditions: Psychosis Nos/Other
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A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)
NCT03477604
Recruiting
Randomized multicenter clinical trial consisting of two arms; one arm treated with PTA plus the MicroStent® System and one arm treated with PTA alone. Purpose to evaluate the safety and effectiveness of using the MicroStent® Peripheral Vascular Stent System, hereafter referred to as the MicroStent® System, for the treatment of infrapopliteal lesions in subjects with peripheral arterial disease.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/03/2022
Locations: Brown University, Providence, Rhode Island
Conditions: Peripheral Arterial Disease
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Amnioinfusion for Intrauterine Neuroprotection
NCT05513690
Recruiting
Hypoxic ischemic encephalopathy (HIE), a serious brain injury in infants, occurs in 2-9 per 1,000 infants after delivery. Up to 60% of infants diagnosed with HIE die and 25% of the survivors have long-term neurologic deficits. Risk factors for HIE include abnormal fetal heart tracings and intrauterine infection. Therapeutic whole-body cooling of infants with HIE is standard of care after delivery, with only 7-9 at-risk infants needing to be treated to prevent one infant from suffering long-term... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/23/2022
Locations: Women and Infant's Hospital of Rhode Island, Providence, Rhode Island
Conditions: Lactic Acidemia
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Peer-driven Intervention on PrEP
NCT05161663
Recruiting
The objective of this study is to develop an effective peer-driven intervention (PDI) approach and assess its feasibility and efficacy on pre-exposure prophylaxis (PrEP) uptake among men who have sex with men.
Gender:
Male
Ages:
18 years and above
Trial Updated:
08/13/2022
Locations: The Miriam Hospital, Providence, Rhode Island
Conditions: HIV Infections
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Assessment for Implementation Methods in Sepsis
NCT05491941
Recruiting
Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival. The current proposal is a Hybrid 2, pragmatic, cluster randomized clinical effectiveness/implementation trial evaluating mortality and respiratory failure-based outcomes, in patients admitted to the emergency department with sepsis, comparing the effectiveness of implementation... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/04/2022
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Sepsis Severe, Septic Shock
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Salivary Profiling in Infants Treated for Suspected Sepsis: The SPITSS Study
NCT05490212
Recruiting
The aim of this study is to develop a faster, safer, and more accurate method for determining if a newborn has an infection. This study involves analyzing saliva for markers of infection and inflammation known as cytokines. We will analyze infant's saliva repeatedly for inflammatory biomarkers (cytokines) within the first 36 hours of their standard of care treatment. We hypothesize that levels of these cytokines will more quickly predict which babies are truly infected and which babies are not c... Read More
Gender:
All
Ages:
All
Trial Updated:
08/04/2022
Locations: Women and Infants' Hospital, Providence, Rhode Island
Conditions: Infection; Newborn
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Improving Access to Child Anxiety Treatment
NCT03528109
Recruiting
There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the preferred treatment for youth with anxiety disorders, but outpatient services that provide this type of treatment are limited. Even for those who do have access to anxiety-specific treatment, a traditional outpatient model of treatment delivery may not be suitable. Among the numerous logistical barriers to treatment access and response is the inability to generalize treatment tools to settings outside of the of... Read More
Gender:
All
Ages:
Between 5 years and 18 years
Trial Updated:
08/02/2022
Locations: Bradley Hospital, Riverside, Rhode Island
Conditions: Obsessive-Compulsive Disorder, Anxiety Disorders, Pediatric Disorder, Anxiety, OCD, Phobia, Agoraphobia, Generalized Anxiety, Generalized Anxiety Disorder, Selective Mutism, Separation Anxiety, Social Anxiety, Social Anxiety Disorder, Panic Disorder
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