Rhode Island is currently home to 503 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Providence, Warwick, East Providence and Johnston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Clinical Evaluation of the MicroSTent® PeripherAl Vascular SteNt in Subjects With Arterial Disease Below the Knee (STAND)
NCT03477604
Recruiting
Randomized multicenter clinical trial consisting of two arms; one arm treated with PTA plus the MicroStent® System and one arm treated with PTA alone. Purpose to evaluate the safety and effectiveness of using the MicroStent® Peripheral Vascular Stent System, hereafter referred to as the MicroStent® System, for the treatment of infrapopliteal lesions in subjects with peripheral arterial disease.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/03/2022
Locations: Brown University, Providence, Rhode Island
Conditions: Peripheral Arterial Disease
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Amnioinfusion for Intrauterine Neuroprotection
NCT05513690
Recruiting
Hypoxic ischemic encephalopathy (HIE), a serious brain injury in infants, occurs in 2-9 per 1,000 infants after delivery. Up to 60% of infants diagnosed with HIE die and 25% of the survivors have long-term neurologic deficits. Risk factors for HIE include abnormal fetal heart tracings and intrauterine infection. Therapeutic whole-body cooling of infants with HIE is standard of care after delivery, with only 7-9 at-risk infants needing to be treated to prevent one infant from suffering long-term... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/23/2022
Locations: Women and Infant's Hospital of Rhode Island, Providence, Rhode Island
Conditions: Lactic Acidemia
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Peer-driven Intervention on PrEP
NCT05161663
Recruiting
The objective of this study is to develop an effective peer-driven intervention (PDI) approach and assess its feasibility and efficacy on pre-exposure prophylaxis (PrEP) uptake among men who have sex with men.
Gender:
Male
Ages:
18 years and above
Trial Updated:
08/13/2022
Locations: The Miriam Hospital, Providence, Rhode Island
Conditions: HIV Infections
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Assessment for Implementation Methods in Sepsis
NCT05491941
Recruiting
Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis "bundles" (3-hour bundle) and improved survival. The current proposal is a Hybrid 2, pragmatic, cluster randomized clinical effectiveness/implementation trial evaluating mortality and respiratory failure-based outcomes, in patients admitted to the emergency department with sepsis, comparing the effectiveness of implementation... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/04/2022
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Sepsis Severe, Septic Shock
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Salivary Profiling in Infants Treated for Suspected Sepsis: The SPITSS Study
NCT05490212
Recruiting
The aim of this study is to develop a faster, safer, and more accurate method for determining if a newborn has an infection. This study involves analyzing saliva for markers of infection and inflammation known as cytokines. We will analyze infant's saliva repeatedly for inflammatory biomarkers (cytokines) within the first 36 hours of their standard of care treatment. We hypothesize that levels of these cytokines will more quickly predict which babies are truly infected and which babies are not c... Read More
Gender:
All
Ages:
All
Trial Updated:
08/04/2022
Locations: Women and Infants' Hospital, Providence, Rhode Island
Conditions: Infection; Newborn
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Improving Access to Child Anxiety Treatment
NCT03528109
Recruiting
There is strong evidence that cognitive behavioral therapy (CBT) with exposure is the preferred treatment for youth with anxiety disorders, but outpatient services that provide this type of treatment are limited. Even for those who do have access to anxiety-specific treatment, a traditional outpatient model of treatment delivery may not be suitable. Among the numerous logistical barriers to treatment access and response is the inability to generalize treatment tools to settings outside of the of... Read More
Gender:
All
Ages:
Between 5 years and 18 years
Trial Updated:
08/02/2022
Locations: Bradley Hospital, Riverside, Rhode Island
Conditions: Obsessive-Compulsive Disorder, Anxiety Disorders, Pediatric Disorder, Anxiety, OCD, Phobia, Agoraphobia, Generalized Anxiety, Generalized Anxiety Disorder, Selective Mutism, Separation Anxiety, Social Anxiety, Social Anxiety Disorder, Panic Disorder
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Early Phase Clinical Trial to Test the Feasibility of an ACT-based Physical Activity Promotion Program for Adults With Depressive Symptoms
NCT05407935
Recruiting
The goal of the proposed project is to conduct a feasibility clinical trial comparing group-based acceptance and commitment therapy for physical activity, (ACT; ACTivity) to a time- and attention-matched standard PA intervention (i.e., PA education, goal-setting, and self-monitoring) plus relaxation training comparison condition (Relaxercise) among 60 low-active adults (ages 18-65) with elevated depressive symptoms. Participants will be randomized to treatment condition, followed for 6 months, i... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
07/18/2022
Locations: Brown University, Providence, Rhode Island
Conditions: Physical Inactivity
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Comparing Self-paced Versus Moderate Intensity Physical Activity Recommendation for Midlife Adults
NCT05285748
Recruiting
We will randomly assign (blocked on Gender (female, male, other), body mass index (BMI; overweight [25 < BMI < 30]) or obese (30 < BMI <40) and pain status (chronic pain vs not)) adults ages 50-64 into either; (a) self-selected intensity (i.e., SELF-PACED) or (b) prescribed moderate intensity (i.e., PRESCRIBED) conditions. Prior to randomization, persons responding to our ads will participate in the following: (1) telephone screening with the study research assistant (RA) to establish eligibilit... Read More
Gender:
All
Ages:
Between 50 years and 64 years
Trial Updated:
07/18/2022
Locations: Brown University, Providence, Rhode Island
Conditions: Physical Inactivity
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A Study to Monitor Ambulatory Blood Pressure Monitoring in Hypogonadal Men Treated With Nasal Testosterone Gel
NCT04976595
Recruiting
The purpose of this study is to assess the change in 24-hour ambulatory blood pressure monitoring (ABPM) between baseline (Day 0) and Day 120 following 4 months of testosterone therapy with Natesto.
Gender:
Male
Ages:
Between 18 years and 80 years
Trial Updated:
07/04/2022
Locations: Warren Alpert School of Medicine Brown University, Providence, Rhode Island
Conditions: Hypogonadism
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Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
NCT04900844
Recruiting
The objective of this pivotal study is to evaluate the safety and efficacy of the CGuard™ Carotid Stent System in the treatment of carotid artery stenosis in symptomatic and asymptomatic patients undergoing carotid artery stenting (CAS) to a performance goal developed from published CAS literature.
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
06/16/2022
Locations: Miriam Hospital, Providence, Rhode Island
Conditions: Carotid Artery Stenosis
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Biomarkers For Immune Checkpoint Inhibitors
NCT04204434
Recruiting
This is a laboratory, non-treatment study. Immune checkpoint inhibitors are a type of immunotherapy that stimulates a patients immune system to fight their cancer. Immune checkpoint inhibitors are standard, FDA approved treatment for certain types of cancers such as melanoma, lung cancer, kidney cancer and bladder cancer. The laboratories of Dr. Jack Elias and Dr. Chun Geun Lee at Brown University are studying how immune checkpoint inhibitors work.Kintai Therapeutics is a biotech company in Camb... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2022
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Advanced Cancer, Neoplasms
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Trauma Informed Guilt Reduction Therapy
NCT02512445
Recruiting
The goal of this project is to determine if a 6-session psychotherapy intervention will help Veterans feel less deployment-related guilt and less distress related to their guilt. Half of the participants will receive the guilt focused intervention and half will receive a supportive intervention. A supplemental pilot study added in FY2021 will examine the intervention for pandemic-related guilt events.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2022
Locations: VA Providence Medical Center, Providence, Rhode Island
Conditions: Guilt, Shame, Post-traumatic Stress Disorders
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