Rhode Island is currently home to 506 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Providence, Warwick, East Providence and Johnston. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of DF9001 in Patients With Advanced Solid Tumors
NCT05597839
Recruiting
DF9001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express epidermal growth factor receptor (EGFR). The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Solid Tumor, Adult
Register for Updates
A Study to Learn About Variant-Adapted COVID-19 RNA Vaccine Candidate(s) in Healthy Children
NCT05543616
Recruiting
The purpose of this clinical trial is to learn about the safety, extent of the side effects, and immune responses of the study vaccine (called variant-adapted BNT162b2 RNA-based vaccine) in healthy children. The trial is divided into 5 individual studies or substudies based on age group and prior history of COVID-19 vaccinations. All participants in each of the 5 sub-studies will receive study vaccine as a shot depending on what group they are in. * Substudy A design: Phase 1 includes participa... Read More
Gender:
ALL
Ages:
Between 6 months and 11 years
Trial Updated:
05/13/2024
Locations: Velocity Clinical Research, Providence, East Greenwich, Rhode Island
Conditions: SARS-CoV-2 Virus, Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19
Register for Updates
Using Microbiome to Predict Durvalumab Toxicity in Post- Concurrent Chemoradiation Therapy (CCRT) NSCLC Patients
NCT04680377
Recruiting
This phase IV study is hoping to determine if examining the microbiome in non-small cell lung cancer participants who will receive durvalumab can predict treatment toxicity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Rhode Island Hospital, Brown University, Providence, Rhode Island
Conditions: NSCLC, Stage III, Locally Advanced Lung Carcinoma
Register for Updates
RCT of Pain Perception With Fast and Slow Tenaculum Application
NCT05458037
Recruiting
This project will be a randomized controlled trial (RCT) measuring pain perception with two different tenaculum placement techniques on the uterine cervix. A tenaculum is an instrument used to hold the cervix (the opening to the uterus or womb) in place. The trial will measure pain perception with a Visual Analog Scale (VAS) from 0 to 100 mm for two different tenaculum placement techniques, fast and slow closure on the uterine cervix. The main objective of this study is to determine if there is... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Women and Infants Hospital, Providence, Rhode Island
Conditions: Pain, Acute, Pain, Procedural
Register for Updates
Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission
NCT05230173
Recruiting
The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ulcerative colitis \[UC\]) in symptomatic remission with moderate to severe endoscopic inflammation despite optimization of index TIM in a real-world setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Gastroenterology Associates, Providence, Rhode Island
Conditions: Ulcerative Colitis, Crohn Disease
Register for Updates
Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews
NCT06354465
Recruiting
This qualitative study investigates the potential benefits and challenges of using a once-a-month injectable medication, known as extended-release buprenorphine (XR-B), to treat individuals with opioid use disorder (OUD) within a correctional setting. The research aims to understand if XR-B can be a feasible and effective alternative to the standard daily treatment and to identify which groups within the prison population may benefit the most from this treatment. In-depth interviews are conducte... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2024
Locations: Rhode Island Department of Corrections, Cranston, Rhode Island
Conditions: Opioid Use Disorder, Criminal Justice, Treatment Adherence and Compliance
Register for Updates
Control Systems Engineering for Weight Loss Maintenance
NCT06244888
Recruiting
This project capitalizes on principles of control systems engineering to build a dynamical model that predicts weight change during weight loss maintenance using behavioral, psychosocial, and environmental indicators evaluated in a system identification experiment. A 6-month behavioral obesity treatment will be administered to produce weight loss. Participants losing at least 3% of initial body weight will be followed for an additional 12 months via daily smartphone surveys that incorporates pas... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
04/01/2024
Locations: Miriam Hospital Weight Control and Diabetes Resarch Center, Providence, Rhode Island
Conditions: Overweight and Obesity
Register for Updates
Joyuus - A Web-based Tool for Postpartum Care Self-care for Underserved Women
NCT05876559
Recruiting
The goal of this RCT is to evaluate the effectiveness of Joyuus on improving maternal functioning with postpartum moms. The main questions it aims to answer are: * The primary hypothesis is that participants of the Joyuus program will demonstrate improved functional status compared to the control arm participants at 3-month follow-up. * The secondary hypotheses are that participants using the Joyuus tool will demonstrate improvement in depression, anxiety, resilience, social support, and knowle... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
03/22/2024
Locations: Lisa Marceau, Westerly, Rhode Island
Conditions: Maternal Health
Register for Updates
Metastatic Tumor Research and Outcomes Network
NCT02830451
Recruiting
The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with metastatic spine tumor(s).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: The Warren Alpert Medical School of Brown university Department of Neurosurgery, Providence, Rhode Island
Conditions: Metastatic Spine Tumor
Register for Updates
Primary Tumor Research and Outcomes Network
NCT02790983
Recruiting
This project aims to establish a network of spine oncology centers dedicated to prospective multicenter research of patients diagnosed with a primary tumor of the spine and will include a comprehensive prospective clinical database which will serve as a shared research platform. Demographic, clinical, diagnostic, and therapeutic variables will be used to answer questions about survival and local recurrence, as well as questions about adverse events (AEs), morbidity data, and health-related quali... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/19/2024
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Spinal Column Tumor
Register for Updates
Complex Adult Deformity Surgery (CADS)
NCT04194138
Recruiting
Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University Orthopedics, Providence, Rhode Island
Conditions: Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance
Register for Updates
Reducing Alcohol Use and Sexual Dysfunction in Survivors of Sexual Trauma
NCT05599620
Recruiting
The goal of this clinical trial is to develop and evaluate the preliminary efficacy of an intervention to address alcohol use, sexual distress, and sexual assault risk among college women with a history of sexual victimization. The main questions it aims to answer are: 1) what is the feasibility of the recruitment method, research design, interventionist training methods, and delivery of the intervention; 2) does the intervention, relatively to control, the 2- and 6-month follow-up produces redu... Read More
Gender:
FEMALE
Ages:
Between 18 years and 24 years
Trial Updated:
02/14/2024
Locations: Rhode Island Hospital, Providence, Rhode Island
Conditions: Alcohol Use, Unspecified, Sexual Dysfunction, Sexual Assault
Register for Updates