Tennessee is currently home to 1927 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Nashville, Memphis, Knoxville and Chattanooga. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days
NCT04172961
Recruiting
This study will be a randomized, double-blind prospective in 3 clinical sites to compare the efficacy of two currently approved topical ophthalmic drops in the clearing central corneal staining in 90 days prior to elective cataract or LASIK surgery.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/18/2022
Locations: Toyos Clinic, Nashville, Tennessee
Conditions: Dry Eye
Register for Updates
Elderberry for Immune Support
NCT05435144
Recruiting
The purpose of this study is to confirm and quantify the effects of ElderCraft® elderberry extract on immune health.
Gender:
All
Ages:
Between 20 years and 65 years
Trial Updated:
10/10/2022
Locations: Franklin Health Research Center, Franklin, Tennessee
Conditions: Upper Respiratory Tract Infection, COVID-19, Flu, Flu Like Illness, Cold
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Rare and Atypical Diabetes Network
NCT05544266
Recruiting
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical di... Read More
Gender:
All
Ages:
All
Trial Updated:
09/14/2022
Locations: Vanderbilt University, Nashville, Tennessee
Conditions: Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
Register for Updates
Safety, Tolerability, and Efficacy of AXA1125 in NASH With Fibrosis
NCT04880187
Recruiting
This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving fat and inflammation (steatohepatitis) as well as fibrosis in subjects with non alcoholic steatohepatitis (NASH). as well as the safety and tolerability of AXA1125. Subjects will take one of two different doses of AXA1125 or a placebo twice daily, and a liver biopsy will be done at the beginning and end of the 48-week study.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: ClinSearch LLC, Chattanooga, Tennessee
Conditions: Non Alcoholic Steatohepatitis (NASH)
Register for Updates
Quantifying the Impact of the Peanut Ball on the Duration of the Active Stage of Labor
NCT05489315
Recruiting
Prolonged labor is associated with adverse maternal and fetal outcomes including infection, postpartum hemorrhage and increased NICU admission. One of the most common indications for cesarean section in the US is prolonged labor. Maternal positioning through labor facilitated by birthing balls is believed to help facilitate labor. Current data is inconclusive on whether or not the use of birthing balls is advantageous in a statistically significant manner. In this prospective randomized control... Read More
Gender:
Female
Ages:
16 years and above
Trial Updated:
09/05/2022
Locations: Regional One Health Outpatient Center, Memphis, Tennessee
Conditions: Labor Onset and Length Abnormalities, Prolonged Labor, Labor Long, Labor; Poor
Register for Updates
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.
NCT05401357
Recruiting
This is a randomized, double-blind, two-treatment, single-period, parallel design, multiple dose at multiple clinical trial sites designed to demonstrate bioequivalence with clinical endpoint in subjects with chronic open-angle glaucoma or ocular hypertension in both eyes. Test Product - Bimatoprost ophthalmic solution, 0.01% of Amneal EU, Limited Reference Product - LUMIGAN® (bimatoprost ophthalmic solution) 0.01% of Allergan, Inc.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/09/2022
Locations: Toyos Clinic, Nashville, Tennessee
Conditions: Glaucoma, Open-Angle, Ocular Hypertension
Register for Updates
The JULI Registry--Hemp and Cannabis Observational Registry
NCT04726254
Recruiting
The JuLi Registry seeks to fill some of the gaps associated with the clinical use of CBD (cannabidiol) and other cannabinoid formulations including THC and others. The overarching goal of this Registry is to rapidly advance research and understanding of the use of cannabis and hemp-based formulations, in the clinical community setting, when it is utilized to manage the symptoms of cancer treatment and other underlying health issues. These symptoms include nausea, neuropathy, and sleeplessness an... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
07/15/2022
Locations: Nashville Breast Center, Nashville, Tennessee
Conditions: Chronic Pain, Appetite Disorders, Neuropathy, Menopausal Syndrome, Anxiety, Sleep Disturbance, Nausea
Register for Updates
MIP Versus PCNL for Kidney Stone Disease
NCT04767919
Recruiting
The decision to use standard percutaneous nephrolithotomy (PCNL) versus mini-percutaneous nephrolithotomy (MIP) has been a subject of much debate in the urological community. The investigators propose a randomized controlled trial to compare the operative outcomes and complications of mini-percutaneous nephrolithotomy (mini-PCNL) versus standard PCNL for renal stones. The results of this study will help guide the decision making regarding these two procedures in the US population and provide fur... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/12/2022
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Kidney Stone
Register for Updates
Impact of Jump Start Nutrition Program on Weight Loss and Associated Measures
NCT05443269
Recruiting
The purpose of the proposed study is to evaluate the impact of the Jump Start program to facilitate weight loss in a sample of overweight and obese men and women. The study will not only evaluate weight loss and changes in body-shape but will also assess the type of weight lost (fat vs. lean mass) and other health measures affected by obesity including lipids, glucose, insulin, resting heart rate and blood pressure, and perceived wellness. This study will contribute to the general weight loss li... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
06/29/2022
Locations: Center for Nutraceutical and Dietary Supplement Research, Memphis, Tennessee
Conditions: Weight Loss
Register for Updates
Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting
NCT04900844
Recruiting
The objective of this pivotal study is to evaluate the safety and efficacy of the CGuard™ Carotid Stent System in the treatment of carotid artery stenosis in symptomatic and asymptomatic patients undergoing carotid artery stenting (CAS) to a performance goal developed from published CAS literature.
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
06/16/2022
Locations: Ballad CVA Heart Institute, Kingsport, Tennessee
Conditions: Carotid Artery Stenosis
Register for Updates
Non-Guided vs. Guided Surgery to Immediately Loaded PrimeTaper Implants in Partially Edentulous Patients
NCT05264545
Recruiting
A 510k approved dental device for subjects requiring single or multiple tooth replacement with implants where immediate restoration/loading is preferred.
Gender:
All
Ages:
25 years and above
Trial Updated:
05/25/2022
Locations: Perio & Implant Associates of Middle TN, Nashville, Tennessee
Conditions: Partially Edentulous Maxilla or Mandible
Register for Updates
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
NCT04857359
Recruiting
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on the Unified Dyskinesia Rating Scale (UDysRS). Patients who complete the 12-week blinded treatment period may have the option to roll into an open-label safety extension study for an additional 12-month treatment period.
Gender:
All
Ages:
Between 30 years and 85 years
Trial Updated:
05/18/2022
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Parkinson Disease, Dyskinesia, Drug-Induced, Dyskinesias
Register for Updates