There are currently 69 active clinical trials seeking participants for Insomnia research studies. The states with the highest number of trials for Insomnia participants are California, Florida, Texas and Ohio.
Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis
NCT06428006
Recruiting
The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical function, psychological well-being, quality of life, and occupational function, as well as increased prevalence of fatigue, pain, depression, and anxiety. The objective of the proposed study is to determine the efficacy of cognitive behavioral therapy for insomnia (CBT-I) to... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/16/2025
Locations: University of Kansas Medical Center, Kansas City, Kansas
Conditions: Multiple Sclerosis, Insomnia
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Sleep Treatment Education Program for Cancer Survivors: STEP-Together
NCT06736548
Recruiting
This single-arm research study of off-treatment cancer survivors with self-reported symptoms of insomnia will test the Sleep Treatment Education Program Together (STEP-Together) intervention which is delivered as a synchronous group session by videoconference.
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/01/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Insomnia, Insomnia Chronic, Survivorship
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Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
NCT06981195
Recruiting
The goal of this clinical trial is to learn about how certain medications used to treat insomnia (e.g., Lemborexant) impact sleep, mood, and behavior in men and women with Opioid Use Disorder who are taking prescribed buprenorphine. The main questions it aims to answer are: 1. What is the effect of the study drug (lemborexant) on sleep outcomes? 2. What is the effect of the study drug (lemborexant) on impulsive behavior (as measured by computer test performance)? 3. What is the effect of the st... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: VCU Institute for Drug and Alcohol Studies, Richmond, Virginia
Conditions: Opioid Use Disorder, Opioid Use, Insomnia, Orexin Antagonist
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Wearable tES for Insomnia
NCT06100185
Recruiting
The purpose of this study is to investigate the ability of a translational device, Teledyne PeakSleep, to reduce sleep onset latency, reduce time awake after sleep onset and improve restfulness and the subjective benefits of sleep in a patient population with insomnia via transcranial direct current stimulation (tDCS) applied to frontal lobe circuits.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/25/2025
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Insomnia
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Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse
NCT06609369
Recruiting
The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
06/11/2025
Locations: Connecticut Mental Health Center, New Haven, Connecticut +1 locations
Conditions: Tobacco Use, Tobacco Cessation, Insomnia
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Enhancing Hypnotic Medication Discontinuation in Primary Care
NCT06435520
Recruiting
Many individuals with insomnia seek treatment in primary care settings, where they often receive prescription hypnotic medications as their first and sometimes only treatment. However, extended use of these medications can lead to reliance and increased health risks, such as falls and cognitive impairments. While evidence-based approaches like physician-supervised medication tapering exist, they're not widely available in primary care. Most primary care providers are willing to explore non-drug... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/03/2025
Locations: National Jewish Health, Denver, Colorado
Conditions: Insomnia, Hypnotic Dependence
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Digital CBT for Insomnia and Depression
NCT05456607
Recruiting
This study has two primary objectives, each of which addresses critical clinical and research gaps for individuals who have co-occurring insomnia and depression. The first objective is to address whether sequential treatment of insomnia and depression is superior to a single treatment for either depression or for insomnia, and if so, which treatment sequence is optimal. The second objective is to determine if there are heterogeneity of treatment effects; that is, variation in which interventions... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: University of Rochester Sleep Research Laboratory, Rochester, New York
Conditions: Depression, Insomnia
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Pimavanserin for Insomnia in Veterans With PTSD
NCT05441280
Recruiting
This is a preliminary randomized, double-blind, placebo-controlled trial comparing pimavanserin 34mg at bedtime vs. placebo for the treatment of insomnia associated with post-traumatic stress disorder.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
05/29/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas
Conditions: Post-traumatic Stress Disorder, Insomnia
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Implementation & Dissemination of a Digital Health Intervention for Adolescent Sleep
NCT06840444
Recruiting
The goal of this study is to form a Teen Advisory Board (TAB), who will partner with our study team to co-design a beta-test a new prototype of the Firefly program, a mobile-native insomnia cognitive behavioral therapy intervention for teens. This new prototype will have addressed issues that adolescents who had used the first version of the program deemed to be barriers to engaging with the treatment.
Gender:
ALL
Ages:
Between 13 years and 18 years
Trial Updated:
05/28/2025
Locations: Kansas University Medical Center, Kansas City, Kansas
Conditions: Insomnia, Adolescent, Digital Health
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Move and Snooze: Adding Insomnia Treatment to an Exercise Program to Improve Pain Outcomes in Older Adults With Knee Osteoarthritis
NCT06580561
Recruiting
This research will compare the effectiveness of a remotely delivered personalized exercise coaching plus an evidence-based sleep improvement intervention to remotely delivered personalized exercise coaching alone for knee osteoarthritis pain. The study team hypothesize that the combined intervention will result in greater improvements in patient-reported pain intensity, recorded with real-time data capture, than remotely delivered exercise coaching alone.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/14/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Knee Osteoarthritis, Insomnia
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Sleep Mechanisms Of Regulating Emotions
NCT06373718
Recruiting
This project is the second phase of a two-phased project investigating the impact of a proven sleep intervention, Cognitive Behavioral Therapy for Insomnia (CBT-I) on engagement of the emotion regulation brain network as a putative mechanistic target.
Gender:
ALL
Ages:
Between 25 years and 60 years
Trial Updated:
05/07/2025
Locations: Stanford University, Palo Alto, California
Conditions: Insomnia, Depression
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Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients
NCT06375265
Recruiting
The Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST) is a pilot randomized, controlled, singled-blinded (participant) trial in major orthopedic joint surgery patients that will build on a previously clinically tested cognitive behavioral therapy for insomnia (CBT-I) mobile application paired with a wearable device (wrist actigraphy).
Gender:
ALL
Ages:
65 years and above
Trial Updated:
05/05/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Insomnia, Postoperative Delirium, Delayed Neurocognitive Recovery, Postoperative Neurocognitive Disorder
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