Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)
NCT05565833
Recruiting
This randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education condition on sleep and cognition. Internet-based recr... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
04/20/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Insomnia, Cognitive Dysfunction, Mild Cognitive Impairment, Sleep Initiation and Maintenance Disorders, Sleep Disorders, Intrinsic, Dyssomnias, Sleep Wake Disorders, Nervous System Diseases, Alzheimer Disease
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Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD)
NCT05457790
Recruiting
Research Type: Clinical Trial Background: People with sickle cell disease (SCD) have many health challenges. Also, they often have trouble sleeping. Acceptance and commitment therapy (ACT) might help people with SCD to improve their sleep problems. Objective: To see how well ACT works in people with SCD and sleep problems and to find out how they feel about it. Eligibility: People between the ages of 18 and 55 with SCD and trouble sleeping. Design: The study is remote. Participants will... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
12/01/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Sickle Cell Disease, Sickle Cell Anemia, Insomnia, Sleeplessness, Transient Insomnia, Nonorganic Insomnia, Chronic Insomnia
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SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid
NCT03954210
Recruiting
The objective of this study is to compare the efficacy of a sleep intervention on improving cognitive function in older adults with symptoms of insomnia, determine the association between change in sleep measures and change in cognitive function, and examine the efficacy of the sleep intervention on reducing the rate of Aβ deposition. Participants, ages 60-85, will be randomly assigned to a six-week sleep intervention program. A sub-group of fifty participants will undergo Florbetapir-Positron-e... Read More
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
11/28/2023
Locations: University of Kansas Medical Center- Sleep, Health and Wellness Laboratory, Kansas City, Kansas
Conditions: Insomnia
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Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder
NCT05423717
Recruiting
This study assesses the efficacy, safety, and pharmacokinetics of multiple-dose oral administration of daridorexant in pediatric subjects aged 10 to < 18 years with insomnia disorder.
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
11/17/2023
Locations: Banner - University Medical Center Tucson, Tucson, Arizona +25 locations
Conditions: Insomnia
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The Reducing Risk Study
NCT03665337
Recruiting
The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
11/16/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Delayed Sleep Phase
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Suvorexant and Sleep/Delirium in ICU Patients
NCT04092894
Recruiting
Investigators will evaluate the efficacy of postoperative oral suvorexant treatment on nighttime wakefulness after persistent sleep onset (WASO) among adult cardiac surgical patients recovering in the cardiac intensive care unit (ICU). The study include patients ≥ 60 years old undergoing coronary artery bypass graft surgery (CABG), with or without valve surgery (aortic or mitral). Patients will receive either oral suvorexant or placebo for 7 nights starting the night after extubation. The primar... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
11/15/2023
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts +1 locations
Conditions: Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
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Perinatal Research on Improving Sleep and Mental Health
NCT05596318
Recruiting
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep hygiene education (SHE) for preventing perinatal depression? Is the effect of digital CBT-I on perinatal depression mediated through prenatal insomnia symptom improvement? Is the effect of digital CBT-I on perinatal depression moderated by baseline depres... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Insomnia, Depression
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eHealth Insomnia Intervention for Adult Survivors of Childhood Cancer
NCT04317742
Recruiting
There is evidence that survivors of childhood cancer have a high prevalence of poor sleep, including symptoms of insomnia. Insomnia is highly comorbid and has been associated with impaired cognitive performance, a range of psychiatric disorders, cardiovascular disease, and reduced quality of life. However, we still lack knowledge about the direct impact of available internet-based insomnia treatment programs for survivors of childhood cancer experiencing insomnia, in addition to how improving in... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/13/2023
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Childhood Cancer, Insomnia, Neurocognitive Impairment, Survivorship, Late Effect, Sleep
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Insomnia Treatment and EMA (Ecological Momentary Assessment) Outcomes
NCT05908526
Recruiting
The goal of this study is to examine the impact of suvorexant, an FDA-approved insomnia medication, on daytime symptoms (as measured by the Daytime Insomnia Symptoms Scale: cognition, positive mood, negative mood, and fatigue/sleepiness) among older adults with insomnia. The primary hypothesis is that relative to placebo, suvorexant will improve sleep and daytime symptoms. The word "placebo" refers to a harmless pill with no therapeutic effect.
Gender:
All
Ages:
Between 60 years and 85 years
Trial Updated:
11/13/2023
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Insomnia
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RISE: A Remote Study of Insomnia Treatment in Crohn's Disease
NCT05956158
Recruiting
The purpose of this study is to assess whether the investigators can treat insomnia in people with Crohn's disease, and if insomnia treatment can make other things better, like pain or inflammation.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/07/2023
Locations: Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Conditions: Insomnia, Crohn Disease
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Comparing Virtual Yoga to Standard Care on Insomnia Among Cancer Survivors
NCT04458194
Recruiting
This feasibility phase II randomized controlled trial examines the preliminary efficacy of our standardized four-week YOCAS©® (Yoga for Cancer Survivors) intervention that is delivered virtually on insomnia and sleep quality in cancer survivors. Insomnia can be described as excessive daytime napping, difficulty falling asleep, difficulty staying asleep, or waking up earlier than desired. The vast majority of patients with cancer experience some form of sleep impairment post-treatment. Yoga is s... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/06/2023
Locations: Bassett Research Institute, Cooperstown, New York +1 locations
Conditions: Insomnia
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Wearable tES for Insomnia
NCT06100185
Recruiting
The purpose of this study is to investigate the ability of a translational device, Teledyne PeakSleep, to reduce sleep onset latency, reduce time awake after sleep onset and improve restfulness and the subjective benefits of sleep in a patient population with insomnia via transcranial direct current stimulation (tDCS) applied to frontal lobe circuits.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/02/2023
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Insomnia
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