There are currently 128 active clinical trials seeking participants for Multiple Sclerosis research studies. The states with the highest number of trials for Multiple Sclerosis participants are New York, Florida, California and Ohio.
Safety of Bryostatin in Patients With MS
NCT06190912
Recruiting
This is a single-site, single-arm, single-dose, Phase 1 study of the safety of bryostatin in participants with multiple sclerosis (MS) receiving any disease modifying therapy (DMT).
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/01/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Multiple Sclerosis
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Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
NCT05964829
Recruiting
The purpose of this research is to support the clinical value of the Cionic Neural Sleeve for individuals diagnosed with multiple sclerosis (MS).
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
02/05/2024
Locations: Cleveland State University, Cleveland, Ohio
Conditions: Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
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Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
NCT06141486
Recruiting
The purpose of this randomized, double-blind, placebo-controlled, parallel group study is to determine the efficacy of frexalimab in delaying the disability progression and the safety up to approximately 51 months administration of study intervention compared to placebo in male and female participants with nrSPMS (aged 18 to 60 years at the time of enrollment). People diagnosed with nrSPMS are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion crite... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/08/2024
Locations: Alabama Neurology Associates Site Number : 8400115, Birmingham, Alabama +30 locations
Conditions: Multiple Sclerosis
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An Individualized-health eLibrary App for People With Multiple Sclerosis
NCT05124600
Recruiting
The purpose of this study is to assess the effectiveness after using a new individualized-health e-library app named SavvyHealth among people with multiple sclerosis.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2024
Locations: University of Illinois Urbana-Champaign, Champaign, Illinois
Conditions: Multiple Sclerosis
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A Health Action Process Approach Online Intervention for People With Multiple Sclerosis
NCT05124522
Recruiting
The purpose of this study is to implement the person-centered internet-based Health Action Process Approach to promoting physical activity in people with Multiple Sclerosis (i.e., eHAPA-MS online intervention) and assess the intervention's effectiveness and adherence.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2024
Locations: University of Illinois Urbana-Champaign, Champaign, Illinois
Conditions: Multiple Sclerosis
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31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.
NCT03993171
Recruiting
REPAIR-MS is a single-center open label, sequential group, investigator and patient blinded study to assess the CNS metabolic effects, safety, pharmacokinetics, and pharmacodynamics of CNM-Au8 in patients who have been diagnosed with Multiple Sclerosis (MS) within fifteen (15) years of Screening. The primary endpoint for this study changes from baseline to week 12 in CNS metabolic changes, based on 31P-MRSimaging.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
05/07/2024
Locations: University of Texas Southwestern, Dallas, Texas
Conditions: Multiple Sclerosis
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A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis or Progressive Forms of Multiple Sclerosis
NCT06220201
Recruiting
The purpose of this study is to evaluate the safety, tolerability, efficacy, and drug levels of CC-97540 in participants with Relapsing Forms of Multiple Sclerosis (RMS) or Progressive Forms of Multiple Sclerosis (PMS).
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/07/2024
Locations: Local Institution - 0011, Birmingham, Alabama +34 locations
Conditions: Multiple Sclerosis
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Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis
NCT06355804
Recruiting
The overall objective of the current study is to determine the efficacy of a 16-week remotely delivered lifestyle behavioral intervention compared with a control condition (i.e., waitlist control) in persons newly diagnosed with MS (disease duration ≤ 2 years). Specific Aim 1: To evaluate the changes in self-report and device-measured physical activity after the 16-week remotely delivered physical activity behavior change intervention compared with a control condition (i.e., waitlist control) i... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Multiple Sclerosis
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Neuroprotection With N-acetyl Cysteine for Patients With Progressive Multiple Sclerosis
NCT05122559
Recruiting
This study evaluates the effectiveness of N-acetyl cysteine (NAC) in the treatment of progressive multiple sclerosis. Half of the patients will receive NAC, while the other half will receive a placebo.
Gender:
All
Ages:
Between 40 years and 70 years
Trial Updated:
05/06/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Multiple Sclerosis, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
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Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis
NCT06264336
Recruiting
Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden.
Gender:
All
Ages:
21 years and above
Trial Updated:
05/06/2024
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Multiple Sclerosis
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Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
NCT05051618
Recruiting
The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 years of age. The investigators will enroll a total of 146 participants. This is a Phase-II trial that compares the efficacy of an exercise training program (POWER-MS) compared with a stretching progr... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
05/05/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Multiple Sclerosis, Major Depressive Disorder
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Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis
NCT04518657
Recruiting
We propose a highly-informed, well-designed randomized controlled trial (RCT) that is critical for providing Class I evidence regarding an Internet-delivered physical activity (PA) intervention as a behavioral approach for managing slowed cognitive processing speed (CPS; the most common and perhaps most burdensome MS-related cognitive impairment) and its second learning and memory, symptomatic, and quality of life (QOL) correlates among fully-ambulatory persons with multiple sclerosis (MS) who p... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/05/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Multiple Sclerosis
Register for Updates