There are currently 128 active clinical trials seeking participants for Multiple Sclerosis research studies. The states with the highest number of trials for Multiple Sclerosis participants are New York, Florida, California and Ohio.
Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS
NCT05500963
Recruiting
The objective of the randomized, sham-controlled trial will be to evaluate the effectiveness of treatment with transcutaneous electrical nerve stimulation (TENS) at reducing the level of fatigue experienced by people with MS.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
05/25/2023
Locations: University of Colorado, Boulder, Colorado
Conditions: Multiple Sclerosis
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Kesimpta (Ofatumumab) Pregnancy Registry
NCT05634967
Recruiting
The Kesimpta Pregnancy Registry is an observational, exposure cohort designed study to examine pregnancy and infant outcomes in women and infants who are exposed to Kesimpta (ofatumumab) during pregnancy to treat MS.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/10/2023
Locations: Novartis Investigative Site, La Jolla, California
Conditions: Multiple Sclerosis, Pregnancy
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Post-Authorization Safety Study for Assessment of Pregnancy Outcomes in Patients Treated With Mayzent
NCT04933552
Recruiting
This study will utilize a prospective, observational, exposure cohort design to examine pregnancy and infant outcomes in women and infants who are exposed to siponimod during pregnancy to treat MS.
Gender:
Female
Ages:
All
Trial Updated:
05/10/2023
Locations: Novartis Investigative Site, La Jolla, California
Conditions: Multiple Sclerosis
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Multiple Sclerosis Falls Insight Track
NCT05837949
Recruiting
The purpose of this study is to develop an application: MS Falls Insight Track (MS FIT) which allows patients to log their falls and near falls, view their MS relevant data and responses to the clinic intake survey as well as communicate with their care team about falls and receive educational material on falls prevention.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/27/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Multiple Sclerosis
Register for Updates
Aerobic Exercise for Remyelination in Multiple Sclerosis
NCT04539002
Recruiting
This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
04/25/2023
Locations: Oregon Health & Science University, Portland, Oregon
Conditions: Multiple Sclerosis, Sclerosis, Demyelinating Diseases, Autoimmune Diseases of the Nervous System, Nervous System Diseases, Demyelinating Autoimmune Diseases, CNS, Exercise
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Gut Microbiome and Depression
NCT05808101
Recruiting
The purpose of this project is to determine if specific gut microbiome or gut-derived metabolites are associated with depression in patients with Multiple Sclerosis (pwMS). Mechanistically, the investigators further hypothesize that depression in pwMS is related to decreased abundance of gut bacteria with GABA-producing activities and/or with anti-inflammatory properties. To determine if the presence of depression in pwMS is associated with specific gut microbiome, gut-derived metabolites or per... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2023
Locations: Washington University in St Louis, Saint Louis, Missouri
Conditions: Multiple Sclerosis, Depression
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Prebiotic vs Probiotic in Multiple Sclerosis
NCT04038541
Recruiting
This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with MS and Clinically Isolated Syndrome (CIS). Eligible patients will take 6 weeks of two different supplements - Prebiotics and Probiotics. Participants will be randomly assigned to take either of two agents for 6 weeks as their first supplement. Then, participants enter a 6-week washout perio... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/15/2023
Locations: Columbia University Irving Medical Center, New York, New York +1 locations
Conditions: Multiple Sclerosis, Clinically Isolated Syndrome (CIS)
Register for Updates
High-Intensity, Dynamic-stability Gait Training in People With Multiple Sclerosis
NCT05735691
Recruiting
The goal of this clinical trial is to improve walking speed, balance, and walking in the community for people with multiple sclerosis. This trial involves intense exercise combined with walking on a shaky treadmill. Walking on a shaky treadmill helps to practice balance and intense exercise promotes the ability to walk faster and farther. In this study, participants will train with a combination of high or low intensity, and with a stable or shaky treadmill. Walking speed and endurance, balance... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/09/2023
Locations: Rehabilitation Hospital of Indiana, Indianapolis, Indiana +1 locations
Conditions: Multiple Sclerosis
Register for Updates
PTNS for Female Patients Suffering From Multiple Sclerosis
NCT05422625
Recruiting
This is a pilot, single blind, randomized, sham-controlled trial to assess the benefit of PTNS in treating OAB symptoms in MS patients. The data generated by this study would provide support for a future multi-institutional, randomized prospective trial.
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: Beaumont Hospital - Royal Oak, Royal Oak, Michigan
Conditions: Multiple Sclerosis, Overactive Bladder
Register for Updates
The Effect of Motor Imagery on Balance in Persons With Multiple Sclerosis
NCT05615207
Recruiting
This study will investigate if the use of motor imagery to practice a balance task is as effective as physically practicing balance tasks as measured by the Berg Balance Scale (BBS) in persons with MS. A secondary purpose is to investigate if using a motor imagery balance intervention will limit fatigue typically experienced with physical movement in this population.
Gender:
All
Ages:
All
Trial Updated:
02/03/2023
Locations: Dominican University New York, Orangeburg, New York
Conditions: Falls, Motor Imagery, Multiple Sclerosis, Balance, Fatigue
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Risk Factors in Early Multiple Sclerosis
NCT03586986
Recruiting
The central hypothesis of this protocol is that it is possible, using First Degree Relatives (FDRs) of patients with Multiple Sclerosis (MS) and assessing a variety of both known and unknown risk factors for MS, to define a risk algorithm for earliest signs of development of MS. The plan will be to do an abbreviated brain Magnetic Resonance Imaging (MRI) scan in asymptomatic, young FDRs, analyze blood for a variety of immunological, genetic, neuroaxonal damage, metabolic, viral serology and othe... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
02/02/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome, Radiologically Isolated Syndrome
Register for Updates
Longitudinal Cognitive Assessment by BoCA
NCT04114994
Recruiting
The Boston Cognitive Assessment (BoCA) is a self-administered online test intended for longitudinal cognitive monitoring. BoCA uses random not-repeating tasks to minimize learning effects. BoCA was developed to evaluate the effects of treatment in longitudinal clinical trials and available gratis to individuals and professionals.
Gender:
All
Ages:
50 years and above
Trial Updated:
01/31/2023
Locations: Andrey Vyshedskiy, Miami, Florida
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia, Frontotemporal Dementia, Parkinson Disease, Multiple Sclerosis, TBI
Register for Updates