There are currently 129 active clinical trials seeking participants for Multiple Sclerosis research studies. The states with the highest number of trials for Multiple Sclerosis participants are Florida, New York, California and Ohio.
Effect of Cooling on Balance Performance in Multiple Sclerosis
NCT06094855
Recruiting
The goal of this observational study to examine the effects of cooling on balance in persons with Multiple Sclerosis. Persons with Multiple Sclerosis frequently have problems with balance leading to falls and related injuries, as well as avoidance of activities that may challenge balance. Persons with Multiple Sclerosis are also well known to experience worsening of their symptoms when they become too warm, a condition known as thermosensitivity. This suggests that heat may worsen balance and in... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/14/2023
Locations: Hunter College, Physical Therapy Department, City University of New York, New York, New York
Conditions: Multiple Sclerosis
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A Study to Evaluate the Safety, Tolerability, and Exploratory Efficacy of IMS001 in Subjects With Multiple Sclerosis
NCT04956744
Recruiting
This is a Phase 1 study of IMS001, given as a single dose to subjects with Multiple Sclerosis who experience inadequate response and/or intolerability to disease modifying treatments. IMS001 is a human embryonic cell derived (hESC) mesenchymal stem cell (MSC). MSCs have the potential to modulate disease course.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
09/26/2023
Locations: Shepherd Center, Atlanta, Georgia +2 locations
Conditions: Multiple Sclerosis
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High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners
NCT05951985
Recruiting
Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive. This is an issue for both them and their care partners as their health is often linked. This study aims to examine the long-term physical and psychosocial effects of structured, group-based, high intensity functional training (HIFT) exercise for people with neurologic diagnoses and their care partners.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/08/2023
Locations: Arkansas Colleges of Health Education, Fort Smith, Arkansas
Conditions: Neurologic Disorder, Parkinson Disease, Spinal Cord Injuries, Spina Bifida, Stroke, Poliomyelitis, Multiple Sclerosis, Brain Injuries
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Meeting an Unmet Need in Multiple Sclerosis
NCT05953519
Recruiting
The primary objectives of this study is to examine the efficacy of the Unified Protocol in decreasing depression and anxiety among individuals with MS and the secondary outcomes (e.g., improved well-being, QOL, coping, etc.) that may occur in tandem.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/12/2023
Locations: Kessler Foundation, East Hanover, New Jersey
Conditions: Multiple Sclerosis
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The Effect of Motor Imagery on Balance in Persons With Multiple Sclerosis
NCT05615207
Recruiting
This study will investigate if the use of motor imagery to practice a balance task is as effective as physically practicing balance tasks as measured by the Berg Balance Scale (BBS) in persons with MS. A secondary purpose is to investigate if using a motor imagery balance intervention will limit fatigue typically experienced with physical movement in this population.
Gender:
All
Ages:
All
Trial Updated:
02/03/2023
Locations: Dominican University New York, Orangeburg, New York
Conditions: Falls, Motor Imagery, Multiple Sclerosis, Balance, Fatigue
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Risk Factors in Early Multiple Sclerosis
NCT03586986
Recruiting
The central hypothesis of this protocol is that it is possible, using First Degree Relatives (FDRs) of patients with Multiple Sclerosis (MS) and assessing a variety of both known and unknown risk factors for MS, to define a risk algorithm for earliest signs of development of MS. The plan will be to do an abbreviated brain Magnetic Resonance Imaging (MRI) scan in asymptomatic, young FDRs, analyze blood for a variety of immunological, genetic, neuroaxonal damage, metabolic, viral serology and othe... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
02/02/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome, Radiologically Isolated Syndrome
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Comparison of Two Physical Activity Interventions in Individuals With Multiple Sclerosis
NCT02496416
Recruiting
This study will examine the effectiveness of aquatic therapy on a range of MS-related symptoms such as cognition, mood, fatigue and quality of life (QOL).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2022
Locations: Kessler Foundation, East Hanover, New Jersey
Conditions: Multiple Sclerosis
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Computerized Cognitive Rehabilitation in MS Patients
NCT03729713
Recruiting
This study examines a home-based computerized cognitive rehabilitation intervention in adults with multiple sclerosis compared to placebo (videogame). Patients are assessed through pre-and post neuropsychological testing.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/16/2022
Locations: Robert Wood Johnson Medical School, New Brunswick, New Jersey
Conditions: Multiple Sclerosis, Cognitive Impairment
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Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve
NCT05605951
Recruiting
The goal of this observational study is to longitudinally investigating subjects with inaugural acute optic neuritis (ON). The main questions it aims to answer are: Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? How differ clinical, structural, and laboratory biomarkers in subjects with acute ON, including cli... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/31/2022
Locations: University of Colorado School of Medicine, Aurora, Colorado +25 locations
Conditions: Demyelinating Diseases, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Optic Neuritis
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Reinventing Yourself With Multiple Sclerosis (MS)
NCT05195320
Recruiting
Given the knowledge that detriments in QOL, well-being, and participation are common in MS and attributable in a large part to individual, person-specific factors (e.g., self-efficacy), efforts to develop interventions aimed at addressing these factors is well needed and likely to have a significant impact. The proposed investigation will consist of two phases involving participant recruitment and data collection. Phase 1 will consist of a focus group aimed at identifying the unique needs of ind... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/12/2022
Locations: Kessler Foundation, East Hanover, New Jersey
Conditions: Multiple Sclerosis
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High Intensity Interval Gait Training in Multiple Sclerosis
NCT05560880
Recruiting
Over 90% of persons with MS (pwMS) complain of difficulty with walking. High intensity interval gait training (HIIGT), where persons alternate brief periods of walking at high speeds with periods of rest has been found to improve walking in other neurologic diagnoses. However its impact on pwMS is not known. Most gait training in MS is done continuously at a slower pace. The purpose of this study is to compare the effects of HIIGT to traditional Moderate Intensity Continuous Gait Training (MICGT... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/05/2022
Locations: Hunter College, New York, New York
Conditions: Multiple Sclerosis
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Genes and Environment in Multiple Sclerosis
NCT01353547
Recruiting
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS wil... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/16/2022
Locations: National Institute of Neurological Disorders and Stroke, Bethesda, Maryland +4 locations
Conditions: Multiple Sclerosis
Register for Updates