There are currently 128 active clinical trials seeking participants for Multiple Sclerosis research studies. The states with the highest number of trials for Multiple Sclerosis participants are New York, Florida, California and Ohio.
The Effect of Motor Imagery on Balance in Persons With Multiple Sclerosis
NCT05615207
Recruiting
This study will investigate if the use of motor imagery to practice a balance task is as effective as physically practicing balance tasks as measured by the Berg Balance Scale (BBS) in persons with MS. A secondary purpose is to investigate if using a motor imagery balance intervention will limit fatigue typically experienced with physical movement in this population.
Gender:
All
Ages:
All
Trial Updated:
02/03/2023
Locations: Dominican University New York, Orangeburg, New York
Conditions: Falls, Motor Imagery, Multiple Sclerosis, Balance, Fatigue
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Risk Factors in Early Multiple Sclerosis
NCT03586986
Recruiting
The central hypothesis of this protocol is that it is possible, using First Degree Relatives (FDRs) of patients with Multiple Sclerosis (MS) and assessing a variety of both known and unknown risk factors for MS, to define a risk algorithm for earliest signs of development of MS. The plan will be to do an abbreviated brain Magnetic Resonance Imaging (MRI) scan in asymptomatic, young FDRs, analyze blood for a variety of immunological, genetic, neuroaxonal damage, metabolic, viral serology and othe... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
02/02/2023
Locations: University of Colorado Anschutz Medical Campus, Aurora, Colorado
Conditions: Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome, Radiologically Isolated Syndrome
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Longitudinal Cognitive Assessment by BoCA
NCT04114994
Recruiting
The Boston Cognitive Assessment (BoCA) is a self-administered online test intended for longitudinal cognitive monitoring. BoCA uses random not-repeating tasks to minimize learning effects. BoCA was developed to evaluate the effects of treatment in longitudinal clinical trials and available gratis to individuals and professionals.
Gender:
All
Ages:
50 years and above
Trial Updated:
01/31/2023
Locations: Andrey Vyshedskiy, Miami, Florida
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia, Frontotemporal Dementia, Parkinson Disease, Multiple Sclerosis, TBI
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Comparison of Two Physical Activity Interventions in Individuals With Multiple Sclerosis
NCT02496416
Recruiting
This study will examine the effectiveness of aquatic therapy on a range of MS-related symptoms such as cognition, mood, fatigue and quality of life (QOL).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/01/2022
Locations: Kessler Foundation, East Hanover, New Jersey
Conditions: Multiple Sclerosis
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Computerized Cognitive Rehabilitation in MS Patients
NCT03729713
Recruiting
This study examines a home-based computerized cognitive rehabilitation intervention in adults with multiple sclerosis compared to placebo (videogame). Patients are assessed through pre-and post neuropsychological testing.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/16/2022
Locations: Robert Wood Johnson Medical School, New Brunswick, New Jersey
Conditions: Multiple Sclerosis, Cognitive Impairment
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User-friendliness of a Portable Driving Simulator
NCT03969927
Recruiting
The use of simulators to retrain driving skills of patients with stroke, Parkinson's disease (PD), or multiple sclerosis (MS) is very limited because of cost, space required, and incidence of simulator sickness in high fidelity simulators. The Principal investigator recently developed a low cost low fidelity portable driving simulator (PDS). In this pilot study, the study team will (1) determine the ease of use and occurrence of simulator sickness while operating the low fidelity PDS in a clinic... Read More
Gender:
All
Ages:
Between 25 years and 75 years
Trial Updated:
11/01/2022
Locations: Abiodun Akinwuntan, Kansas City, Kansas
Conditions: Parkinson Disease, Multiple Sclerosis, Stroke
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Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve
NCT05605951
Recruiting
The goal of this observational study is to longitudinally investigating subjects with inaugural acute optic neuritis (ON). The main questions it aims to answer are: Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? How differ clinical, structural, and laboratory biomarkers in subjects with acute ON, including cli... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/31/2022
Locations: University of Colorado School of Medicine, Aurora, Colorado +25 locations
Conditions: Demyelinating Diseases, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Attack, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Optic Neuritis
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Reinventing Yourself With Multiple Sclerosis (MS)
NCT05195320
Recruiting
Given the knowledge that detriments in QOL, well-being, and participation are common in MS and attributable in a large part to individual, person-specific factors (e.g., self-efficacy), efforts to develop interventions aimed at addressing these factors is well needed and likely to have a significant impact. The proposed investigation will consist of two phases involving participant recruitment and data collection. Phase 1 will consist of a focus group aimed at identifying the unique needs of ind... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/12/2022
Locations: Kessler Foundation, East Hanover, New Jersey
Conditions: Multiple Sclerosis
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High Intensity Interval Gait Training in Multiple Sclerosis
NCT05560880
Recruiting
Over 90% of persons with MS (pwMS) complain of difficulty with walking. High intensity interval gait training (HIIGT), where persons alternate brief periods of walking at high speeds with periods of rest has been found to improve walking in other neurologic diagnoses. However its impact on pwMS is not known. Most gait training in MS is done continuously at a slower pace. The purpose of this study is to compare the effects of HIIGT to traditional Moderate Intensity Continuous Gait Training (MICGT... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/05/2022
Locations: Hunter College, New York, New York
Conditions: Multiple Sclerosis
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Genes and Environment in Multiple Sclerosis
NCT01353547
Recruiting
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS wil... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/16/2022
Locations: National Institute of Neurological Disorders and Stroke, Bethesda, Maryland +4 locations
Conditions: Multiple Sclerosis
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Telehealth Pain Self-Management for Employed Adults
NCT04248725
Recruiting
The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed. Participants from anywhere in the US will be randomized to either E-TIPS, a cognitive-behavioral pain self-management intervention delivered by telephone, or a waitlist control. Outcomes, including pain interference, will be assessed at baseline, mid-treatment, post-treatment, and 6-month foll... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2022
Locations: University of Washington, Seattle, Washington
Conditions: Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries, Amputation
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IL-11 in the Development of Multiple Sclerosis
NCT03735823
Recruiting
Since the last submission, the investigator have further characterized the potential of IL--11 to induce encephalitogenic CD4+IL--17A+, IL--21+ and GM--CSF+ cells, which upon passive transfer induced severe RREAE with IL--17A+CCR6+ CD4+ cell, neutrophil, CD8+ and B--cell accumulation within the CNS (manuscript submitted for publication). These findings confirmed our hypothesis and further characterization of the IL--11--induced encephalitogenic CD4+ cells will be performed as planned in the gran... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
06/03/2022
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Multiple Sclerosis
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