There are currently 127 active clinical trials seeking participants for Multiple Sclerosis research studies. The states with the highest number of trials for Autism participants are New York, Florida, California and Ohio.
ETNA-MS Device Validation Study
NCT06256731
Recruiting
The overarching goal of this research protocol is to validate the effectiveness of Innodem's ETNA-MS device in informing clinicians on the disability status of Multiple Sclerosis (MS) patients. Effectiveness of the device will be assessed by the level of agreement between the EDSS estimated by the device and the actual scores measured by the neurologist in-person assessments.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: MS Integrated Center, Phoenix, Arizona +4 locations
Conditions: Multiple Sclerosis
Register for Updates
PET Imaging of Cyclooxygenase-2 in Multiple Sclerosis
NCT05062083
Recruiting
Background: Multiple sclerosis (MS) is an autoimmune disease that has no cure. MRI is the main tool used in the study and treatment of people with MS. A tracer has been developed for cyclooxygenase-2 (COX-2), an enzyme found in the brain during inflammation. Researchers want to explore the role inflammation plays in MS and see if COX-2 is measurable in the brains of people with the disease. Objective: To see if COX-2 is detectable in the brains of individuals with MS. Eligibility: People ag... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
01/30/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Multiple Sclerosis
Register for Updates
Retinal Imaging in Neurodegenerative Disease
NCT03233646
Recruiting
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Mild Cognitive Impairment, Multiple Sclerosis, Huntington Disease, Neuro-Degenerative Disease, Alzheimer's Disease, Parkinson's Disease, Lewy Body Dementia, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis (ALS), APOE-4 Positive, Traumatic Brain Injury, Concussion, Post-Traumatic Stress Disorder, Down Syndrome, Normal Cognition
Register for Updates
WOE of Anti-CD20 Therapies
NCT06121349
Recruiting
The nature, intensity, and prevalence of this wearing-off effect remain poorly understood. To our knowledge, there is no consensus in the literature on what symptoms constitute a wearing-off effect, nor is there a single validated scale that measures wearing-off effect. The current study will explore the wearing-off effect associated with OCR and OMB, using a variety of validated scales assessing MS symptoms (i.e., fatigue, mobility, pain, depression, cognition), as well as some global questions... Read More
Gender:
All
Ages:
Between 21 years and 85 years
Trial Updated:
01/26/2024
Locations: Novartis Investigational site, East Hanover, New Jersey
Conditions: Multiple Sclerosis
Register for Updates
Wearables for the Bladder: an In-home Treatment Feasibility Pilot Study
NCT05715268
Recruiting
The goal is to investigate the feasibility and effects of adding "wearables for the bladder" devices to conventional pelvic floor physical therapy (PFPT) to bladder function, in people with multiple sclerosis (MS).
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2024
Locations: University of California San Francisco, Weill Institute for Neurosciences, San Francisco, California
Conditions: Multiple Sclerosis, Urinary Bladder, Overactive
Register for Updates
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
NCT04603196
Recruiting
This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which is likely detrimental to MS. Clinical data (MRI, lab results, medical history, labs, and sleep studies) of MS patients will be collected and analyzed. This will be done to study correlations between MRI, clinical data, lab studies and sleep studies. There is specific interest in the type of sleep apnea associated with MS, and whether MRI... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Multiple Sclerosis, Obstructive Sleep Apnea
Register for Updates
Epidural Stimulation in Multiple Sclerosis
NCT06019611
Recruiting
A study to quantify changes in motor performance of epidural stimulation in progressive multiple sclerosis (MS) patients over the course of 12 rehabilitation sessions.
Gender:
All
Ages:
22 years and above
Trial Updated:
01/16/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Multiple Sclerosis, Demyelinating Disorder, Autoimmune Diseases
Register for Updates
A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition
NCT05781113
Recruiting
To measure the effectiveness of a Remote Patient Monitoring solution based on the use of a smart insole wearable device (and associated smart phone app), for monitoring MS patients' condition on a day-to-day basis. The main focus is the objective measurement of gait, given that 75% of people with MS display clinically significant gait impairments. Initial gait lab "gold standard" data indicate that the Artificial Intelligence (AI)-based digital biomarker will prove to be highly effective at dete... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
01/12/2024
Locations: Brigham and Women's Hospital, Boston, Massachusetts +2 locations
Conditions: Multiple Sclerosis
Register for Updates
Examining the Effects of a Remotely-delivered, Racially-tailored Exercise Training Program for Immediate and Sustained Improvements in Walking Dysfunction, Symptoms, and Health-related Quality of Life (HRQOL) Among African-Americans With Multiple Sclerosis (MS) Residing in Rural Environments.
NCT05516537
Recruiting
The proposed project involves a high-quality randomized controlled (RCT) design that examines the effects of a remotely-delivered, racially-tailored exercise training program for immediate and sustained improvement in walking dysfunction, symptoms, and health-related quality of life (HRQOL) among African-Americans with MS residing in rural environments. The primary analysis will test the hypothesis that those who are randomly assigned into the intervention condition (i.e., exercise training) wil... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/10/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Multiple Sclerosis
Register for Updates
Identifying and Characterizing Preclinical MS
NCT05787795
Recruiting
The purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/04/2024
Locations: Yale University, North Haven, Connecticut
Conditions: Multiple Sclerosis
Register for Updates
Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
NCT02994121
Recruiting
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Gender:
All
Ages:
7 years and above
Trial Updated:
01/03/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Multiple Sclerosis
Register for Updates
Cognitive Markers in Prodromal MS
NCT05543915
Recruiting
The focus of this work is the evaluation of a measure of cognitive functioning- intra-individual variability (IIV) - derived from a computer-based continuous reaction time (RT) task (Cogstate) as an early marker of prodromal MS.
Gender:
All
Ages:
Between 23 years and 59 years
Trial Updated:
01/02/2024
Locations: NYU Langone Health, New York, New York
Conditions: Multiple Sclerosis
Register for Updates