There are currently 116 active clinical trials seeking participants for Multiple Sclerosis research studies. The states with the highest number of trials for Multiple Sclerosis participants are Florida, New York, California and Ohio.
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS)
NCT06145737
Recruiting
The goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with multiple sclerosis (MS). The main questions it aims to answer are: 1. Can the current HOBSCOTCH program be adapted for people with MS? 2. Will people with MS experience improved quality of life similar to that found in people with epilepsy after participating in the HOBSCOTCH program? Participants will be asked to: * at... Read More
Gender:
ALL
Ages:
Between 20 years and 65 years
Trial Updated:
01/07/2025
Locations: Dartmouth-Hitchcock, Lebanon, New Hampshire
Conditions: Multiple Sclerosis, Cognitive Dysfunction, Memory Disorders
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Entire-body PET Scans for Multiple Sclerosis
NCT04390009
Recruiting
To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.
Gender:
ALL
Ages:
Between 25 years and 55 years
Trial Updated:
01/04/2025
Locations: Brain Health Alliance, Ladera Ranch, California
Conditions: Multiple Sclerosis
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Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
NCT02994121
Recruiting
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Gender:
ALL
Ages:
7 years and above
Trial Updated:
01/01/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Multiple Sclerosis
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Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
NCT06136728
Recruiting
The goal of this clinical trial is to evaluate if combining a medication that can help improve walking in people with multiple sclerosis (MS) with a physical therapy program is better for improving walking than either treatment alone. The main questions this study will answer are: * Does combining dalfampridine with physical therapy improve mobility more than physical therapy without concurrent dalfampridine? * Is the combined treatment associated with better outcomes than the medication (dalfa... Read More
Gender:
ALL
Ages:
Between 25 years and 75 years
Trial Updated:
12/16/2024
Locations: MGH Institute of Health Professions, Boston, Massachusetts
Conditions: Multiple Sclerosis
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Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
NCT03759522
Recruiting
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-in... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/13/2024
Locations: University of Alabama at Birmingham Medical Center, Birmingham, Alabama
Conditions: Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
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Reducing Fatigue in People With Multiple Sclerosis by Treatment With TENS
NCT05500963
Recruiting
The objective of the randomized, sham-controlled trial will be to evaluate the effectiveness of treatment with transcutaneous electrical nerve stimulation (TENS) at reducing the level of fatigue experienced by people with MS.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2024
Locations: University of Colorado, Boulder, Colorado
Conditions: Multiple Sclerosis
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MS-DETECT: Early Detection of Multiple Sclerosis Progression with MSCopilot® Detect
NCT05816122
Recruiting
The study aims to evaluate MSCopilot® Detect, a smartphone application for at-home monitoring of patients with Multiple Sclerosis (MS). The primary objective is to enhance and standardize remote monitoring of MS patients to accurately assess disease progression caused by either Relapse Activity Worsening (RAW) or Progression Independent of Relapses (PIRA). The study also aims to assess the safety, usability, and satisfaction of the solution. A secondary objective is to determine MSCopilot® Det... Read More
Gender:
ALL
Ages:
Between 30 years and 65 years
Trial Updated:
12/04/2024
Locations: Jennifer Graves, San Diego, California +35 locations
Conditions: Multiple Sclerosis
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Obesity and Pediatric Multiple Sclerosis
NCT04593082
Recruiting
Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental i... Read More
Gender:
ALL
Ages:
Between 10 years and 20 years
Trial Updated:
12/03/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Multiple Sclerosis
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Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis
NCT05285891
Recruiting
This study is a prospective, multi-center, randomized, double blinded, placebo-controlled study of OCR treatment-discontinuation in patients with early RMS. All eligible participants will be initiated on OCR using the standard approved administration schedule of two 300 mg infusions separated by 14 days (i.e., Days 0 and 14) for a total of 600 mg, followed by 600 mg infusions at Month 6,12, 18, and 24. At Month 24, participants will be randomized (2:1) to one of two Arms with randomized treatmen... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
12/03/2024
Locations: Yale School of Medicine, New Haven, Connecticut +10 locations
Conditions: Multiple Sclerosis
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Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis
NCT04518657
Recruiting
We propose a highly-informed, well-designed randomized controlled trial (RCT) that is critical for providing Class I evidence regarding an Internet-delivered physical activity (PA) intervention as a behavioral approach for managing slowed cognitive processing speed (CPS; the most common and perhaps most burdensome MS-related cognitive impairment) and its second learning and memory, symptomatic, and quality of life (QOL) correlates among fully-ambulatory persons with multiple sclerosis (MS) who p... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/11/2024
Locations: University of Illinois at Chicago, Chicago, Illinois
Conditions: Multiple Sclerosis
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NARCOMS Registry: a Multiple Sclerosis Registry
NCT01018537
Recruiting
This project is based on the idea that we can learn about the complexities of MS by following disease and treatment patterns in a large group of people over several years. The information gathered is used for research only. Results are presented in summary form only. All details submitted by registry participants is strictly confidential. To participate in NARCOMS complete the baseline enrollment survey online through www.narcoms.org (or directly using the following link: https://redcap.link/py... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/11/2024
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Multiple Sclerosis
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Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.
NCT03807973
Recruiting
This study will use brain Positron Emission Tomography/ Magnetic Resonance Imaging (PET/MRI) and an investigational radioactive drug called \[Zr-89\]oxine to track the location of white blood cells (also called leukocytes) in the body. PET/MRI will be used to visualize labeled white blood cells and determine if they enter the central nervous system in conditions associated with brain inflammation (also called neuroinflammation). By better understanding the role of neuroinflammation in fibromyalg... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/01/2024
Locations: UAB, Birmingham, Alabama
Conditions: Fibromyalgia, Chronic Fatigue Syndrome, Multiple Sclerosis, Healthy
Register for Updates