There are currently 42 active clinical trials seeking participants for Parkinson's Disease research studies. The states with the highest number of trials for Autism participants are Florida, California, New York and Texas.
Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease
Recruiting
Parkinson's disease (PD) is a difficult to treat condition that impairs mobility and thinking. It is not fully treated by drugs and surgery. Two priority issues for most people with PD are "OFF-time" and Cognitive impairment. Even under best medical management, 74% of people with PD experience "OFF-time," which is when medications are just not working right. OFF-time severely impacts both quality of life and thinking. Cognitive problems are found even in newly diagnosed people with PD and are ve... Read More
Gender:
All
Ages:
Between 40 years and 89 years
Trial Updated:
01/24/2024
Locations: Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia
Conditions: Parkinson's Disease, Exercise Therapy, Cognition
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
Recruiting
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic Percept PC DBS device. The investigators hypothesize that stimulation patterns designed to better target excessive synchrony in a patient-tailored manner may result in more efficient and effective therapy with fewer side effects. Medtronic 3rd-generation sensing implantable... Read More
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
01/10/2024
Locations: Unversity of Nebraska Medical Center, Omaha, Nebraska
Conditions: Parkinson's Disease
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
Recruiting
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practi... Read More
Gender:
All
Ages:
Between 21 years and 89 years
Trial Updated:
01/08/2024
Locations: University Of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson's Disease
Genotypic Influences on Network Progression in Parkinson's Disease
Recruiting
In this longitudinal study, the investigators will follow Parkinson's disease (PD) patients with and without glucocerebrosidase (GBA) mutations. The investigators hypothesize that the rate of increase in brain network activity over time (network progression rate) is faster in patients with GBA gene mutations.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
01/02/2024
Locations: Feinstein Institutes for Medical Research, Manhasset, New York
Conditions: Parkinson's Disease
PET Imaging Evaluation of [11C]SY08
Recruiting
The overall goal of the proposed research is to evaluate the use of [11C]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Parkinson's disease (PD), Multiple system atrophy (MSA), Dementia with Lewy Bodies (DLB) and healthy controls. The purpose of this study is to evaluate the use of [11C]SY08 as a PET radiotracer for αS fibrils in individuals with PD, MSA, DLB and healthy controls. The specific aims of the current study are: To determine brain uptake, distribu... Read More
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
12/29/2023
Locations: MGH, Charlestown, Massachusetts
Conditions: Parkinson's Disease, Multiple System Atrophy, Dementia With Lewy Bodies, Healthy Controls
Telemedicine Intervention in Patients With Chronic Pain in PD
Recruiting
Pain is a very common and disabling symptom in Parkinson's disease, yet it is often untreated. This study will assess the impact of home-based physical and cognitive exercise interventions to reduce pain in this disease. This approach would offer an easily implemented and affordable way to encourage and maintain use of these interventions by patients virtually indefinitely through remote access technology. The study findings may help VA clinicians provide optimal care for the many Veterans with... Read More
Gender:
All
Ages:
Between 40 years and 89 years
Trial Updated:
12/22/2023
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Parkinson's Disease
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB094 in Adults With Parkinson's Disease
Recruiting
The primary objective of this study is to evaluate the safety and tolerability of single and multiple doses of BIIB094 administered via intrathecal (IT) injection to participants with Parkinson's Disease (PD). The secondary objective of this study is to evaluate the pharmacokinetic (PK) profile of BIIB094.The study is open for PD patients with verified presence or absence of variations in the leucine-rich repeated kinase 2 (LRRK2) gene, but also for patients without any verified PD-related genet... Read More
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
12/20/2023
Locations: Northwestern University PD and Movement Disorders Center, Chicago, Illinois +17 locations
Conditions: Parkinson's Disease
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
Recruiting
The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and biochemical parameters.
Gender:
All
Ages:
Between 35 years and 75 years
Trial Updated:
12/11/2023
Locations: University of California Irvine, Irvine, California +10 locations
Conditions: Parkinson's Disease, Multiple System Atrophy, Parkinson Variant, Multiple System Atrophy
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
Recruiting
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who have a pathogenic variant in the glucocerebrosidase 1 (GBA1) gene (GBA-PD).
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
11/22/2023
Locations: Barrow Neurological Institute, Phoenix, Arizona +74 locations
Conditions: Parkinson's Disease
Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia Nigra (GUIDE)
Recruiting
This is an open-label, non-randomized, single-arm trial design to actively follow participants for 12 months. Ten participants will be enrolled to receive bilateral delivery of Peripheral Nerve Tissue (PNT) to the Substantia Nigra at the time of Deep Brain Stimulation (DBS) surgery. After 12 months, participants will be followed long term through annual visits for the rest of their lives. Participants will serve as their own donor for the tissue.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
11/10/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Parkinson's Disease
Effect of Osteopathic Manipulative Medicine on Constipation in Parkinson's Disease
Recruiting
The aim of this pilot study is to investigate the effect of Osteopathic Manipulative Medicine (OMM) in decreasing constipation symptoms in people with Parkinson's disease (PD). A second but optional aim is to determine if OMM changes the bacterial flora of the mouth and gut. OMM is a safe and gentle manual treatment provided by osteopathic physicians. All participants will receive OMM during the second half of the eleven week trial.
Gender:
All
Ages:
40 years and above
Trial Updated:
11/08/2023
Locations: New York Institute of Technology- Academic Health Care Center, Old Westbury, New York
Conditions: Parkinson's Disease, Constipation
Remote Dynamic Cycling for the Customized Off-site Rehab in Parkinson's Disease
Recruiting
This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson's disease. The investigators will examine the efficacy of novel rehab technique that can be monitored and modified in real-time but over virtual interface using a remotely located device in a paradigm called dynamic cycling. This technology will benefit thousands of Veterans who need customized and cost-effective... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/02/2023
Locations: Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
Conditions: Parkinson's Disease