There are currently 40 active clinical trials seeking participants for Parkinson's Disease research studies. The states with the highest number of trials for Parkinson's Disease participants are Florida, California, New York and Texas.
Sensory-specific Peripheral Stimulation for Tremor Management
NCT04501133
Recruiting
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons. For this purpose, the investigators will use transcutaneous PES, high-density electromyography (HD-EMG), transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and neuromusculoskeletal modelling. This study will be carried out in both healthy participants and patients... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/01/2024
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Parkinson's Disease, Essential Tremor
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Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
NCT04799470
Recruiting
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic Percept PC DBS device. The investigators hypothesize that stimulation patterns designed to better target excessive synchrony in a patient-tailored manner may result in more efficient and effective therapy with fewer side effects. Medtronic 3rd-generation sensing implantable... Read More
Gender:
ALL
Ages:
Between 19 years and 80 years
Trial Updated:
07/26/2024
Locations: Unversity of Nebraska Medical Center, Omaha, Nebraska
Conditions: Parkinson's Disease
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Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
NCT05070013
Recruiting
This study is aimed at testing the hypothesis that adaptive stimulation of the Subthalamic Nucleus (STN) drives changes in sleep episode maintenance and improves sleep quality. Investigators will directly test the efficacy of an adaptive stimulation protocol. Study subjects are adults with Parkinson's disease who experience inadequate motor symptom relief, and who have been offered implantation of a deep brain stimulator system targeting STN for the treatment of motor symptoms (standard-of-care)... Read More
Gender:
ALL
Ages:
Between 19 years and 80 years
Trial Updated:
07/26/2024
Locations: University of Nebraska Medical Center, Omaha, Nebraska +1 locations
Conditions: Parkinson's Disease, Sleep Fragmentation
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Patterned Multichannel Vibrotactile Stimulation for the Longitudinal Treatment of Moderate Stage Parkinson's Disease
NCT05830110
Recruiting
The purpose of the present research is to examine the effectiveness of a non-invasive, vibrotactile stimulation protocol, known as coordinated reset (CR), for the alleviation of motor symptoms in patients with Parkinson's disease (PD). PD patients exhibit rigidity, slowness (bradykinesia) and poverty (akinesia) of movement as well as other symptoms. Treatment for PD is either pharmacological (first line) or invasive deep brain stimulation. The non-invasive, vibrotactile stimulation approach uses... Read More
Gender:
ALL
Ages:
Between 45 years and 90 years
Trial Updated:
07/23/2024
Locations: Synergic Medical Technologies, Eugene, Oregon
Conditions: Parkinson's Disease
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Parkinson's Foundation PD GENEration Genetic Registry
NCT04994015
Recruiting
Development of a central repository for PD-related genomic data for future research.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: MD First Research, Chandler, Arizona +47 locations
Conditions: Parkinson's Disease
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Parkinson's Disease in Asian Americans
NCT05532982
Recruiting
The ultimate goal of this project is to use the findings to develop culturally appropriate programs and resources that can be disseminated to key stakeholders to improve access to PD care and increase inclusivity in PD research for Asian Americans. This study will serve as a first step towards developing broader community and patient education programs and active outreach campaigns to increase PD-specific literacy among Asian Americans. The results from this study will elucidate the role that la... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2024
Locations: Tufts University School of Medicine, Boston, Massachusetts
Conditions: Parkinson's Disease
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The Parkinson's Genetic Research Study
NCT01558479
Recruiting
The Parkinson's Genetic Research Study (PaGeR), headed by Dr. Cyrus Zabetian, is searching for genes that increase the risk of developing Parkinson's disease (PD) and related disorders. The study is a joint effort by neurologists and researchers across the United States and is sponsored by the National Institutes of Health. The coordinating center for PaGeR is located at the University of Washington and the VA Puget Sound Health Care System in Seattle.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2024
Locations: Emory University/ Wesley Woods Health Center, Atlanta, Georgia +4 locations
Conditions: Parkinson's Disease
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The Motor Network in Essential Tremor: Mechanisms of Therapy
NCT02712515
Recruiting
Essential tremor (ET) is among the most common movement disorders, and is the most prevalent tremor disorder. It is a progressive, degenerative brain disorder that results in increasingly debilitating tremor, and afflicts an estimated 7 million people in the US (2.2% of the population) and estimates from population studies worldwide range from 0.4% to 6.3%. ET is directly linked to progressive functional impairment, social embarrassment, and even depression. Intention (kinetic) tremor of the arm... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
04/23/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Essential Tremor, Parkinson's Disease
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Vestibulopathy as a Cause of Imbalance in Parkinson
NCT04768647
Recruiting
Balance problems and falls are common in people with Parkinson's disease but respond poorly to dopamine stimulating medications suggesting other causes. The main goal of this study is to assess whether imbalance and gait problems in people with Parkinson's disease may be related to vestibular (inner ear balance center) changes not related to loss of dopamine in the brain.
Gender:
All
Ages:
45 years and above
Trial Updated:
04/22/2024
Locations: VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan +1 locations
Conditions: Parkinson's Disease
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At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
NCT01931644
Recruiting
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research. We make it easy for patients to contribute to research for medical conditions that matter most to them, regardless of their location or ability to travel.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
04/15/2024
Locations: Sanguine Biosciences, Los Angeles, California
Conditions: All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis, Asthma, Atopic Dermatitis Eczema, Beta Thalassemia, Bipolar Disorder, Breast Cancer, Celiac Disease, Cervical Cancer, Chronic Inflammatory Demyelinating Polyneuropathy, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease, Colon Cancer, Colorectal Cancer, Crohn's Disease, Cystic Fibrosis, Depression, Diabetes Mellitus, Duchenne Muscular Dystrophy, Endometriosis, Epilepsy, Facioscapulohumeral Muscular Dystrophy, G6PD Deficiency, General Anxiety Disorder, Hepatitis B, Hereditary Hemorrhagic Telangiectasia, HIV/AIDS, Human Papilloma Virus, Huntington's Disease, Idiopathic Thrombocytopenic Purpura, Insomnia, Kidney Cancer, Leukemia, Lung Cancer, Lupus Nephritis, Lymphoma, Melanoma, Multiple Myeloma, Multiple Sclerosis, Myositis, Myotonic Dystrophy, Ovarian Cancer, Pancreatic Cancer, Parkinson's Disease, Polycystic Kidney Diseases, Prostate Cancer, Psoriasis, Psoriatic Arthritis, Rosacea, Scleroderma, Sickle Cell Anemia, Sickle Cell Trait, Sjogren's Syndrome, Skin Cancer, Spinal Muscular Atrophy, Systemic Lupus Erythematosus, Thrombotic Thrombocytopenic Purpura, Trisomy 21, Ulcerative Colitis
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Combining Aerobic Exercise and Virtual Reality for Cognitive-motor Rehabilitation in PD
NCT05385497
Recruiting
This project will provide preliminary data on the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD. Results from this work will provide insight into whether combination interventions utilizing AE and VR have parallel effects on cognition, gait, and neuroplasticity in PD.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/10/2024
Locations: UT Health San Antonio- Dept. of Physical Therapy, San Antonio, Texas
Conditions: Parkinson's Disease
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Gait Analysis in Neurological Disease
NCT02994719
Recruiting
The purpose of this study is to investigate whether speed-dependent measures of gait can be identified in patients with neurological conditions that affect gait, particularly in subjects with parkinsonian disorders.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/02/2024
Locations: Clinical Research Center BIDMC, Boston, Massachusetts
Conditions: Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration, Gait, Frontal, Huntington Disease
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