There are currently 42 active clinical trials seeking participants for Parkinson's Disease research studies. The states with the highest number of trials for Autism participants are Florida, California, New York and Texas.
Partnered Dance Aerobic Exercise as a Neuroprotective, Motor and Cognitive Intervention in Parkinson's Disease
NCT04122690
Recruiting
Parkinson's disease (PD) is a difficult to treat condition that impairs mobility and thinking. It is not fully treated by drugs and surgery. Two priority issues for most people with PD are "OFF-time" and Cognitive impairment. Even under best medical management, 74% of people with PD experience "OFF-time," which is when medications are just not working right. OFF-time severely impacts both quality of life and thinking. Cognitive problems are found even in newly diagnosed people with PD and are ve... Read More
Gender:
All
Ages:
Between 40 years and 89 years
Trial Updated:
01/24/2024
Locations: Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia
Conditions: Parkinson's Disease, Exercise Therapy, Cognition
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Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
NCT04799470
Recruiting
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic Percept PC DBS device. The investigators hypothesize that stimulation patterns designed to better target excessive synchrony in a patient-tailored manner may result in more efficient and effective therapy with fewer side effects. Medtronic 3rd-generation sensing implantable... Read More
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
01/10/2024
Locations: Unversity of Nebraska Medical Center, Omaha, Nebraska
Conditions: Parkinson's Disease
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Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
NCT05557864
Recruiting
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practi... Read More
Gender:
All
Ages:
Between 21 years and 89 years
Trial Updated:
01/08/2024
Locations: University Of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson's Disease
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Genotypic Influences on Network Progression in Parkinson's Disease
NCT04228172
Recruiting
In this longitudinal study, the investigators will follow Parkinson's disease (PD) patients with and without glucocerebrosidase (GBA) mutations. The investigators hypothesize that the rate of increase in brain network activity over time (network progression rate) is faster in patients with GBA gene mutations.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
01/02/2024
Locations: Feinstein Institutes for Medical Research, Manhasset, New York
Conditions: Parkinson's Disease
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Telemedicine Intervention in Patients With Chronic Pain in PD
NCT05410392
Recruiting
Pain is a very common and disabling symptom in Parkinson's disease, yet it is often untreated. This study will assess the impact of home-based physical and cognitive exercise interventions to reduce pain in this disease. This approach would offer an easily implemented and affordable way to encourage and maintain use of these interventions by patients virtually indefinitely through remote access technology. The study findings may help VA clinicians provide optimal care for the many Veterans with... Read More
Gender:
All
Ages:
Between 40 years and 89 years
Trial Updated:
12/22/2023
Locations: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts
Conditions: Parkinson's Disease
Register for Updates
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
NCT05699460
Recruiting
The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and biochemical parameters.
Gender:
All
Ages:
Between 35 years and 75 years
Trial Updated:
12/11/2023
Locations: University of California Irvine, Irvine, California +10 locations
Conditions: Parkinson's Disease, Multiple System Atrophy, Parkinson Variant, Multiple System Atrophy
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Feasibility and Safety of autoloGous UncondItioneD pEripheral Nerve Tissue Delivery to the Substantia Nigra (GUIDE)
NCT05377281
Recruiting
This is an open-label, non-randomized, single-arm trial design to actively follow participants for 12 months. Ten participants will be enrolled to receive bilateral delivery of Peripheral Nerve Tissue (PNT) to the Substantia Nigra at the time of Deep Brain Stimulation (DBS) surgery. After 12 months, participants will be followed long term through annual visits for the rest of their lives. Participants will serve as their own donor for the tissue.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
11/10/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Parkinson's Disease
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Effect of Osteopathic Manipulative Medicine on Constipation in Parkinson's Disease
NCT02344485
Recruiting
The aim of this pilot study is to investigate the effect of Osteopathic Manipulative Medicine (OMM) in decreasing constipation symptoms in people with Parkinson's disease (PD). A second but optional aim is to determine if OMM changes the bacterial flora of the mouth and gut. OMM is a safe and gentle manual treatment provided by osteopathic physicians. All participants will receive OMM during the second half of the eleven week trial.
Gender:
All
Ages:
40 years and above
Trial Updated:
11/08/2023
Locations: New York Institute of Technology- Academic Health Care Center, Old Westbury, New York
Conditions: Parkinson's Disease, Constipation
Register for Updates
rTMS to Improve Cognition in Parkinson's
NCT03836950
Recruiting
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease who are experiencing mild problems with their thinking ability.
Gender:
All
Ages:
50 years and above
Trial Updated:
11/02/2023
Locations: Jesse Brown VA Medical Center, Chicago, IL, Chicago, Illinois +1 locations
Conditions: Parkinson's Disease, Mild Cognitive Impairment
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Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
NCT05070013
Recruiting
This study is aimed at testing the hypothesis that adaptive stimulation of the Subthalamic Nucleus (STN) drives changes in sleep episode maintenance and improves sleep quality. Investigators will directly test the efficacy of an adaptive stimulation protocol. Study subjects are adults with Parkinson's disease who experience inadequate motor symptom relief, and who have been offered implantation of a deep brain stimulator system targeting STN for the treatment of motor symptoms (standard-of-care)... Read More
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
10/19/2023
Locations: University of Nebraska Medical Center, Omaha, Nebraska +1 locations
Conditions: Parkinson's Disease, Sleep Fragmentation
Register for Updates
Sensory-specific Peripheral Stimulation for Tremor Management
NCT04501133
Recruiting
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons. For this purpose, the investigators will use transcutaneous PES, high-density electromyography (HD-EMG), transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and neuromusculoskeletal modelling. This study will be carried out in both healthy participants and patients... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/04/2023
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Parkinson's Disease, Essential Tremor
Register for Updates
Noninterventional Study Evaluating Parkinson's Disease Diary Use
NCT05363046
Recruiting
This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide adequate control of symptoms.
Gender:
All
Ages:
Between 39 years and 70 years
Trial Updated:
09/12/2023
Locations: Mayo Clinic Neurology, Scottsdale, Arizona +33 locations
Conditions: Parkinson's Disease
Register for Updates