There are currently 44 active clinical trials seeking participants for Parkinson's Disease research studies. The states with the highest number of trials for Parkinson's Disease participants are Florida, California, New York and Texas.
rTMS to Improve Cognition in Parkinson's
NCT03836950
Recruiting
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease who are experiencing mild problems with their thinking ability.
Gender:
All
Ages:
50 years and above
Trial Updated:
11/02/2023
Locations: Jesse Brown VA Medical Center, Chicago, IL, Chicago, Illinois +1 locations
Conditions: Parkinson's Disease, Mild Cognitive Impairment
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Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
NCT05070013
Recruiting
This study is aimed at testing the hypothesis that adaptive stimulation of the Subthalamic Nucleus (STN) drives changes in sleep episode maintenance and improves sleep quality. Investigators will directly test the efficacy of an adaptive stimulation protocol. Study subjects are adults with Parkinson's disease who experience inadequate motor symptom relief, and who have been offered implantation of a deep brain stimulator system targeting STN for the treatment of motor symptoms (standard-of-care)... Read More
Gender:
All
Ages:
Between 19 years and 80 years
Trial Updated:
10/19/2023
Locations: University of Nebraska Medical Center, Omaha, Nebraska +1 locations
Conditions: Parkinson's Disease, Sleep Fragmentation
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Sensory-specific Peripheral Stimulation for Tremor Management
NCT04501133
Recruiting
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons. For this purpose, the investigators will use transcutaneous PES, high-density electromyography (HD-EMG), transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and neuromusculoskeletal modelling. This study will be carried out in both healthy participants and patients... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
10/04/2023
Locations: Shirley Ryan AbilityLab, Chicago, Illinois
Conditions: Parkinson's Disease, Essential Tremor
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Noninterventional Study Evaluating Parkinson's Disease Diary Use
NCT05363046
Recruiting
This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide adequate control of symptoms.
Gender:
All
Ages:
Between 39 years and 70 years
Trial Updated:
09/12/2023
Locations: Mayo Clinic Neurology, Scottsdale, Arizona +33 locations
Conditions: Parkinson's Disease
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Physiological Brain Atlas Development
NCT00575081
Recruiting
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Gender:
All
Ages:
Between 6 years and 90 years
Trial Updated:
08/09/2023
Locations: Vanderbilt Univeristy, Nashville, Tennessee
Conditions: Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor, Epilepsy
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Perception in Parkinson's Disease
NCT05483036
Recruiting
The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to pa... Read More
Gender:
All
Ages:
Between 40 years and 110 years
Trial Updated:
05/24/2023
Locations: Vision and Cognition Laboratory, Boston University, Boston, Massachusetts
Conditions: Parkinson's Disease, Visual Hallucination, Perception
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Imaging a Cholinergic Biomarker of Cognition in Parkinson's Disease
NCT05034263
Recruiting
This is an imaging study designed to illuminate the function of the cholinergic system and its association with cognitive skills in people with Parkinson's disease. The hypothesis of this study is that there will be an association between cholinergic terminal density, sex hormones, and cognitive functioning. Participants will receive a PET and MRI scan along with a battery of neurocognitive tests at baseline and again at 18 months follow-up. Hormone levels will be measured at baseline.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
10/24/2022
Locations: Stony Brook Medical Center, Stony Brook, New York
Conditions: Parkinson's Disease
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Modifiable Variables in Parkinsonism (MVP)
NCT02194816
Recruiting
We are trying to identify factors associated with improved quality of life and fewer PD symptoms. We are attempting to identify practices, beliefs, and therapies used by individuals who report excellent quality of life, few PD symptoms, and reduced rates of progression. After agreeing to participate, we will ask participants to fill our questionnaires about their experience with PD, their health in general, along with their food intake every six months for five years.
Gender:
All
Ages:
19 years and above
Trial Updated:
03/10/2022
Locations: Bastyr University, Kenmore, Washington
Conditions: Parkinson's Disease, Parkinsonism, MSA - Multiple System Atrophy, Progressive Supranuclear Palsy, Shy-Drager Syndrome, Corticobasal Degeneration, Dementia With Lewy Bodies, Pick Disease, Olivopontocerebellar Atrophies
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