Connecticut is currently home to 1245 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of Circulating Monocytes in Patients With Ischemic Vascular Disease
NCT04321512
Recruiting
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries. The r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Myocardial Infarction, Stroke, Ischemic, Ischemia
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Circulating Markers for Ischemic Heart Disease
NCT00762333
Recruiting
The purpose of this research is to determine if two proteins in the blood are increased during acute myocardial infarction and whether their levels are higher in those who develop heart failure than those who do not. These two proteins are produced and potentially released when the heart muscle is damaged. They may then be released into the blood and be detected by standard method in the research laboratory. At this time, detection of an increase in these proteins in the blood is not known to be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Myocardial Infarction, Ischemia, Congestive Heart Failure
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Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
NCT00762008
Recruiting
The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Acute Decompensated Heart Failure, Heart Failure
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Characterizing Orthodontic Tooth Movement With Photographic Scans
NCT05780788
Recruiting
Characterizing orthodontic tooth movements in real time by using photographic scans to monitor teeth movement. The photographic scans will also be compared to 3D model scans. Canine retraction over the course of 1 orthodontic visit will be measured.
Gender:
ALL
Ages:
11 years and above
Trial Updated:
11/27/2023
Locations: UConn Health, Farmington, Connecticut
Conditions: Canine Retraction
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Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)
NCT04321759
Recruiting
To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service cente... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/13/2023
Locations: Hartford Hospital - Institute of Living, Hartford, Connecticut
Conditions: Schizophrenia and Related Disorders
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Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
NCT05042102
Recruiting
The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/07/2023
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Alcohol Use Disorder
Register for Updates
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
NCT01730781
Recruiting
The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis. The investigators will image brain cannabinoid receptors using Positron Emission Tomography (PET) imaging and the radioligand OMAR, in healthy individuals and several conditions including 1) cannabis use disorders, 2) psychotic disorders, 3) prodrome of psychotic illness and 4) individuals with... Read More
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
11/02/2023
Locations: Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut
Conditions: Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism, Healthy Control, Opioid-use Disorder, Post Traumatic Stress Disorder
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Prospective, Observational Study of Wellinks Effect on COPD Hospital Readmissions
NCT05330507
Recruiting
This prospective, observational study is designed to investigate clinical outcomes and collect patient feedback on the use of Wellinks, an integrated virtual chronic obstructive pulmonary disease (COPD) management solution, for patients recently discharged from the hospital due to an acute exacerbation of their COPD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2023
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: COPD, Respiratory Tract Disease, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive, Lung Diseases
Register for Updates
Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon
NCT04168866
Recruiting
The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Appendicitis
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Liposomal Bupivacaine/Bupivacaine in RS Blocks vs. Ropivacaine in RS Blocks And Catheters
NCT05972018
Recruiting
The goal of this randomized clinical trial is to compare single shot rectus sheath blocks of liposomal bupivacaine/bupivacaine mixture to bilateral rectus sheath catheters infused with ropivacaine (standard of care at our facility) in patients undergoing vascular surgery with an open mid-abdominal laparotomy incision. This study will examine the difference in the highest, lowest, average, and current pain scores reported at the end of 24-48 postoperative hours using the brief pain inventory-shor... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
10/19/2023
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Aortic Aneurysm, Abdominal, Abdominal Aortic Occlusion, Aortoiliac Occlusive Disease, Aortic Diseases
Register for Updates
Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for at least 14 days and no more than 60 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and imp... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/17/2023
Locations: Vascular Care Connecticut, Darien, Connecticut
Conditions: Iliofemoral; Thrombosis
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Multi-site Study for Evaluation of Clinical Ranges of Whole Blood Clotting Times of Patients on Anticoagulants and Verification of Measurement Precision of Liquid Quality Controls With the Perosphere Technologies' PoC Coagulometer
NCT04868214
Recruiting
The Perosphere Technologies' PoC Coagulometer measures clotting times of fresh whole blood samples. Clotting is initiated by glass surface activation and terminates on optical detection of fibrin assembly, the final step in the coagulation cascade. Since activation occurs at the top of the intrinsic pathway and detection occurs at the bottom of the final common pathway, the Perosphere Technologies' PoC Coagulometer has shown sensitivity to a broad range of drugs and reagents that affect blood cl... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/25/2023
Locations: Perosphere Technologies Inc., Danbury, Connecticut
Conditions: Coagulation
Register for Updates