Connecticut is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
NCT05865535
Recruiting
This open label ascending dose study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of AV-380 in cancer patients with Cachexia. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bind circulating human growth differentiation factor 15 (GDF-15), a cytokine involved in cancer-induced cachexia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Cachexia
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Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
NCT05753059
Recruiting
Randomized placebo-controlled, double-blind, double-dummy, crossover design testing combinations placebo/placebo, bendroflumethiazide/placebo, amiloride/placebo, and bendroflumethiazide/amiloride added to bumetanide.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Heart Failure
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Video-Based Pelvic Floor Muscle Therapy
NCT06689891
Recruiting
This study is a feasibility, pilot trial of remote, video-based pelvic floor muscle therapy (PFMT) for patients with pelvic floor disorders, including pelvic organ prolapse, urinary incontinence and anorectal dysfunction. PFMT has been shown to improve these symptoms in multiple studies.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Pelvic Floor Disorder, Pelvic Floor Muscle Exercise
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The Impact of Music Medicine on Preterm Brain Development and Behavior
NCT06536296
Recruiting
The investigators are conducting a two-site randomized control trial with the aim of defining the impact of music (M) without or with parent voice (MPV) on very preterm infants' acute and cumulative stress, intranetwork connectivity on term brain MRI, and language and other neurodevelopmental outcomes at two years corrected age. This is based on the hypothesis that infants in MPV arm are expected to experience the greatest benefit compared with infants receiving standard care.
Gender:
ALL
Ages:
Between 24 weeks and 30 weeks
Trial Updated:
06/12/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Infant Development, Language Development, Prematurity, Stress
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A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
NCT05929235
Recruiting
The goal of this clinical trial is to study the safety and tolerability in all advanced solid tumors, including advanced urothelial carcinoma. The main question\[s\] it aims to answer are: * Is FX-909 safe and tolerable * What is the right dose level for patients Participants will be asked to take FX-909 daily , in tablet form and record any outcomes from taking the drug. Participants will also be asked to return for multiple site visits for various blood tests and to collect blood and tumor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Advanced Solid Tumors Cancer, Advanced Urothelial Carcinoma, Oral Drug Administration, Open Label
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A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
NCT05131022
Recruiting
This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the safety and anti-cancer activity of NX-5948 in patients with advanced B-cell malignancies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Diffuse Large B Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Waldenstrom Macroglobulinemia (WM), Primary Central Nervous System Lymphoma (PCNSL), Secondary Central Nervous System Lymphoma (SCNSL)
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Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services
NCT04738825
Recruiting
The proposed study will be a 24-week intervention with a 12-month follow-up period to evaluate the impact of contingency management with stepped care to pre-exposure prophylaxis (PrEP) adherence and support services (CoMPASS) to promote HIV prevention among individuals with opioid use disorder who have injected drugs in their lifetime. In parallel, the investigators will conduct an implementation focused process evaluation to inform real-world implementation of CoMPASS. .
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: Recovery Network of Programs, Inc, Bridgeport, Connecticut
Conditions: Opioid-use Disorder, HIV Prevention Program
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Congenital Uterine Anomalies: Identifying Cancer Associations and Genetic and Environmental Factors to Improve Clinical Care
NCT04661072
Recruiting
The purpose of this research study is to learn more about the health outcomes associated with congenital uterine anomalies (CUAs), and the possible environmental and genetic causes of the condition. The researchers plan to investigate whether any cancer associations (with breast, renal, ovarian, vaginal and uterine cancers) exist in females with CUAs. The investigator will also investigate any environmental and genetic factors that may be responsible for causing CUAs.
Gender:
FEMALE
Ages:
13 years and above
Trial Updated:
06/12/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Congenital Uterine Anomaly
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Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)
NCT04355572
Recruiting
This study is a double blind, placebo controlled, randomized trial of study subjects with PCOS and low vitamin D to 2 groups- placebo and vitamin D replacement. Participants and investigators will be blinded to treatment modality until the end of the trial period
Gender:
FEMALE
Ages:
Between 13 years and 21 years
Trial Updated:
06/12/2025
Locations: Yale New Haven Children's Hospital, New Haven, Connecticut
Conditions: Polycystic Ovarian Syndrome in Adolescent Females, Vitamin D Deficiency
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Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse
NCT06609369
Recruiting
The study aims to investigate whether behavioral interventions promote cessation in adult smokers by ameliorating negative emotions and improving self-control and identify the neural markers of these effects.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
06/11/2025
Locations: Connecticut Mental Health Center, New Haven, Connecticut
Conditions: Tobacco Use, Tobacco Cessation, Insomnia
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Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
NCT05808634
Recruiting
The objective of this study is to assess safety and efficacy of BA3182 in Advanced Adenocarcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Advanced Adenocarcinoma
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Pain Care at Home to Amplify Function (Pain CHAMP)
NCT05333341
Recruiting
This project aims to test simultaneously the effectiveness of telemedicine and collaborative management (TCM) vs. TCM plus Cooperative Pain Education and Self-Management (COPES) on patient level outcomes and the impact of site-tailored Implementation Facilitation to work toward long term opioid therapy dose reduction. Pain CHAMP is a patient-level randomized hybrid II effectiveness-implementation trial comparing TCM vs. TCM + COPES on the primary composite outcome of pain interference and OUD/mi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2025
Locations: VA Connecticut HCS, West Haven, Connecticut
Conditions: Opioid Use Disorder, Opioid Misuse, Chronic Pain
Register for Updates