Connecticut is currently home to 1255 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis
NCT04951622
Recruiting
The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with generalized myasthenia gravis (gMG).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Myasthenia Gravis
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High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction
NCT06945835
Recruiting
The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with neurologic disability. Doctor of Physical Therapy (DPT) students administer the HIM High Intensity Exercise Program. A prior study evaluated the feasibility, safety, and efficacy of the HIM High Intensity Exercise Program and found it feasible, safe, and effective for 30 p... Read More
Gender:
ALL
Ages:
Between 8 years and 99 years
Trial Updated:
04/24/2025
Locations: University of Hartford, West Hartford, Connecticut
Conditions: Cerebral Palsy (CP), Stroke, Spinal Cord Injury, Traumatic Brain Injury, Charcot Marie Tooth Disease (CMT), Spina Bifida
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A Study of PHST001 in Advanced Solid Tumors
NCT06840886
Recruiting
PHST001-101 is a multicenter, open-label, Phase 1 study of PHST001 in patients with advanced solid tumors. The study design includes a Dose Escalation Phase and a Dose Expansion Phase, and will enroll patients with advanced relapsed and/or refractory solid tumors. The study's primary object is to evaluate the safety and tolerability of PHST001 and determine the RP2D (Recommended Phase 2 dose) of PHST001.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Advanced Solid Tumors
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An Evaluation of Hip Preservation Outcomes
NCT05746533
Recruiting
The purpose of this study is to assess outcomes of hip preservation surgeries including open and arthroscopic treatment of femoroacetabular impingement (FAI).
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/24/2025
Locations: Yale New Haven Health, New Haven, Connecticut
Conditions: Hip Arthroscopy, Femoroacetabular Impingement
Register for Updates
Promoting Alcohol Treatment Engagement Post-hospitalization
NCT05338151
Recruiting
This study is a 3-arm randomized clinical trial to evaluate the effectiveness of hospital-initiated Alcohol Use Disorder treatment, involving a Brief Negotiated Interview (with referral and telephone booster) alone, BNI+facilitated provision of MAUD, BNI+facilitated provision of MAUD+CBT4CBT on AUD treatment engagement, alcohol use and healthcare utilization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/24/2025
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Alcohol Use Disorder
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Long-term Safety of Nipple Sparing Mastectomy in Women With GPV in Breast Cancer
NCT06888388
Recruiting
Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple areola complex but inquire as to whether it is safe to do so. Relative to traditional or skin sparing mastectomy (SSM) techniques, nipple sparing mastectomy (NSM) is associated with improved psychosocial and sexual well-being and is significantly better for body image and reducing feelings of disfigur... Read More
Gender:
FEMALE
Ages:
Between 18 years and 90 years
Trial Updated:
04/23/2025
Locations: Yale University, New Haven, Connecticut
Conditions: Breast Cancer Surgery
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Integrated Treatment for Enhancing Growth in Recovery During Adolescence
NCT06395467
Recruiting
This is a Phase II parallel group randomized controlled trial with 294 adolescents (age: 14-21 years) with alcohol and other drug \[AOD\] use disorder (hereafter substance use disorder), that compares two different active psychosocial interventions designed to address adolescent substance use disorder. Participants are recruited from our clinical settings and the community at two sites: one in the metro Boston, Massachusetts (MA) area and the other in the metro Farmington, Connecticut (CT), area... Read More
Gender:
ALL
Ages:
Between 14 years and 21 years
Trial Updated:
04/23/2025
Locations: UConn Health, Farmington, Connecticut
Conditions: Alcohol Use Disorder, Cannabis Use Disorder
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A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion
NCT06360354
Recruiting
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/23/2025
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis
NCT06329401
Recruiting
A randomized, double-blind, placebo-controlled clinical study to evaluate the safety and efficacy of 2 doses of inhaled pirfenidone (AP01) versus placebo on top of standard of care in participants with PPF over 52 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: UCONN Health, Farmington, Connecticut
Conditions: Progressive Pulmonary Fibrosis
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Becoming United in Lifestyle Decisions
NCT05796141
Recruiting
The goal of this project is to investigate how to enhance the effects of an online-only (mHealth) couples weight loss program. This study will use an innovative methodological framework, the Multiphase Optimization Strategy (MOST), to test four different strategies for weight loss and partner support in addition to a core intervention (i.e., dyadic action planning, joint feedback on goal progress, autonomy support training, and home environment modifications).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/23/2025
Locations: UConn's Weight Management Research Group, Hartford, Connecticut
Conditions: Overweight and Obesity
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A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa)
NCT06735755
Recruiting
This is a Phase 1/2, multicenter, open-label, single-ascending-dose study to evaluate the safety, tolerability, and efficacy of BEAM-301 in adult patients with GSDIa homozygous or compound heterozygous for the G6PC1 c.247C\>T (p.R83C) variant and to determine the optimal biological dose.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Clinical Study Site, Farmington, Connecticut
Conditions: Glycogen Storage Disease Type Ia
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Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder (ASD) Using Transcranial Magnetic Stimulation (TMS)
NCT06214065
Recruiting
The goal of this observational study is to test the modulation effect of different transcranial magnetic stimulation (TMS) on the neural network supporting our ability to create mental representations of others (also known as mentalizing) in young adults with autism. The main question it aims to answers is can stimulation of the right temporoparietal junction can change brain activity related to mentalizing during social interaction in the stimulation area and other brain areas connected to it.... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
04/22/2025
Locations: Olin Neuropsychiatry Research Center (ONRC), Hartford, Connecticut
Conditions: Autism Spectrum Disorder
Register for Updates