Connecticut is currently home to 1244 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Phase II Evaluation of Afatinib in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma
NCT02491099
Recruiting
Primary Objective: To assess the activity of Afatinib in patients with persistent or recurrent uterine serous carcinoma overexpressing HER2/neu with the frequency of patients who survive progression-free for at least 6 months after initiating therapy. Secondary Objectives: To assess objective response rate and durable disease control rate. To assess overall survival. To assess the safety profile of Afatinib in uterine serous carcinoma patients.
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
08/16/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: HER2/Neu+ Uterine Serous Carcinoma
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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
NCT05991453
Recruiting
The investigators will conduct a 12,500-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity
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Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records
NCT04569903
Recruiting
The primary objective of this study is to evaluate the diagnostic performance of an algorithm in identifying patients with ATTR amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Transthyretin Amyloidosis
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CBD-Microglia PET Study
NCT04398719
Recruiting
This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/14/2024
Locations: Connecticut Mental Health Center, New Haven, Connecticut
Conditions: CBD, Healthy
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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
NCT03678025
Recruiting
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Conditions: Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8
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Impact of Family-Centered Care for Intimate Partner Violence (IPV)
NCT06071299
Recruiting
The purpose of the study will be to determine how participation in Family-Centered Care (FCC) compared to Child-centered care (CCC) will affect caregiver engagement in IPV-based community services, caregiver perceptions of empowerment and survivor-defined practice, and clinical outcomes for children exposed to IPV.
Gender:
ALL
Ages:
3 years and below
Trial Updated:
08/13/2024
Locations: SCAN Clinic, Hartford, Connecticut
Conditions: Intimate Partner Violence
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Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
NCT06136195
Recruiting
The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.
Gender:
ALL
Ages:
Between 21 years and 50 years
Trial Updated:
08/12/2024
Locations: Connecticut Mental Health Center (SAC and SATU), New Haven, Connecticut
Conditions: Alcohol Consumption, Heavy Drinker, Alcohol Use Disorder (AUD)
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Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I
NCT02811510
Recruiting
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/12/2024
Locations: Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine, West Haven, Connecticut
Conditions: Cannabis
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Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans
NCT02781519
Recruiting
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
08/12/2024
Locations: Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine, West Haven, Connecticut
Conditions: Cannabis
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Neurofeedback From the Supplementary Motor Area for Tourette Syndrome
NCT05558566
Recruiting
This is a clinical trial where adolescents aged 10-16 years old with Tourette Syndrome (or chronic tic disorder) are randomized to receive either real-time functional magnetic resonance imaging (fMRI) neurofeedback targeting the supplementary motor area (for the experimental intervention) or real-time fMRI neurofeedback (NF) from a control region (for the control intervention).
Gender:
ALL
Ages:
Between 10 years and 16 years
Trial Updated:
08/09/2024
Locations: Yale University School of Medicine, New Haven, Connecticut
Conditions: Tourette Syndrome in Adolescence
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Pharmacist-led Intervention for Injectable HIV Treatment for Women With Health-related Social Needs
NCT06411223
Recruiting
This study addresses real-world use of long-acting injectable cabotegravir/rilpivirine (CAB/RPV LA) by evaluating implementation and clinical outcomes of a pharmacist-led collaborative drug therapy management model (CDTM+) that will be expanded for telehealth outreach to women with health-related social needs (HRSN).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: Yale Clinical and Community Research, New Haven, Connecticut
Conditions: Hiv
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Single Session Intervention to Promote Hope
NCT06375876
Recruiting
The purpose of this study is to develop a brief, self-guided single-session intervention (SSI) that targets the development of, or increase in, hope, and pilot test it for the primary outcomes of feasibility, acceptability/likeability, safety, and changes in hope, and the secondary outcomes of self-worth, empowerment, and emotional wellbeing among women experiencing intimate partner violence (IPV). The study will be conducted in 2 stages: intervention development (Intervention Development Stage)... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/08/2024
Locations: The Consultation Center at Yale, New Haven, Connecticut
Conditions: Domestic Violence
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