Connecticut is currently home to 1248 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
NCT05059626
Recruiting
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/04/2024
Locations: The John B. Pierce Laboratory, New Haven, Connecticut
Conditions: Endometriosis
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Sipuleucel-T Combined with Bipolar Androgen Therapy in Men with MCRPC
NCT06100705
Recruiting
This is an open-label, single-arm phase II study of bipolar androgen therapy (BAT) given in addition with standard of care Sipuleucel-T to determine the interferon (IFN) gamma Enzyme-linked Immunospot (ELISPOT) response rate to PA2024 (an engineered fusion protein of prostatic acid phosphatase and granulocyte-macrophage colony-stimulating factor which the activated autologous dendritic cells in the Sipuleucel-T vaccine are loaded with) in patients with metastatic castration resistant prostate ca... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2024
Locations: Yale Cancer Center, New Haven, Connecticut
Conditions: Metastatic Castration-resistant Prostate Cancer
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PRISM: Patient Experiences With PET Imaging in Prostate Cancer
NCT06523777
Recruiting
The purpose of this study is to examine patient experiences, health-related quality of life, and decision-making associated with PET imaging for prostate cancer. In particular, Prostate Specific Membrane Antigen (PSMA) PET, a new and more sensitive form of imaging that can help identify metastatic cancer earlier and more reliably.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/31/2024
Locations: Yale New Haven Health Bridgeport Hospital - Park Ave Medical Center, Bridgeport, Connecticut
Conditions: Prostate Cancer
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Intranasal Insulin for Posttraumatic Stress Disorder
NCT04044534
Recruiting
To evaluate if intranasal insulin is effective in reducing PTSD symptoms.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
10/31/2024
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: PTSD
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Safety and Efficacy of ALLO-316 in Subjects With Advanced or Metastatic Clear Cell Renal Cell Carcinoma
NCT04696731
Recruiting
This is a Phase 1 dose escalation study following a 3+3 study design. The purpose of the TRAVERSE study is to assess the safety, efficacy, and cell kinetics of ALLO-316 in adults with advanced or metastatic clear cell renal cell carcinoma after a lymphodepletion regimen comprising fludarabine, cyclophosphamide, and ALLO-647 to define a Phase 2 dose.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/30/2024
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Advanced/Metastatic Clear Cell Renal Cell Carcinoma
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Food for Thought - a Nutrition Intervention for Women Undergoing Active Treatment for Triple Negative Breast Cancer
NCT06582615
Recruiting
The goal of this randomized clinical trial is to learn if a healthy eating pattern called the MIND eating plan can reduce cancer-related cognitive impairment (commonly called "chemobrain") and other symptoms commonly experienced by women with newly diagnosed stage II-III triple negative breast cancer as they go through chemotherapy. The symptoms that will be measured include changes in memory and mental function, fatigue, sleep quality, anxiety, and depression. Researchers will compare measures... Read More
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
10/29/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage III Breast Cancer AJCC V8, Triple-Negative Breast Carcinoma
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The DRAGON 2 Trial
NCT05428735
Recruiting
In the randomized controlled DRAGON 2 trial study subjects will be randomized between two arms, PVE alone (control group) and PVE/HVE (interventional group).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/29/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR)
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Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
NCT04721418
Recruiting
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
10/29/2024
Locations: Connecticut Mental Health Center, New Haven, Connecticut
Conditions: Cocaine Use Disorder, Healthy Controls
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CAPO: Continuous Glucose Monitoring in A2 Gestational Diabetes and Pregnancy Outcomes
NCT04219085
Recruiting
This study will utilize continuous glucose monitoring in women with A2 gestational diabetes. Women will be randomized to continuous glucose monitoring or routine care with fingersticks to check their blood glucose four times daily. It is hypothesized that women in the continuous glucose monitoring arm will have a lower incidence of the composite primary outcome, which includes the following variables: perinatal death, shoulder dystocia, birth weight greater than 4,000 grams, NICU admission for t... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
10/25/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Gestational Diabetes, Maternal Complication of Pregnancy
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Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
NCT05486572
Recruiting
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mor... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
10/24/2024
Locations: VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut
Conditions: Carcinoma, Hepatocellular, Cirrhosis
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A Study to Learn How Different Amounts and Forms of the Study Medicine Called PF-06414300 Act in Healthy Adults
NCT06659250
Recruiting
The purpose of this study is to learn about how different amounts of study medicine called PF-06414300 acts and is changed and eliminated from the body of healthy adult participants. The amount of PF-06414300 in blood after the medicine is taken by mouth will also be measured. The study is seeking for participants who: * Are male or female of 18 to 65 years of age. * Are in good health condition. * Have body mass index of 16 to 32 kilograms per squared meters; and a total body weight of more t... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/23/2024
Locations: Pfizer Clinical Research Unit - New Haven, New Haven, Connecticut
Conditions: Healthy Participants
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Trial of Therapeutic Hypothermia in Patients With ARDS
NCT04545424
Recruiting
Acute Respiratory Distress Syndrome (ARDS) is a serious condition that occurs as a complication of medical and surgical diseases, has a mortality of \~40%, and has no known treatment other than optimization of support. Data from basic research, animal models, and retrospective studies, case series, and small prospective studies suggest that therapeutic hypothermia (TH) similar to that used for cardiac arrest may be lung protective in patients with ARDS; however, shivering is a major complication... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
10/23/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Respiratory Distress Syndrome, Adult
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