Connecticut is currently home to 1207 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including New Haven, Hartford, Farmington and Stamford. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery
NCT04197687
Recruiting
This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has residual disease after chemotherapy prior to surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is a type of vaccine made from HER2 peptide that may help the body build an effective immune response to kill tumor cells that express HER2. Sargramostim... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/15/2023
Locations: Middlesex Hospital, Middletown, Connecticut
Conditions: Breast Adenocarcinoma, Stage II Breast Cancer AJCC v6 and v7, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage III Breast Cancer AJCC v7, Stage IIIA Breast Cancer AJCC v7, Stage IIIB Breast Cancer AJCC v7, Stage IIIC Breast Cancer AJCC v7
Register for Updates
Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery
NCT05996133
Recruiting
The goal of this randomized, double-blinded, clinical trial is to assess the benefit of administering a Multifidus Cervicis Plane (MCP) block compared to a sham block as a method of postoperative pain control in patients undergoing posterior cervical spine fusion surgery. The main question it aims to answer is if the MCP block group will have reduced maximum pain scores during the first 24 postoperative hours compared to the sham block group. Participants will receive preoperative bilateral MCP... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
12/13/2023
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Cervical Spine Fusion
Register for Updates
Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
NCT05865041
Recruiting
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2023
Locations: 1 Site, New Haven, Connecticut
Conditions: Alopecia Areata
Register for Updates
Randomized Study Of Novel Enuresis Alarm vs Standard Bedwetting Alarm
NCT05214131
Recruiting
Identify the dry night rate in patients using the GoGoband® nocturnal enuresis device vs a standard Pflaundler bedwetting alarm.
Gender:
ALL
Ages:
Between 6 years and 21 years
Trial Updated:
12/11/2023
Locations: Yale New Haven Health, New Haven, Connecticut
Conditions: Bedwetting, Nocturnal Enuresis, Urinary Incontinence
Register for Updates
Study of Circulating Monocytes in Patients With Ischemic Vascular Disease
NCT04321512
Recruiting
The purpose of this research study is to discover the functions of circulating white blood cells, called monocytes, and associated circulating substances in heart attack and ischemic stroke patients. Ischemic Strokes (clots) occur as a result of an obstruction within a blood vessel supplying blood to the brain. A type of monocyte carrying a surface marker called "P2X4" helps the immune system sense and respond to danger signals from the body such as heart muscle and brain tissue injuries. The r... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Myocardial Infarction, Stroke, Ischemic, Ischemia
Register for Updates
Circulating Markers for Ischemic Heart Disease
NCT00762333
Recruiting
The purpose of this research is to determine if two proteins in the blood are increased during acute myocardial infarction and whether their levels are higher in those who develop heart failure than those who do not. These two proteins are produced and potentially released when the heart muscle is damaged. They may then be released into the blood and be detected by standard method in the research laboratory. At this time, detection of an increase in these proteins in the blood is not known to be... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Myocardial Infarction, Ischemia, Congestive Heart Failure
Register for Updates
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure
NCT00762008
Recruiting
The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Acute Decompensated Heart Failure, Heart Failure
Register for Updates
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
NCT05911568
Recruiting
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a moderate-to-severe disability prior to their stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2023
Locations: Hartford Health Hospital, Hartford, Connecticut
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic
Register for Updates
Characterizing Orthodontic Tooth Movement With Photographic Scans
NCT05780788
Recruiting
Characterizing orthodontic tooth movements in real time by using photographic scans to monitor teeth movement. The photographic scans will also be compared to 3D model scans. Canine retraction over the course of 1 orthodontic visit will be measured.
Gender:
ALL
Ages:
11 years and above
Trial Updated:
11/27/2023
Locations: UConn Health, Farmington, Connecticut
Conditions: Canine Retraction
Register for Updates
Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)
NCT04321759
Recruiting
To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service cente... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/13/2023
Locations: Hartford Hospital - Institute of Living, Hartford, Connecticut
Conditions: Schizophrenia and Related Disorders
Register for Updates
Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)
NCT05042102
Recruiting
The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/07/2023
Locations: VA Connecticut Healthcare System, West Haven, Connecticut
Conditions: Alcohol Use Disorder
Register for Updates
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
NCT01730781
Recruiting
The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis. The investigators will image brain cannabinoid receptors using Positron Emission Tomography (PET) imaging and the radioligand OMAR, in healthy individuals and several conditions including 1) cannabis use disorders, 2) psychotic disorders, 3) prodrome of psychotic illness and 4) individuals with... Read More
Gender:
MALE
Ages:
Between 18 years and 55 years
Trial Updated:
11/02/2023
Locations: Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut
Conditions: Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism, Healthy Control, Opioid-use Disorder, Post Traumatic Stress Disorder
Register for Updates