Iowa is currently home to 815 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and West Des Moines. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
MED-EL Remote Care Multi-Center Feasibility Study
NCT05973669
Recruiting
MED-EL Remote Care is a way for MED-EL cochlear implant users to check their hearing and cochlear implant device from any location, without the need for a scheduled, in-person appointment with their audiologist. This study will assess the effectiveness, efficiencies, and useability of MED-EL Remote Care.
Gender:
ALL
Ages:
All
Trial Updated:
06/03/2025
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Hearing Loss, Sensorineural, Cochlear Implant, Cochlear Implant Recipients, Hearing Disorders, Cochlear Implants
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Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss
NCT05821959
Recruiting
Part A of this trial will evaluate the safety and tolerability of a single unilateral administration of one of two dose levels of AAVAnc80-hOTOF and will evaluate the Akouos delivery device to safely achieve the intended product performance.
Gender:
ALL
Ages:
All
Trial Updated:
06/03/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Sensorineural Hearing Loss, Bilateral
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A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, or 7+3 in Patients With AML
NCT05735184
Recruiting
This Phase 1 study will assess the safety, tolerability, and preliminary antileukemic activity of ziftomenib in combination with venetoclax and azacitidine (ven/aza), ven, and 7+3 for two different molecularly-defined arms, NPM1-m and KMT2A-r.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: Acute Myeloid Leukemia, Mixed Lineage Acute Leukemia, Mixed Lineage Leukemia Gene Mutation, Mixed Phenotype Acute Leukemia, Refractory AML, AML With Mutated NPM1, Acute Myeloid Leukemia Recurrent, Acute Myeloid Leukemia, in Relapse, NPM1 Mutation, KMT2Ar, Myeloid Sarcoma
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Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
NCT03901924
Recruiting
The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Mechanical Ventilation Complication
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A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease
NCT03251118
Recruiting
TARGET-IBD is a 5-year, longitudinal, observational study of adult and pediatric patients (age 2 and above) being managed for Inflammatory Bowel Disease (IBD) in usual clinical practice. TARGET-IBD will create a research registry of patients with IBD within academic and community real-world practices in order to assess the safety and effectiveness of current and future therapies.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
06/03/2025
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Inflammatory Bowel Diseases, Crohn's Disease, Ulcerative Colitis, Indeterminate Colitis
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Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)
NCT06847282
Recruiting
The primary goal of this study is to validate motor and functional outcomes and refine clinical trial strategies for pediatric-onset FSHD
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
06/02/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Muscular Dystrophy, Facioscapulohumeral
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Hydrus® Microstent New Enrollment Post-Approval Study
NCT04553523
Recruiting
The purpose of this post-approval study is to evaluate the rate of Hydrus Microstent malposition and associated clinical sequelae occurring within 24 months post-operation. Qualified subjects will undergo uncomplicated cataract surgery with placement of a monofocal intraocular lens (IOL), followed by implantation of the Hydrus Microstent.
Gender:
ALL
Ages:
45 years and above
Trial Updated:
06/02/2025
Locations: Jones Eye Center PC, Sioux City, Iowa
Conditions: Primary Open Angle Glaucoma
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A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
NCT06151600
Recruiting
This is a multicenter, longitudinal, prospective observational natural history study of subjects with a molecularly confirmed diagnosis of CMT4J. The study will enroll 20 subjects of any age into a uniform protocol for follow-up and evaluations. Subject visits will occur every 12 months + 4 weeks for up to 2 years.
Gender:
ALL
Ages:
All
Trial Updated:
06/01/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Peripheral Neuropathy, Neuro-Degenerative Disease, Neuromuscular Diseases
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Aquagenic Wrinkling Prediction
NCT06831110
Recruiting
The goal of this observational study is to determine whether an aquagenic wrinkling procedure (i.e., soaking hands in a water bath for up to 20 minutes) can be used as a screening tool for cystic fibrosis carrier status. Participants will complete one visit where they will undergo an aquagenic wrinkling procedure to see how their hands respond.
Gender:
ALL
Ages:
Between 18 years and 24 years
Trial Updated:
05/30/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Aquagenic Wrinkling of Palms, Carrier State
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Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
NCT06605378
Recruiting
This research study is designed to assess the prevalence of specific antibodies and inflammatory cytokines in adult and pediatric participants with CGD.
Gender:
ALL
Ages:
All
Trial Updated:
05/30/2025
Locations: Home-based telemedicine, Des Moines, Iowa
Conditions: Chronic Granulomatous Disease (CGD)
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Oxytocin and Fetal Heart Rate Changes
NCT03232918
Recruiting
The reported risk of nonreassuring fetal heart trace following neuraxial analgesia is 3-23%. This variability may be due to fluid and oxytocin management prior to and during the initiation of neuraxial analgesia. The study hypothesis is that decreasing the oxytocin infusion rate by 50 % prior to initiation of combined spinal epidural analgesia will cause a reduction in the incidence of adverse fetal heart rate changes.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
05/30/2025
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Fetal Bradycardia Complicating Labor and Delivery, Fetal Bradycardia During Labor, Fetal Heart Rate or Rhythm Abnormality Affecting Fetus
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Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery
NCT06199999
Recruiting
The proposed intervention will examine two alternative methods for postoperative pain control. Two treatment arms of this study will include subjects who receive an erector spinae block (ESP) after induction of anesthesia but prior to the start of surgery and subjects who will receive a high volume of local anesthetic infiltration at the end of the procedure before emergence from anesthesia. The control group of subjects will undergo spinal surgery with general anesthesia but without any regiona... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/29/2025
Locations: University of Iowa Health Care Medical Center, Iowa City, Iowa
Conditions: Postoperative Delirium, Pain, Postoperative, Degenerative Disc Disease
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