Iowa is currently home to 806 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and Cedar Rapids. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
Recruiting
XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create a registry that will include entry of procedural and clinical follow-up information into an online data collection software, REDCAP.Data available since Jan 1 2005 will be included in the registry, until 14,000 patients have been included. The primary objectives of this observational registry study are to: Compare stent and non-stent bas... Read More
Gender:
All
Ages:
All
Trial Updated:
10/10/2023
Locations: Mid West Cardiovascular Research Foundation, Davenport, Iowa
Conditions: Peripheral Arterial Disease
Post-Approval Study of the TREO Abdominal Stent-Graft System
Recruiting
The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abdominal Aortic Aneurysms or Aorto-iliac Aneurysms.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: University of Iowa Hospital and Clinic, Iowa City, Iowa
Conditions: Abdominal Aortic Aneurysm
Optimizing the Previs Device for Prediction of Postoperative Ileus
Recruiting
The research proposed in this study will develop a noninvasive prototype device that will capture intestinal sounds, process signals, and display predictive information in real-time at the point-of-care using algorithms already developed at this institution.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
09/24/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Ileus
Conditioning SCID Infants Diagnosed Early
Recruiting
The investigators want to study if lower doses of chemotherapy will help babies with SCID to achieve good immunity with less short and long-term risks of complications after transplantation. This trial identifies babies with types of immune deficiencies that are most likely to succeed with this approach and offers them transplant early in life before they get severe infections or later if their infections are under control. It includes only patients receiving unrelated or mismatched related dono... Read More
Gender:
All
Ages:
Between 0 years and 2 years
Trial Updated:
09/15/2023
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: SCID
Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies
Recruiting
The use of bio-integrative implants in orthopedic surgery is growing exponentially. As many biomechanical and histological studies were able to sustain its structural and biological properties, few clinical studies are available to support its advantages, such as good osteosynthesis, lower rates of removal, and diminished implant-related artifact in imaging studies. This information is vital to providers when choosing the proper material and planning postoperative treatment. This trial intends t... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/31/2023
Locations: Departament of Orthopaedics and Rehabilitation, University of Iowa, Carver College of Medicine, Iowa City, Iowa
Conditions: Flatfoot, Bone Resorption, Cavus Deformity, Osteolysis, Complication
Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
Recruiting
This study will develop an algorithm of identifying patients with stage IV NSCLC and Melanoma who could benefit from cancer treatment they receive.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/25/2023
Locations: Helen Nassif Community Cancer Center, Cedar Rapids, Iowa
Conditions: Stage IV Non-small Cell Lung Cancer, Stage IV Small Cell Lung Cancer, Stage III Malignant Melanoma, Stage IV Malignant Melanoma
Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress
Recruiting
The purpose of this study is to evaluate the extent to which a single session of light to moderate intensity exercise performed within 30 minutes after receiving either the initial dose of COVID-19 mRNA vaccine may modify the immune response to vaccination, and identify potential underlying mechanisms using gene expression and metabolite analysis. A secondary goal is to establish whether psychosocial factors are associated with immune response to vaccination. Participants will be randomized to e... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
08/22/2023
Locations: Iowa State University, Ames, Iowa
Conditions: Immunization
Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort
Recruiting
The purpose of this research use only (RUO) study is to detect genomic structural variants (SVs) in human DNA by Optical Genome Mapping (OGM) using the Bionano Genomics Saphyr system. SVs are a type of genetic alternation that includes deletions, duplications, and both balanced and unbalanced rearrangements (ex: inversions or translocations), as well as specific repeat expansions and contractions. The results of OGM analysis will be compared to prior clinical genetic test results to determine ho... Read More
Gender:
All
Ages:
All
Trial Updated:
08/04/2023
Locations: University of Iowa Hospitals & Clinics, Molecular Pathology, Iowa City, Iowa
Conditions: Developmental Disability, Intellectual Disability, Autism Spectrum Disorder, Congenital Anomaly, Fragile X Syndrome, Facioscapulohumeral Muscular Dystrophy 1
TRIAD Appendicitis Decision-making Surveys
Recruiting
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative. Surgeons and patients alike have a difficult time deciding if surgery or antibiotics are the best choice to treat appendicitis. The goal of the TRIAD is to evaluate the patients who are a part of the TRIAD implementation program and assess satisfaction and decisional regret for patients w... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Appendicitis
Medication Empowerment and Deprescription for Safety (MEDS) Study
Recruiting
The long-term goal of this pragmatic, cluster randomized study is to develop a sustainable program for healthcare systems to reduce fatal and nonfatal falls among high-risk older adults living independently in their communities. This study will examine how a medication care plan, grounded in established medication deprescribing and tapering frameworks, can be implemented in primary care clinics to reduce falls among older adults living in rural Iowa communities. The study is a collaboration betw... Read More
Gender:
All
Ages:
Between 60 years and 110 years
Trial Updated:
05/08/2023
Locations: MercyOne Population Health Services, Clive, Iowa
Conditions: Aging, Fall Injury
SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects
Recruiting
This is a Phase 1/2a randomized, double-blind, two-part, dose-ascending, multicenter study of AR-501 (gallium citrate) solution, administered via inhalation, in healthy adult and P. aeruginosa infected cystic fibrosis (CF) subjects. Phase 1 of the study in HV subjects will consist of a single-ascending-dose (SAD) cohort, followed by the HV multiple-ascending-dose (MAD) cohort. Phase 2a of the study in CF subjects will consist of a MAD study design. The study will evaluate the safety and pharmaco... Read More
Gender:
All
Ages:
Between 18 years and 49 years
Trial Updated:
03/07/2023
Locations: Research Site, Iowa City, Iowa
Conditions: Cystic Fibrosis
MMP-9 Inhibition for Recalcitrant Wet AMD
Recruiting
Wet (or neovascular) form of age-related macular degeneration (wAMD) is the most common cause of blindness in the Western world. Currently, anti-vascular endothelial growth factor (VEGF) intravitreal injections (IVI) remain the standard-of-care treatment for wAMD. Previous studies show that about 90% of treated patients lose minimal visual function after 2 years of follow-up. There is still, a subset of 15% patients, incomplete responders, that do not improve and possibly worsen due to the persi... Read More
Gender:
All
Ages:
Between 50 years and 99 years
Trial Updated:
03/03/2023
Locations: University of Iowa Hospitals & Clinics Department of Ophthalmology & Visual Sciences, Iowa City, Iowa
Conditions: Exudative Macular Degeneration, Wet Age-related Macular Degeneration