Iowa is currently home to 819 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and Cedar Rapids. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT
Recruiting
The purpose of this study is to determine whether patients with acute kidney injury requiring renal replacement therapy have a higher incidence of muscle wasting than controls and whether the course of recovery is longer compared to controls.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
02/21/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Acute Kidney Injury, Critical Illness Myopathy, Dialysis; Complications
A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
Recruiting
This phase 3 randomized, open-label multicenter trial will compare the efficacy, safety and the impact on health-related quality of life (HR-QoL) of SPd versus EloPd in pomalidomide-naïve patients with MM who have received 1 to 4 prior anti-MM regimens and been treated with an immunomodulatory imide drug (IMiD), proteasome inhibitor (PI) and an anti-CD38 monoclonal antibody (mAb).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/20/2023
Locations: June E. Nylen Cancer Center, Sioux City, Iowa
Conditions: Multiple Myeloma
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
Recruiting
The purpose of this study is to assess the clinical effectiveness of all approved multiple myeloma (MM) therapies in the newly-diagnosed (NDMM) and the relapsed/refractory MM (RRMM) settings in real-world clinical practice.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2023
Locations: Local Institution - 0061, Des Moines, Iowa
Conditions: Multiple Myeloma
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects
Recruiting
The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma
Gender:
All
Ages:
1 year and above
Trial Updated:
02/15/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Neuroblastoma, Neuroectodermal Tumors, Neoplasms
Clinical Trial Readiness for the Dystroglycanopathies
Recruiting
The purpose of the study is to describe the early signs and symptoms of the dystroglycanopathies, and to gather information that will be required for future clinical trials.
Gender:
All
Ages:
All
Trial Updated:
02/13/2023
Locations: University of Iowa, 200 Hawkins Drive, Iowa City, Iowa
Conditions: Muscular Dystrophy
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT
Recruiting
The primary goal of this project is to develop and test a Charcot Marie Tooth disease (CMT) Pediatric Scale for use in evaluation in natural history CMT study.
Gender:
All
Ages:
21 years and below
Trial Updated:
02/10/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Charcot Marie Tooth Disease
Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
Recruiting
This project includes two projects. One is looking for new genes that cause Charcot Marie Tooth disease (CMT). The other is looking for genes that do not cause CMT, but may modify the symptoms a person has.
Gender:
All
Ages:
All
Trial Updated:
02/10/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Charcot-Marie-Tooth Disease, Type Ia (Disorder), HMSN
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
Recruiting
This is an observational longitudinal study to determine the natural history and genotype-phenotype correlations of disease causing mutations in Charcot Marie Tooth disease (CMT) type 1B (CMT1B), 2A (CMT2A), 4A (CMT4A), and 4C (CMT4C). The investigators will also be determine the capability of the newly developed CMT Pediatric Scale (CMT Peds scale) and the Minimal Dataset to measure impairment and perform longitudinal measurements in patients with multiple forms of CMT over a five year window
Gender:
All
Ages:
All
Trial Updated:
02/10/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Charcot Marie Tooth Disease
A Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose Compared to CHF 718 pMDI 800µg Total Daily Dose in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid
Recruiting
The purpose of this study is to compare the superiority of CHF 1535 compared to CHF 718 in subjects with asthma on medium or high dose inhaled corticosteroids.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/07/2023
Locations: Chiesi Clinical Trial Site 840805, West Des Moines, Iowa
Conditions: Asthma
A Clinical Trial Evaluating the Safety of Combining Lutathera(R) and Azedra(R) to Treat Mid-gut Neuroendocrine Tumors
Recruiting
This study is designed to identify the best tolerated doses of Lutathera® and Azedra® when co-administered to treat midgut neuroendocrine tumors. These drugs are radioactive drugs, known as radionuclide therapy, and are both approved in the treatment of midgut neuroendocrine tumor as single agents (not together). Currently, the safest and best tolerated doses of these drugs (when combined) is unknown. That is the purpose of this clinical trial.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/07/2023
Locations: Holden Comprehensive Cancer Center, Iowa City, Iowa
Conditions: Gastro-enteropancreatic Neuroendocrine Tumor, Neuroendocrine Tumors
Study of Descartes-30 in Acute Respiratory Distress Syndrome
Recruiting
Emergency study to test the safety of Descartes-30 cells in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) AND COVID-19
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Acute Respiratory Distress Syndrome, Covid19
Apixaban for the Acute Treatment of Venous Thromboembolism in Children
Recruiting
To assess the safety and descriptive efficacy of apixaban in pediatric subjects requiring anticoagulation for the treatment of a VTE.
Gender:
All
Ages:
Between 0 days and 17 years
Trial Updated:
02/06/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Venous Thromboembolism