Iowa is currently home to 798 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and West Des Moines. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA
Recruiting
The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the combination of its 3D nature and ability to image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable predictive models for osteoarthritis risk... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/07/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
Recruiting
XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create a registry that will include entry of procedural and clinical follow-up information into an online data collection software, REDCAP.Data available since Jan 1 2005 will be included in the registry, until 14,000 patients have been included. The primary objectives of this observational registry study are to: 1. Compare stent and non-stent... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2023
Locations: Mid West Cardiovascular Research Foundation, Davenport, Iowa
Conditions: Peripheral Arterial Disease
Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients
Recruiting
The trial aims to evaluate the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of Stage IIIB/C melanoma patients with respect to the standard of care (surgery and adjuvant therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Melanoma Stage IIIB/C
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
Recruiting
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: Iowa Diabetes Research, West Des Moines, Iowa
Conditions: Non-Alcoholic Fatty Liver Disease
Does the Use of Continuous Glucose Monitoring (CGM) in the Immediate Postpartum Period in Women With Pregestational Diabetes Admitted to the Hospital Decrease Hypoglycemic Episodes
Recruiting
This study will examine whether continuous glucose monitoring in patients hospitalized in the immediate postpartum period is more effective than traditional point of care glucose testing in identifying patients with hypoglycemia.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
11/20/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Pregestational Diabetes
8.4% Sodium Bicarbonate Locks in Intestinal Failure
Recruiting
We plan to include children with intestinal failure, a condition where the gut is not functioning properly, leading these children to need central venous catheters (line that goes through the skin into the blood stream) for nutritional support and hydration. Such patients have a very high risk for catheter infection. The study will include placing an agent (sodium bicarbonate) into the central catheter when the catheter is not in use. This is referred to as a lock. The lock would be used daily a... Read More
Gender:
ALL
Ages:
Between 1 year and 18 years
Trial Updated:
11/14/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Intestinal Failure, CRBSI - Catheter Related Bloodstream Infection
Optimizing the Previs Device for Prediction of Postoperative Ileus
Recruiting
The research proposed in this study will develop a noninvasive prototype device that will capture intestinal sounds, process signals, and display predictive information in real-time at the point-of-care using algorithms already developed at this institution.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
09/24/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Ileus
Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies
Recruiting
The use of bio-integrative implants in orthopedic surgery is growing exponentially. As many biomechanical and histological studies were able to sustain its structural and biological properties, few clinical studies are available to support its advantages, such as good osteosynthesis, lower rates of removal, and diminished implant-related artifact in imaging studies. This information is vital to providers when choosing the proper material and planning postoperative treatment. This trial intends t... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/31/2023
Locations: Departament of Orthopaedics and Rehabilitation, University of Iowa, Carver College of Medicine, Iowa City, Iowa
Conditions: Flatfoot, Bone Resorption, Cavus Deformity, Osteolysis, Complication
Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments
Recruiting
This study will develop an algorithm of identifying patients with stage IV NSCLC and Melanoma who could benefit from cancer treatment they receive.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/25/2023
Locations: Helen Nassif Community Cancer Center, Cedar Rapids, Iowa
Conditions: Stage IV Non-small Cell Lung Cancer, Stage IV Small Cell Lung Cancer, Stage III Malignant Melanoma, Stage IV Malignant Melanoma
Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress
Recruiting
The purpose of this study is to evaluate the extent to which a single session of light to moderate intensity exercise performed within 30 minutes after receiving either the initial dose of COVID-19 mRNA vaccine may modify the immune response to vaccination, and identify potential underlying mechanisms using gene expression and metabolite analysis. A secondary goal is to establish whether psychosocial factors are associated with immune response to vaccination. Participants will be randomized to e... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
08/22/2023
Locations: Iowa State University, Ames, Iowa
Conditions: Immunization
Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort
Recruiting
The purpose of this research use only (RUO) study is to detect genomic structural variants (SVs) in human DNA by Optical Genome Mapping (OGM) using the Bionano Genomics Saphyr system. SVs are a type of genetic alternation that includes deletions, duplications, and both balanced and unbalanced rearrangements (ex: inversions or translocations), as well as specific repeat expansions and contractions. The results of OGM analysis will be compared to prior clinical genetic test results to determine ho... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/04/2023
Locations: University of Iowa Hospitals & Clinics, Molecular Pathology, Iowa City, Iowa
Conditions: Developmental Disability, Intellectual Disability, Autism Spectrum Disorder, Congenital Anomaly, Fragile X Syndrome, Facioscapulohumeral Muscular Dystrophy 1
TRIAD Appendicitis Decision-making Surveys
Recruiting
While appendectomy has been the main treatment of appendicitis for over 100 years, recent European studies found that, at least among highly selected patients, antibiotics alone can be an effective alternative. Surgeons and patients alike have a difficult time deciding if surgery or antibiotics are the best choice to treat appendicitis. The goal of the TRIAD is to evaluate the patients who are a part of the TRIAD implementation program and assess satisfaction and decisional regret for patients w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Appendicitis