Iowa is currently home to 798 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Iowa City, Des Moines, Sioux City and West Des Moines. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Psilocybin-Assisted Vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
NCT05421065
Recruiting
This pilot study will collect preliminary data that measures the effects of psilocybin-assisted psychotherapy vs ketamine-assisted psychotherapy on patients struggling with alcohol use.
Gender:
MALE
Ages:
Between 25 years and 65 years
Trial Updated:
03/07/2025
Locations: University of Iowa, Iowa CIty, Iowa
Conditions: Alcohol Use Disorder
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Lurbinectedin in FET-Fused Tumors
NCT05918640
Recruiting
The purpose of this study is to find out if a drug called lurbinectedin (the "study drug") is safe and effective at treating people with recurrent or relapsed solid tumors, including Ewing sarcoma.
Gender:
ALL
Ages:
10 years and above
Trial Updated:
03/06/2025
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Ewing Sarcoma, Desmoplastic Small Round Cell Tumor, Pediatric Cancer, Undifferentiated Sarcoma
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Activity Levels in Bone Marrow Transplant Patients
NCT04115241
Recruiting
Participants in this study will be receiving a bone marrow transplant. This study is designed to evaluate correlations between activity levels and length of stay, quality of life, and hand grip strength.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/06/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Bone Marrow Transplant
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Sleep Apnea in Patients with MGUS and MM
NCT04114084
Recruiting
This study involves patients with plasma cell dyscrasia including monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM), with and without sleep apnea, who are providing bone marrow specimens. Specimens will be obtained at the time that patients undergo a standard-of-care procedure in order to minimize discomfort and reduce any risk.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/06/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance
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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT05890729
Recruiting
A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Xentria Investigative Site, Iowa City, Iowa
Conditions: Pulmonary Sarcoidosis
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Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab
NCT05363631
Recruiting
The purpose of this research study is to test the safety and effectiveness of Seleno-L Methionine (SLM) when combined with the standard dose and schedule of Axitinib and Pembrolizumab in patients who have locally advanced or metastatic clear cell renal cell carcinoma (ccRCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: Clear Cell Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma Metastatic
Register for Updates
Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
NCT06267391
Recruiting
This study is designed to evaluate the safety and effectiveness of endoscopic intestinal re-cellularization therapy in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering medications.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/03/2025
Locations: Heartland Medical Research, Inc., Clive, Iowa
Conditions: Type 2 Diabetes Mellitus, Type2diabetes, Diabetes Mellitus, Type 2, Diabetes, Type 2 Diabetes
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Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
NCT04817618
Recruiting
The Primary Completion Date and Study Completion Date have been updated to reflect completion of the adolescent cohort, which has been added to the protocol. The study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy.
Gender:
ALL
Ages:
Between 12 years and 60 years
Trial Updated:
03/01/2025
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: C3G
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Cochlear Implant Speech in Noise Processing
NCT06860152
Recruiting
The study will help us in understanding the neural mechanisms by which listeners with a cochlear implant detect speech in noisy environments.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/27/2025
Locations: University of Iowa, Iowa City, Iowa
Conditions: Hearing Loss, Adult-Onset, Speech Intelligibility, Hearing Loss, Extreme
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Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
NCT03954899
Recruiting
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment (MCI+) and those who are not (MCI-). AD biomarkers will be measured from cerebrospinal fluid (CSF) obtained from lumbar punctures. Cognitive function will be evaluated with routine neuropsychological tests. AS OF AUGUST 2024, THE LUMBAR PUNCTURE PROCEDURES FOR THIS CLINICA... Read More
Gender:
ALL
Ages:
Between 56 years and 85 years
Trial Updated:
02/27/2025
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
NCT05874921
Recruiting
The purpose of this registry is to evaluate real world experience and outcomes of patients with Upper Tract Urothelial Cancer (UTUC) treated with Jelmyto in the United States.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: The State University of Iowa, Iowa City, Iowa
Conditions: Urothelial Carcinoma, Urothelial Carcinoma Recurrent, Urothelial Carcinoma Ureter, Urothelial Carcinoma Ureter Recurrent, Urothelial Cancer of Renal Pelvis, Urothelial Carcinoma of the Renal Pelvis and Ureter, Carcinoma, Transitional Cell, Transitional Cell Carcinoma of Renal Pelvis
Register for Updates
University of Iowa Interventional Psychiatry Service Patient Registry
NCT04480918
Recruiting
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/25/2025
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Obsessive-Compulsive Disorder
Register for Updates