Minnesota is currently home to 2105 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PV Loop & Coarctation Study
NCT05362721
Recruiting
Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.
Gender:
ALL
Ages:
6 years and above
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Coarctation of Aorta
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Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
NCT05062369
Recruiting
The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct current stimulation (tDCS) for new treatments for alcohol use disorder (AUD) that support long-term abstinence. This study will allow the investigators to discern whether the pairing of dorsolateral prefrontal cortex (DLPFC) stimulation and cognitive training can lead to impr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Alcohol Use Disorder, Addiction
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Evaluation of an Explicit Approach
NCT04902508
Recruiting
This study is a randomized clinical trial that uses a Sequential Multiple Assignment Randomized Trial (SMART) study design. The study will directly compare the efficacy of an innovative intervention that combines explicit and implicit approaches to a traditional implicit treatment approach to teach true grammatical forms to children with developmental language disorder (DLD). The study will also compare interventions that include sequences of Explicit-added and Implicit-only treatments. Particip... Read More
Gender:
ALL
Ages:
Between 5 years and 9 years
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Developmental Language Disorder, Explicit Intervention, Grammatical Language
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Epidural Stimulation After Neurologic Damage
NCT03026816
Recruiting
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement. The study will also characterize improvement in autonomic function (such as blood pressure control) and other functions related to spinal cord injury.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/21/2025
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: Spinal Cord Injuries, Paraplegia, Complete
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University of Minnesota Transplant Registry
NCT01062581
Recruiting
Under Transplant Information Services (TIS), the University of Minnesota Transplant Registry (UMTR) will serve as the repository for core research data.
Gender:
ALL
Ages:
All
Trial Updated:
03/21/2025
Locations: University of Minnesota Transplant Information Services, Minneapolis, Minnesota
Conditions: Transplant Recipient, Transplant Donation
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Assessment of Risks of Perinephric Fat Thickness to Adverse Renal Outcomes Post Donor Nephrectomy
NCT06886087
Recruiting
The goal of this observational study is to learn if PRAT thickness is a marker of visceral obesity and its influence on donors' kidney function and blood pressure in living kidney donors. Population includes male/female, 18 years and up, living kidney donors scheduled for nephrectomy within 6 months, with a BMI of ≤ 27 or \>30, with a PRAT thickness measurement of ≥ 14mm or ≤10mm on CT. The main area it aims to help in, is future care managing blood pressure and obesity in living kidney transpla... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/20/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Living Kidney Donation, Hypertension, Nephrectomy
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Acute Recording of Stereotyped High-Frequency Oscillations
NCT05439655
Recruiting
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver t... Read More
Gender:
ALL
Ages:
Between 3 years and 70 years
Trial Updated:
03/20/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Epilepsy
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Cephea Early Feasibility Study
NCT05061004
Recruiting
The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral stenosis and mixed mitral valve disease) in whom transcatheter therapy is deemed more appropriate than open heart surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Minneapolis Heart Institute, Minneapolis, Minnesota
Conditions: Mitral Regurgitation
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Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial
NCT06080698
Recruiting
The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream Infection (GN-BSI) is as effective but safer than remaining on intravenous (IV) antibiotic therapy for the duration of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Gram-negative Bacteremia
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R-5280 in Newly Diagnosed Patients with Type 1 Diabetes
NCT06057454
Recruiting
Evaluating the adverse events and tolerance of R-5280 in Mitigating Type 1 Diabetes in Newly Diagnosed Patients
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
03/19/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Type 1 Diabetes, Type 1 Diabetes (Juvenile Onset), Diabetes Mellitus, Type 1
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INTERogating Cancer for Etiology, Prevention and Therapy Navigation
NCT06008392
Recruiting
This study is being done to identify markers and causes of cancer by analyzing patient's DNA (i.e., genetic material), RNA, plasma, tissues, or other samples that could be informative for patients with cancer. Cancer genetic testing is a series of tests that finds specific changes in cancer cells and normal cells in the body. Researchers may request to access these data as they explore how to better prevent, screen, or treat cancer. This study is also being done to create a biobank (library) of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cancer, Cancer Gene Mutation, PAN Gene Mutation, Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
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R-3750 in Patients with Mild to Moderate Ulcerative Colitis
NCT05666960
Recruiting
The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate ulcerative colitis. Patients will take an oral dosage of probiotic (R-3750) and provide patient-reported and physician scored measures of their colitis. Blood and fecal evaluations of inflammation and assessment of probiotic (R-3750) on fecal levels will also be measured.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/19/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic, Ulcerative Colitis
Register for Updates