Minnesota is currently home to 2101 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Arnica and the Management of Pain in Acute Musculoskeletal Extremity Injuries
NCT05283434
Recruiting
In the Emergency Department, there is no standard of care for pain medication distribution for children with an acute musculoskeletal injury when there is no fracture present. Currently, ibuprofen is a favorable choice for the treatment, but studies have shown concern for delayed healing activity associated with NSAIDs like Ibuprofen. Homeopathic Arnica Montana is a well-established complimentary medicine and may provide a good alternative for managing acute pain from musculoskeletal injuries, e... Read More
Gender:
All
Ages:
Between 11 years and 18 years
Trial Updated:
03/07/2022
Locations: Children's Minnesota, Minneapolis, Minnesota
Conditions: Pain, Muscle, Pain, Acute
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NOVOCART®3D for Treatment of Articular Cartilage of the Knee
NCT01957722
Recruiting
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/01/2022
Locations: Tria Orthopedic Center, Bloomington, Minnesota
Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
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MultiStem® Administration for Stroke Treatment and Enhanced Recovery Study
NCT03545607
Recruiting
A Phase 3 study to examine the safety and effectiveness of the allogeneic, adult stem cell investigational product, MultiStem, in adults who have suffered an acute ischemic stroke in the previous 18-36 hours.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/08/2022
Locations: Athersys Investigational Site 125, Minneapolis, Minnesota
Conditions: Ischemic Stroke
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Safety and Durability of Sirolimus for Treatment of LAM
NCT02432560
Recruiting
The MIDAS study aims to follow LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Lymphangioleiomyomatosis
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Minnesota RETAIN Impact Evaluation
NCT05146349
Recruiting
This study is a randomized control trial (RCT) to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. Collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay at work and return to work will be implemented.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/07/2022
Locations: Mn Retain, Mayo Clinic, Rochester, Minnesota
Conditions: Any Injury or Illness Acutely Impacting Work
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Prediction of Outcomes After Surgery for Unruptured Intracranial Aneurysms
NCT04819074
Recruiting
Accurate preoperative identification of patients at high risk for adverse outcomes would be clinically advantageous, as it would allow enhanced resource preparation, better surgical decision-making, enhanced patient education and informed consent, and potentially even modification of certain modifiable risk factors. The aim of the Prediction of adverse events after microsurgery for intracranial unruptured aneurysms (PRAEMIUM) study is therefore to develop and externally validate a clinically app... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2021
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Aneurysm, Brain
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The HALT Biomarker Study
NCT04552275
Recruiting
The purpose of the HALT Biomarkers study are to identify a panel of circulating proteins that discriminates between patients with and without Hypo-Attenuated Leaflet Thickening (HALT) and can be used to supplement the diagnosis of HALT; to characterize changes in circulating proteins after treatment of HALT with systemic anticoagulation; and to identify circulating proteins that predict the occurrence of HALT. The study population will be adult patients undergoing transfemoral transcatheter aor... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
11/02/2021
Locations: Minneapolis Heart Institute, Minneapolis, Minnesota
Conditions: Aortic Stenosis, Hypo-attenuated Leaflet Thickening, Bioprosthetic Valve Degeneration
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Progress Complication
NCT05100940
Recruiting
Coronary angiography and percutaneous coronary intervention (PCI) is often performed in patients with ischemic heart disease. The safety of PCI has improved with new devices and strategies, but complications still occur, especially during complex procedures. The objectives of this multi-center observational registry are to examine frequency of complications occuring during cardiac catheterization and PCI, examine procedural strategies utilized for complication management, and evaluate the clinic... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/20/2021
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Coronary Artery Disease
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Progress Bifurcation Global Registry
NCT05100992
Recruiting
Coronary bifurcation lesions are lesions (or blockages) that occur at or near the intersection of a major coronary artery and one of the arteries' side branches. Numerous techniques and devices have been developed to treat coronary bifurcations; however, these types of lesions remain some of the most challenging, both in terms of procedural success and outcome. This study is designed as an observational, multi-center registry that will collect information on treatment strategies and outcomes of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/20/2021
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Coronary Artery Disease, Coronary Bifurcation Lesions
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Iso-Osmolar vs. Low-Osmolar Contrast Agents for Optical Coherence Tomography
NCT05065073
Recruiting
The proposed study aims to compare (a) volume contrast administered for Optical Coherence Tomography (OCT) Imaging, (b) length of clear OCT images, and (c) electrocardiographic changes immediately after contrast injection between iso-osmolar and low-osmolar contrast agents. The proposed study is a prospective, single-centered, randomized controlled, study that will compare an iso-osmolar vs. a low-osmolar contrast agent in patients undergoing clinically indicated coronary OCT imaging. Each patie... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/19/2021
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Coronary Artery Disease, Contrast Media Reaction
Register for Updates
Effects of CRT Optimization as Assessed by Cardiac MR
NCT04763460
Recruiting
Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical dyssynchrony. A traditional CRT device has pacing leads implanted within the right atrium (RA), the right ventricle (RV), and within a coronary vein overlying the lateral or posterior left ventricle (LV). Within the past decade, various multi-center randomized controlled... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
09/21/2021
Locations: Minneapolis Heart Institute - Abbott Northwestern Hospital (MHI West), Minneapolis, Minnesota
Conditions: Heart Failure, Systolic
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Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
NCT01835028
Recruiting
Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed (i.e. Classical LF; CLF) or preserved (i.e. Paradoxical LF; PLF) LV ejection fraction (LVEF) and both situations are amongst the most challenging encountered in patients with valvular heart disease. Although, CLF-LG AS is recognized has an important clinical entity, current ACC/AHA-ESC guidelines however do not provide precise recommendations for clinical management of these patients . PLF-LG AS is a new entity recently... Read More
Gender:
All
Ages:
Between 21 years and 90 years
Trial Updated:
09/20/2021
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Aortic Valve Stenosis
Register for Updates