Minnesota is currently home to 2105 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
NCT05205174
Recruiting
Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.
Gender:
ALL
Ages:
All
Trial Updated:
02/04/2025
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: TBI (Traumatic Brain Injury)
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Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)
NCT04494347
Recruiting
WATCH-TMVR (Watchman for Patients with Atrial Fibrillation Undergoing Transcatheter Mitral Valve) Clinical Trial have the main objective to assess the feasibility of combining clinically indicated MitraClip TMVR and Watchman LAAO in one setting.Mayo Clinic will be the data coordinating center for this trial, which will include up to 3 sites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Nonvalvular Atrial Fibrillation, Severe Degenerative Mitral Regurgitation
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A Randomized Multicenter Study for Isolated Skin Vasculitis
NCT02939573
Recruiting
Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Primary Cutaneous Vasculitis, Cutaneous Polyarteritis Nodosa, IgA Vasculitis, Henoch-Schönlein Purpura
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Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study
NCT06770062
Recruiting
The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Left Ventricular Systolic Dysfunction
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Standardized Microbiota Transplant Therapy in Crohn's Disease
NCT06631586
Recruiting
Crohn's disease (CD) develops because of a disruption of homeostasis between the gut microbiota and the host immune system resulting in excessive inflammation in the intestinal tract. Current drug therapies for CD are directed at the immune system. The emergence of fecal microbiota transplantation (FMT) for the treatment of recurrent C. difficile infections (rCDI) has opened a frontier of restorative therapies targeting the gut microbiome. This study aims to assess if two forms of encapsulated F... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/03/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Crohn Disease
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AT ELANA 841P Posterior Chamber Intraocular Lens for Correction of Aphakia Following Cataract Removal
NCT06264232
Recruiting
The goal of this clinical trial is to demonstrate the safety and effectiveness of the full visual range AT ELANA 841P IOL when used to treat adult patients having cataract surgery. Subjects will be randomly selected to receive a pair of IOLs, either the AT ELANA 841P or CT LUCIA 621P lens design. All patients will undergo surgery in both eyes, and they will receive follow up care for up to 6-months. During this time, all patients will undergo thorough eye exams at every study visit and complete... Read More
Gender:
ALL
Ages:
Between 22 years and 100 years
Trial Updated:
02/03/2025
Locations: Chu Vision Institute, Bloomington, Minnesota
Conditions: Cataract Senile
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SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes
NCT06149793
Recruiting
This will be a placebo-controlled, randomized, double blind, crossover study with a 4 week wash out period. Collect pilot data on the safety, tolerability, and feasibility of empagliflozin therapy in overweight/obese patients with CFRD to support a future larger randomized controlled trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Cystic Fibrosis-related Diabetes, Cystic Fibrosis
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SELUTION 4 De Novo Small Vessel IDE Trial
NCT05946629
Recruiting
Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to 2.75 mm, in support of a pre-market approval (PMA) application to the United States (US) FDA. The Study will enroll up to 910 randomized subjects, up to 30 subjects in a parallel angiographic substudy, and up to 20 subjects in a par... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Minneapolis Heart Institute, Minneapolis, Minnesota
Conditions: Coronary Artery Disease
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Gait Adaptation and Biofeedback for Cerebral Palsy
NCT05899153
Recruiting
This research aims to evaluate walking function in children with cerebral palsy (CP). The researchers want to understand how children with CP adapt and learn new ways of moving. They have previously found that measuring how a person controls their muscles is important for assessing walking ability and response to interventions. In these studies, they will adjust the treadmill belt speeds and/or provide real-time feedback to evaluate how a child can alter their movement. The feedback will include... Read More
Gender:
ALL
Ages:
Between 7 years and 18 years
Trial Updated:
02/03/2025
Locations: Gillette Children's, Saint Paul, Minnesota
Conditions: Cerebral Palsy
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Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
NCT05074810
Recruiting
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with sotorasib with or without defactinib in patients with KRAS G12C Non-Small Cell Lung Cancer (NSCLC) in patients who have been exposed to prior G12C inhibitor and those who have not been exposed to prior G12C inhibitor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Minnesota Oncology Hematology, P.A, Woodbury, Minnesota
Conditions: Non Small Cell Lung Cancer, KRAS Activating Mutation
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Statins for the Treatment of NASH
NCT04679376
Recruiting
The purpose of this research study is to determine whether the study drug, atorvastatin (Lipitor®), is safe and effective in improving the features of NASH.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/03/2025
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: NASH - Nonalcoholic Steatohepatitis
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Shared Decision Making to Improve Goals of Care in the ED
NCT03833622
Recruiting
This project will develop and refine a shared decision making (SDM) intervention (decision aid tool) to improve and normalize high quality end of life discussions in the Emergency Department (ED) setting.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/03/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Goals
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