Minnesota is currently home to 2064 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial
NCT06285253
Recruiting
The clinical trail will assess the safety of miroliverELAP for the treatment of acute liver failure without underlying chronic liver disease. miroliverELAP is an external liver assist combination product consisting of a single-use MIRO-001 bioengineered liver graft and an extracorporeal blood circuit. miroliverELAP Is intended to support the native (failed) liver for up to 48-hours of continuous treatment to allow time for liver recovery or to identify a transplantable liver.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/21/2025
Locations: University of Minnesota Medical School, Minneapolis, Minnesota
Conditions: Acute Liver Failure, Acute Liver Injury, Drug Induced
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Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
NCT06282575
Recruiting
The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/21/2025
Locations: Minnesota Oncology Hematology, P.A., Maple Grove, Minnesota
Conditions: Biliary Tract Cancer
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Efficacy of Nerve Blocks for Episodic Migraine
NCT05734625
Recruiting
The purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our hypothesis is that the pain of most episodic migraine headaches can be eliminated and prevented for months by blocking the nerves that give pain sensation during a migraine.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/21/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Episodic Migraine
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Epidural Stimulation After Neurologic Damage: Long-Term Outcomes
NCT05705453
Recruiting
This study will evaluate the long-term effect of chronic spinal cord stimulation to restore volitional movement for patients with chronic spinal cord injuries.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/21/2025
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: SCI - Spinal Cord Injury
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Long Term Followup of Patients Enrolled in MC1137, BEAUTY Study
NCT05703399
Recruiting
This study gathers information and samples for further analysis as part of the BEAUTY study. The purpose of the BEAUTY study was to better understand the reasons why or why not breast cancers respond to standard chemotherapy. Collecting samples of blood and tissue and health and treatment information from patients on the BEAUTY study may help doctors identify changes that make cancer better respond to standard chemotherapy and develop better therapies for the treatment of cancer.
Gender:
ALL
Ages:
All
Trial Updated:
03/21/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Breast Carcinoma
Register for Updates
Udall Project 2 Aim 2A&C
NCT05656586
Recruiting
This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC DBS system to study the effects of globus pallidus internus and globus pallidus externus (GPi, GPe) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over 4 weeks). These experiments will elucidate the relationships betwee... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson Disease
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Evaluation of the SCALED (SCaling AcceptabLE cDs)
NCT05628207
Recruiting
This project will adapt a currently deployed Clinical Decision Support (CDS) system to deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI). We believe this is an ideal PCOR use case given PCORI's continued effort to combat VTE in trauma and our experience previously implementing this guideline. The Our overall goal is to successfully scale, evaluate, and maintain an interoperable TBI CDS across 7 total institutions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Traumatic Brain Injury, Venous Thromboembolism
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ASSESSING THE GAY MALE EXPERIENCE WITH ANAL CANCER PREVENTION STRATEGIES
NCT05628194
Recruiting
The purpose of this study is to describe current knowledge and opinions about anal cancer screening among men who have sex with men (MSM), as well as their experience receiving guideline-compliant care aimed at anal cancer risk reduction using a large-scale survey disseminated via social media.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Anal Cancer
Register for Updates
PV Loop & Coarctation Study
NCT05362721
Recruiting
Coarctation of the aorta accounts for 4-7% of all congenital heart disease. While stent therapy, when feasible, is the standard of care for coarctation, it may not completely improve the work (and afterload) of the heart due to its effects on the elasticity of the aorta. This study will provide the information needed to understand the effects of current management on the cardiac mechanics and work.
Gender:
ALL
Ages:
6 years and above
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Coarctation of Aorta
Register for Updates
EPI-MINN: Targeting Cognition and Motivation
NCT05112432
Recruiting
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using a 12-week mobile intervention program. Participants who are enrolled in a chart review study of measurement-based care will be recruited to participate in this study. In the measurement-based care study, participants are enrolled in coordinated specialty care programs fo... Read More
Gender:
ALL
Ages:
Between 15 years and 40 years
Trial Updated:
03/21/2025
Locations: Human Development Center, Duluth, Minnesota
Conditions: Psychosis
Register for Updates
Tdcs And cogNitive traininG cOmbined for AUD (TANGO)
NCT05062369
Recruiting
The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct current stimulation (tDCS) for new treatments for alcohol use disorder (AUD) that support long-term abstinence. This study will allow the investigators to discern whether the pairing of dorsolateral prefrontal cortex (DLPFC) stimulation and cognitive training can lead to impr... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Alcohol Use Disorder, Addiction
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Evaluation of an Explicit Approach
NCT04902508
Recruiting
This study is a randomized clinical trial that uses a Sequential Multiple Assignment Randomized Trial (SMART) study design. The study will directly compare the efficacy of an innovative intervention that combines explicit and implicit approaches to a traditional implicit treatment approach to teach true grammatical forms to children with developmental language disorder (DLD). The study will also compare interventions that include sequences of Explicit-added and Implicit-only treatments. Particip... Read More
Gender:
ALL
Ages:
Between 5 years and 9 years
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Developmental Language Disorder, Explicit Intervention, Grammatical Language
Register for Updates