Minnesota is currently home to 2063 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
NCT04174157
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases. The purpose of this registry is to assess the long term outcomes of patients with SMA in the c... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Spinal Muscular Atrophy (SMA)
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Bupropion for the Prevention of Postpartum Smoking Relapse
NCT04098874
Recruiting
This two-arm, double-blind, placebo-controlled randomized clinical trial will enroll pregnant women who quit smoking after learning they were pregnant and are motivated to stay abstinent postpartum. Participants will be randomized to receive extended-release bupropion (active 300mg or placebo once daily beginning 4 to 10 days postpartum to 12 weeks post-randomization). All participants will complete the same data collection procedures (e.g., biological sample collection for hormone and cotinine... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
01/30/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Postpartum Smoking Relapse
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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
NCT04031677
Recruiting
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Conditions: Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
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Algorithms for Programming DBS Systems for ET
NCT03984643
Recruiting
Deep brain stimulation (DBS) targeting the Vim thalamus (ventralis intermedius nucleus) is an FDA-approved neuromodulation therapy for treating postural and action tremor in individuals with essential tremor (ET). The success of this treatment, however, is highly dependent on the ability of clinicians to identify therapeutic stimulation settings through a laborious programming process. There is a strong and growing clinical need for new approaches to provide clinicians with more efficient guidan... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/30/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Essential Tremor
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Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases
NCT06788886
Recruiting
This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relationship between respiration, cardiovascular effects in the brain, mental health, and neurophysiological mechanisms are significant for patient populations facing complex health challenges, such as those with cancer and neurodegenerative disease, and their caregivers. By measuring oxygen delivery to brai... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/29/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Malignant Brain Neoplasm, Malignant Solid Neoplasm, Multiple Sclerosis, Neuroendocrine Tumor, Prostate Carcinoma
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Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
NCT05787821
Recruiting
The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis
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A Study to Assess Pregnancy Outcomes in Women Exposed to Diroximel Fumarate
NCT05688436
Recruiting
The primary objective of the study is to estimate the prevalence of major congenital malformations (MCMs) and compare the prevalence between the diroximel fumarate (DRF) and comparator groups. The secondary objectives of the study are to estimate the incidence of spontaneous abortion (SA) and compare the incidence between the DRF and comparator groups; to estimate the incidence of preterm birth and compare the incidence between the DRF and comparator groups; to estimate the incidence of stillbir... Read More
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
01/29/2025
Locations: OptumInsight, Eden Prairie, Minnesota
Conditions: Multiple Sclerosis
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Persona Revision Knee System Outcomes
NCT04821154
Recruiting
The study will evaluate the performance, clinical benefits and safety of the Persona Revision Knee System in patients who have received primary or revision total knee arthroplasty (TKA) treatment. This will be done using a multicenter, single-arm, consecutive series, retrospective cohort study with prospective follow-up.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: TRIA Orthopaedic Center Research Institute, Bloomington, Minnesota
Conditions: Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis
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Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
NCT03433274
Recruiting
Prospective, controlled, multicenter clinical investigation with four trial cohorts: Randomized, Non-repairable, Severe Mitral Annular Calcification (MAC) and Severe Mitral Annular Calcification Continued Access Protocol (MAC CAP). Subjects in the Randomized cohort will be randomized in a 1:1 ratio to the trial device or to the MitraClip system. Subjects in the Non-repairable, Severe MAC, and Severe MAC CAP cohorts will receive the trial device. The objective of the Clinical Trial to Evaluate t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Abbott Northwestern Hospital, Minneapolis, Minnesota
Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
Register for Updates
CIBMTR Research Database
NCT01166009
Recruiting
The primary purpose of the Research Database is to have a comprehensive source of observational data that can be used to study HSC transplantation and cellular therapies. A secondary purpose of the Research Database is to have a comprehensive source of data to study marrow toxic injuries. Objectives: To learn more about what makes stem cell transplants and cellular therapies work well such as: * Determine how well recipients recover from their transplants or cellular therapy; * Determine how... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/29/2025
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Autologous Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, Solid Tumors, Blood Cancers, CAR-T, Gene Therapy, Non-malignant Disease
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DESIFOR-EXPAND (MHIF)
NCT06804980
Recruiting
The DESIFOR pilot study was conducted to determine the feasibility of utilizing an n-of-1 trial to facilitate tolerance of unblinded rosuvastatin in patients with prior statin intolerance
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/28/2025
Locations: Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Conditions: Statin Therapy, Statin Adverse Reaction, Statin
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Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
NCT06271291
Recruiting
This study evaluates individuals without pancreatic cancer, but who have been determined to be at higher-than-average lifetime risk of developing pancreatic cancer to help detect pancreatic cancer or other cancers at an earlier time when they might be more easily treated and cured.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/28/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Pancreatic Carcinoma
Register for Updates