Minnesota is currently home to 2090 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study of Entresto in Tetralogy of Fallot (TOF) and Ebstein's Anomaly (EA)
NCT06693674
Recruiting
The purpose of this study is to compare changes in RV structure and function, biomarkers, and patient reported outcomes between TOF patients randomized to an ARNI vs placebo.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Tetralogy of Fallot, Ebstein's Anomaly
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Functional Improvement in OSA and COPD with a Telehealth LifeStyle and Exercise Intervention
NCT06390345
Recruiting
The investigators will conduct a Type I hybrid effectiveness-implementation study to test an integrated telehealth intervention among 400 overweight and obese patients with Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA). The investigators will include eligible participants receiving primary care at one of five Department of Veterans Affairs (VA) medical centers and their community-based outpatient clinics. The investigators will randomize patients in a 1:1 ratio t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Minneapolis VA Health Care System, Minneapolis, Minnesota
Conditions: Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, Overweight and Obesity
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Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer
NCT06350097
Recruiting
The purpose of this study is to evaluate efficacy and safety of osimertinib (tablet) in combination with Datopotamab Deruxtecan (i.v. infusion) compared with osimertinib (tablet) monotherapy as a first-line therapy in participants with locally advanced or metastatic EGFRm (Ex19del and/or L858R) NSCLC. Study details include: 1. The study duration will be event-driven, with an estimated duration of approximately 9 years. 2. Participants may receive study treatment until disease progression, unac... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Research Site, Saint Paul, Minnesota
Conditions: Non-small Cell Lung Cancer
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Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta
NCT05972551
Recruiting
The primary objective of this study is to evaluate the effect of romosozumab treatment for 12-months compared with bisphosphonate(s) on the number of clinical fractures at 12-months; the number of any fractures at 12-months and change in lumbar spine bone mineral density (BMD) Z-score at 6-months.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
03/12/2025
Locations: Mayo Clinic Childrens Center, Rochester, Minnesota
Conditions: Osteogenesis Imperfecta
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ETHAN - ET for Male BC
NCT05501704
Recruiting
This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male breast cancer. The drugs used in this study are: * Tamoxifen * Anastrozole * Degarelix * Abemaciclib
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Male Breast Cancer, Hormone Receptor-positive Breast Cancer, Hormone Receptor Negative Breast Carcinoma
Register for Updates
Stimulating After Recovery From Traumatic Brain Injury
NCT05327829
Recruiting
This is a preliminary, prospective interventional study to investigate the feasibility of using transcutaneous alternating current stimulation (TACS) after a traumatic brain injury (TBI) to improve cognitive function and decision-making.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: TBI (Traumatic Brain Injury)
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Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy
NCT05167721
Recruiting
Multiple system atrophy (MSA) is a rare, rapidly progressive, and invariably fatal neurological condition characterized by autonomic failure, parkinsonism, and/or ataxia. There is no available treatment to slow or halt disease progression. The purpose of this study is to assess optimal dosing frequency, effectiveness and safety of adipose-derived autologous mesenchymal stem cells delivered into the spinal fluid of patients with MSA. Funding source: FDA Office of Orphan Product Development (OOPD... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
03/12/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Multiple System Atrophy
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An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
NCT04029337
Recruiting
Study to evaluate the feasibility, safety and performance of the HighLife trans-septal Transcatheter Mitral Valve in patients with moderate-severe and severe mitral regurgitation who are at high risk for surgical treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Minneapolis Heart, Minneapolis, Minnesota
Conditions: Mitral Regurgitation
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Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
NCT03851445
Recruiting
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Riverwood Healthcare Center, Aitkin, Minnesota
Conditions: Previously Treated Non-Small Cell Lung Cancer
Register for Updates
Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia
NCT02736695
Recruiting
This study is designed to learn more about overall tau burden in the brain of patients with Primary Progressive Aphasia (PPA) and Frontotemporal Dementia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Primary Progressive Aphasia, Behavioral Variant of Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant
Register for Updates
A Study of Pyridostigmine in Postural Tachycardia Syndrome
NCT00409435
Recruiting
This is a 3-day study comparing pyridostigmine versus placebo in the treatment of postural tachycardia syndrome (POTS). The researchers expect pyridostigmine to improve tachycardia and stabilize blood pressure.
Gender:
ALL
Ages:
Between 15 years and 55 years
Trial Updated:
03/12/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Postural Tachycardia Syndrome
Register for Updates
Biomarkers to Predict Cancer Therapy-related Cardiotoxicity
NCT06353191
Recruiting
This study evaluates why some cancer patients but not others experience changes in heart function following treatment with chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Register for Updates