There are currently 32 active clinical trials seeking participants for Fibromyalgia research studies. The states with the highest number of trials for Fibromyalgia participants are Florida, California, Ohio and Texas.
Supraspinal Processing of Sensory Aspects of Pain
NCT05814497
Recruiting
The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMR... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
06/26/2025
Locations: Cincinnati Children's Hospital, Cincinnati, Ohio
Conditions: Migraine in Children, Complex Regional Pain Syndromes, Musculoskeletal Pain, Functional Abdominal Pain Syndrome, Fibromyalgia
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Duloxetine Metabolism and Fibromyalgia
NCT06866444
Recruiting
People with fibromyalgia report generalized body pain ("pain all over"), increased sensitivity to painful stimulation, chronic tiredness or low energy, sleep problems, and other physical and functional problems. The exact cause of the disorder is poorly understood, and treatment can be difficult. The degree to which duloxetine is helpful for people with fibromyalgia varies greatly. For some people, it is very helpful for managing fibromyalgia symptoms. For others, people may not notice any bene... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2025
Locations: Pain Management Center and Pain Research Center at the University of Utah, Salt Lake City, Utah
Conditions: Fibromyalgia, Duloxetine
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Explosive Synchronization of Brain Network Activity in Chronic Pain
NCT04606095
Recruiting
This project is being conducted to evaluate the impact of explosive synchronization (ES) and its treatment with non-invasive brain stimulation in fibromyalgia (FM). The study design has three components, however, only 2 aims are enrolling participants. The first part (Aim1) is a cross sectional assessment of brain network explosive synchronization activity, connectivity, and response to pain in healthy controls and age and sex-matched fibromyalgia patients; the third part (Aim 3) is a longitudin... Read More
Gender:
ALL
Ages:
Between 19 years and 74 years
Trial Updated:
07/23/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Fibromyalgia, Healthy Volunteers
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Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
NCT04833465
Recruiting
The overarching goal of this study is the development of a physiologic endpoint of pain and treatment effect in three distinct rheumatology populations. This would enable objective assessment of pain and treatment in these populations and enable a much more precise approach to treatment. Such an endpoint stands to significantly improve outcomes in these patients by eliminating the need for a trial-and-error approach to treatment. This is a single site observational study that aims to collect ini... Read More
Gender:
ALL
Ages:
Between 5 years and 21 years
Trial Updated:
07/02/2025
Locations: Children's National Health System, Washington, District of Columbia
Conditions: Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Fibromyalgia
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Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
NCT05277025
Recruiting
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/17/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Fibromyalgia, Rheumatoid Arthritis
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Mindfulness Intervention for Fibromyalgia Delivered Through a Smartphone App
NCT07032519
Recruiting
The purpose of this pilot feasibility study is to evaluate the effects of a smartphone-based mindfulness intervention (MBI) on pain-related outcomes in individuals with fibromyalgia. This 8-week randomized controlled trial will compare an MBI app group to a control group who completes assessments only through the app. The MBI intervention includes weekly video content focused on mindfulness practice and psychoeducation, combined with daily symptom tracking through the app. Participants in both... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/15/2025
Locations: The Brigham and Women's Hospital Department of Anesthesiology, Boston, Massachusetts
Conditions: Fibromyalgia
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Fibromyalgia Sleep A to ZZZ Study
NCT06567886
Recruiting
This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Fibromyalgia
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Nitrous Oxide as Treatment for Fibromyalgia
NCT05357066
Recruiting
The purpose of this study is to explore a potential role of nitrous oxide in treating pain associated with fibromyalgia.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/05/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Fibromyalgia, Central Neuropathic Pain
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Effects of Breathing and Attention Training (BAT) on Pain Modulation
NCT05773482
Recruiting
The hypersensitivity of fibromyalgia is associated with abnormal pain modulation within the CNS, but not with peripheral or central sensitization. Many brain areas that contribute to modulation of pain are known, but their testing is complex and expensive. Quantitative sensory testing is easier to perform and repeatable. Therefore, it will be used to evaluate the effects of Breathing Attention Training (BAT) on the hypersensitivity of FM participants. BAT is a form of mindfulness meditation show... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/04/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Fibromyalgia
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The Effects of Core Shamanism in Fibromyalgia
NCT06579261
Recruiting
This study aims to determine the feasibility of a shamanism intervention for patients with fibromyalgia, acquire efficacy data to determine if Shamanism reduces clinical pain and other common symptoms associated with fibromyalgia, and determine if the Shamanism intervention changes heart rate electrocardiogram (ECG), breathing rate, and brain wave electroencephalogram (EEG) outcomes in fibromyalgia patients and shamanic practitioners. The investigators hypothesize that 80% of individuals will c... Read More
Gender:
FEMALE
Ages:
Between 18 years and 75 years
Trial Updated:
05/22/2025
Locations: Susan Samueli Integrative Health Institute, Irvine, California
Conditions: Fibromyalgia
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Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients
NCT06009159
Recruiting
Fibromyalgia (FM) is a syndrome with clinical symptoms involving multiple systems. The efficacy of current treatments is inadequate, and more alternative modalities are needed for the management of FM patients. The parasympathetic vagus nerve innervates and integrates sensory, motor, and autonomic systems and has been suggested to play a role in pain modulation. The role of vagus nerve stimulation (VNS) as a treatment option for FM patients is yet to be investigated. The investigators propose to... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/05/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Fibromyalgia
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Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture
NCT06571110
Recruiting
This study aims to see whether acupuncture can help fibromyalgia patients by giving them acupuncture treatment and seeing whether acupuncture helps enhance the effects of an opioid.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/31/2025
Locations: UCI Health Susan Samueli Integrative Health Institute, Irvine, California
Conditions: Fibromyalgia
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