North Carolina Clinical Trials

A listing of North Carolina Clinical Trials actively recruiting patient volunteers.

Charlotte, Raleigh, Asheville, and Wilmington are the key cities of North Carolina, with the Charlotte metro area alone holding about 2.56 million residents and attracting the most tourists each year. The state's diverse economy is driven in part on very high availability of hydroelectric power, and it has 15 metropolitan areas overall. Blue Ridge Parkway and Great Smoky Mountains National Park rank as the most visited national park and public land unit, respectively, in the whole United States. The 200-mile Outer Banks make up the most popular beaches. Duke University Hospital, a renowned academic medical center, has nearly 1,000 beds.

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2823 trials found

Featured Trials

A Vaccine Trials for Healthy Young Adults (18-30)

Recruiting

The Eclipse Trial is evaluating the safety and immune response of an investigational vaccine, called mRNA-1189, that may protect against mono.

Conditions: Healthy, Healthy Volunteer

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Featured Trials

A Vaccine Trial For Healthy Women Between 16-40

Recruiting

A Cytomegalovirus (CMV) Investigational Vaccine Clinical Trial for Healthy Women Age 16 to 40. Compensation included.

Conditions: Healthy Volunteers, Healthy

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RSV Vaccine For Adults 65+

Recruiting

The VANIR Study is a randomized, double-blind, phase 3 trial to assess the clinical efficacy and safety of the recombinant MVA-BN®-RSV vaccine in adults over 60.

Conditions: Healthy Volunteers, Healthy

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Myelofibrosis Clinical Trial

Recruiting

This clinical trial is testing an investigational drug called selinexor for adults with previously treated myelofibrosis.

Conditions: Primary Myelofibrosis (PMF), Myelofibrosis, Bone Marrow Cancer, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis, Secondary Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, Myelofibrosis (MF)

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Heart Failure Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an implantable investigational device called VITARIA for heart failure. Participants who qualify for the study will receive trial-related medical care, procedures, tests and study device at no cost.

Conditions: Heart Failure, Congestive Heart Failure, Chronic Heart Failure, Heart Failure, Congestive, Acute Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Acute Decompensated Heart Failure

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Narcolepsy Clinical Trial

Recruiting

This is a study evaluating the effectiveness of an investigational oral medication for adults with Narcolepsy. Participants who qualify for the study will receive trial-related medical care, tests and trial medication and may be compensated for time and travel.

Conditions: Narcolepsy, Sleep, Obstructive Sleep Apnea, Sleep Disorder

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PTSD Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational oral medication for post-traumatic stress disorder (PTSD). Participants who qualify for the study will receive trial-related procedures and study medication at no cost and may be compensated for time and travel.

Conditions: PTSD, Post-Traumatic Stress Disorder, Stress Disorders, Post-Traumatic, Post-Traumatic Stress Disorders, Stress, Anxiety, Anxiety Disorders

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Nash Clinical Trial

Recruiting

This is a clinical research study to test the safety and effectiveness of an investigational oral medication alongside an approved injectable diabetes medication for cirrhosis due to non-alcoholic steatohepatitis (NASH).

Conditions: NASH - Nonalcoholic Steatohepatitis, Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease, Fatty Liver, Nonalcoholic, Nonalcoholic Fatty Liver, Nonalcoholic Fatty Liver Disease (NAFLD), Steatohepatitis, Nonalcoholic, Non-Alcoholic Fatty Liver Disease, Fatty Liver, Non Alcoholic Fatty Liver Disease, Non Alcoholic Fatty Liver

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A mRNA Vaccine Trial for Adults

Recruiting

A clinical trial evaluating investigational mRNA vaccines in adults

Conditions: Healthy Volunteers

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Featured Trials

Low Testosterone Clinical Trial

Recruiting

This is a clinical research study to test the effects of three different FDA-approved testosterone products on blood pressure. Participants will receive trial-related medical care, tests and trial medication and may be compensated for time and travel.

Conditions: Low Testosterone, Hypogonadism, Testosterone Deficiency

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Featured Trials

A Vaccine Trial For Adults 50+

Recruiting

A clinical trial for an investigational respiratory syncytial virus (RSV) vaccine combined with an investigational COVID-19 booster vaccine for older adults.

Conditions: Healthy Volunteers, Healthy

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Featured Trials

Alzheimer's Disease Study

Recruiting

New research opportunity for people with mild cognitive impairment or early stage Alzheimer's.

Male & Female, 50-80 Years Old

Conditions: Alzheimers, Dementia

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Featured Trials

Parkinson's Research Opportunity

Recruiting

Take your place in a new project exploring the genetics of Parkinson’s. Join our Parkinson’s research for the chance to receive a free genetic test.

Conditions: Parkinson's Disease, Parkinson Disease, Idiopathic Parkinson's Disease

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Featured Trials

A Hodgkin Lymphoma (HL) Clinical Trial

Recruiting

A Study of Brentuximab Vedotin With Hodgkin Lymphoma (HL) and CD30-expressing Peripheral T-cell Lymphoma (PTCL)

Conditions: Hodgkin Lymphoma, Peripheral T Cell Lymphoma, T Cell Lymphoma, Hodgkin Disease, Recurrent Adult Hodgkin Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Recurrent Non-Hodgkin Lymphoma, Classical Hodgkin Lymphoma, Stage IV Adult Hodgkin Lymphoma, Peripheral T-cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, T-cell Lymphoma

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Featured Trials

A Myelofibrosis Treatment Clinical Trial

Recruiting

To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)

Conditions: Primary Myelofibrosis (PMF), Myelofibrosis, Bone Marrow Cancer, Primary Myelofibrosis, Post Essential Thrombocythemia Myelofibrosis, Post Polycythemia Vera Myelofibrosis

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Featured Trials

A Melanoma Treatment Clinical Trials

Recruiting

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

Conditions: Melanoma, Solid Tumor, NSCLC, Melanoma (Skin), Metastatic Melanoma, Malignant Melanoma, Solid Tumors, Advanced Solid Tumors, Advanced Solid Tumor, Non Small Cell, Non Small Cell Lung Carcinoma

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Featured Trials

A COVID-19 Vaccine Study For Teenagers

Recruiting

An investigational COVID-19 vaccine study for adolescents

Conditions: Healthy Volunteers

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Featured Trials

A Peripheral T Cell Lymphoma Clinical Trials

Recruiting

Assessing An Oral Janus Kinase Inhibitor, AZD4205 as Monotherapy in Patients Who Have PTCL (JACKPOT8)

Conditions: Peripheral T Cell Lymphoma (PTCL), Relapsed or Refractory

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Featured Trials

A Hodgkin Lymphoma (HL) + Peripheral T Cell Lymphoma Clinical Trial

Recruiting

A Study of Retreatment With Brentuximab Vedotin in Subjects With Classic Hodgkin Lymphoma or CD30-expressing Peripheral T Cell Lymphoma

Conditions: Hodgkin Lymphoma, Peripheral T Cell Lymphoma, Anaplastic Large Cell Lymphoma

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Featured Trials

A Diffuse Large B-Cell Lymphoma (DLBCL) Clinical Trial

Recruiting

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Conditions: Diffuse Large B-cell Lymphoma (DLBCL)

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Featured Trials

Meningitis Vaccine Clinical Studies for Ages 16-18

Recruiting

Help protect yourself and other teens and kids against meningitis by joining a clinical study!

Conditions: Healthy Volunteers

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Featured Trials

Meningitis Vaccine Clinical Studies for Ages 11-14

Recruiting

The purpose of this clinical study is to evaluate two different dosing schedules for an investigational meningococcal vaccine in preventing a meningitis infection in children, which is a serious and potentially life-threatening bacterial infection of the brain.

Conditions: Healthy Volunteers

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Featured Trials

Hepatitis B Clinical Studies

Recruiting

Hepatitis B Clinical Studies

Conditions: Hepatitis B

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Featured Trials

Asthma Clinical Studies

Recruiting

Asthma Clinical Studies

Conditions: Asthma

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Featured Trials

Clinical Studies for COPD

Recruiting

Clinical Studies for COPD

Conditions: COPD

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Featured Trials

Ulcerative Colitis Clinical Trials

Recruiting

Ulcerative Colitis Clinical Trials

Conditions: Ulcerative Colitis

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Featured Trials

Clinical Study for People at Risk of Developing Alzheimer's Disease

Recruiting

Clinical Studies for People at Risk of Developing Alzheimer's Disease

Conditions: Alzheimers, Dementia

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Featured Trials

Glaucoma Treatment Clinical Studies

Recruiting

The purpose of these clinical studies are to test the efficacy of treatments in reducing high eye pressure. You may qualify to participate if you have been diagnosed with open-angle glaucoma or ocular hypertension in one or both of your eyes.

Conditions: Glaucoma, Ocular Hypertension

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Web Based Orthopaedic Sports Medicine Registry

NCT01191151

The purpose of this study is to establish an international, web based clinical registry to collect baseline characteristics of patients undergoing orthopaedic, sports medicine, arthroscopy, and related surgery, and the subsequent outcomes and cost-effectiveness associated with the surgical procedures and nonoperative treatments.

Conditions: Degenerative and Traumatic Pathology of the Knee, Degenerative and Traumatic Pathology of the Shoulder and Elbow, Degenerative and Traumatic Pathology of the Foot and Ankle, Degenerative and Traumatic Pathology of the Hand and Wrist, Degenerative and Traumatic Pathology of the Hip

Phase: N/A

Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder

NCT01192568

This study will evaluate the safety and efficacy of Oxybutynin Chloride 10% Topical Gel in children 3 to less than 17 years old, who have overactive bladder due to a neurogenic condition. Children will be treated with 0.75 g of gel/day for two weeks. Patients will then return to the clinic for a potential dose titration. At this time their dose may be adjusted up to 1g/day, down to 0.5g/day, or remain the same at 0.75g of gel/day depending on the individual response and tolerability. The total t ...

Conditions: Overactive Detrusor, Neurogenic Bladder

Phase: Phase 4

Nephrotic Syndrome Study Network

NCT01209000

Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for approximately 12% of prevalent end stage renal disease (ESRD) cases (2005) at an annual cost in the US of more than $3 billion. However, the clinical classification of these diseases is widely believed to be inadequate by the scientific community. Given the poor understanding of MCD/FSGS and MN biology, it is not s ...

Conditions: Minimal Change Disease (MCD), Membranous Nephropathy, Glomerulosclerosis, Focal Segmental

Phase: N/A

Environmental Risk Factors for the Anti-synthetase Syndrome

NCT01276470

Background: Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors. Some researchers believe that people who are susceptible to autoimmune disorders develop them when the body reacts to environmental or other factors by creating white blood cells that attack the body s own tissues, which then progresses to autoimmune diseases. These immune-triggered disorders can overlap with one another to some extent, but most autoimmune ...

Conditions: Myositis, Dermatomyositis, Polymyositis, Juvenile Dermatomyositis, Juvenile Polymyositis

Phase: N/A

Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

NCT01280994

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the 129Xe apparent diffusion coefficient (ADC), and 3) imaging 129Xe that dissolves in the pulmonary blood and tissues upon inhalation. Such imaging of 129Xe gas transfer is expected to b ...

Conditions: Interstitial Lung Disease

Phase: Phase 2

Pharmacokinetics of Off Label Pediatric Medications

NCT01286519

The purpose of this study is to measure the level of medicines found in body fluids such as blood, urine, spinal fluid of children.

Conditions: Off Label Use of Medications in Pediatric Patients

Phase: N/A

S0820, Adenoma and Second Primary Prevention Trial

NCT01349881

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon or rectal cancer.

Conditions: Colorectal Neoplasms

Phase: Phase 3

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

NCT01351545

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.

Conditions: Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Severe Aplastic Anemia, Autoimmune Diseases

Phase: N/A

Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility

NCT01354002

The aims of this protocol are: to collect and store diseased and normal tissue and body fluid samples from new and returning patients at St. Jude Children's Research Hospital (SJCRH), affiliated sites and collaborating institutions; to collect and store samples from relatives of SJCRH patients; to collect and store retrospective and prospective pertinent corresponding clinical and laboratory data on disease characterization, treatment, and outcome; and to serve as a source of human biological sa ...

Conditions: Normal and Diseased Tissue and Body Fluids Samples

Phase: N/A

Caris Biorepository Research Protocol

NCT01499394

The Biorepository for Caris Life Sciences is designed for the purpose of making quality biospecimens and associated clinical data available for research studies related to advancing precision medicine and improving care for patients. The Caris Biorepository is a repository of prospectively collected biological specimens and associated clinical and demographic data gathered from multiple sources to be stored, used and shared for research. Caris Life Sciences will maintain the data and specimens ...

Conditions: Cancer

Phase: N/A

Inherited Reproductive Disorders

NCT01500447

Background: - During puberty, children begin to develop into adults. Problems with the hormones released during puberty can affect the reproductive system. Some people have low hormone levels that severely delay or prevent puberty. Others start puberty abnormally early. Other people may have a normal puberty but develop reproductive disorders later in life. Researchers want to study people with reproductive disorders to learn more about how these disorders may be inherited. Objectives: - To l ...

Conditions: Genetic Disorder, Infertility, Hypogonadism, Amenorrhea

Phase: N/A

Long-Term Safety Study Of Tofacitinib In Patients With Juvenile Idiopathic Arthritis

NCT01500551

Evaluate long-term safety and tolerability of tofacitinib in patients with JIA, who have previously participated in tofacitinib JIA studies.

Conditions: Juvenile Idiopathic Arthritis

Phase: Phase 3

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