North Carolina is currently home to 2740 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Winston-Salem, Charlotte and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Inspiring Seniors Toward Exercise Promotion
NCT06364189
Recruiting
The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults. Specific Aims are to determine (1) whether BMS beneficially influences PA behaviors and psychological responses to PA in older adults for 6 months, and (2) whether exercising with BMS differently influences physical and cognitive functioning as well as quality of life in older adults. To test the effects of BMS on PA, participants wil... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
04/12/2024
Locations: University of North Carolina at Greensboro, Greensboro, North Carolina
Conditions: Cognitively Normal Older Adults
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Psilocybin-Assisted Therapy in Treatment-Resistant Depression
NCT06303739
Recruiting
The goal of this clinical trial is to test how well psilocybin-assisted therapy works in treating people with depression. The main questions this study aims to answer are: Does psilocybin with assisted therapy help improve symptoms for people with depression? How long do the effects of this treatment last? Participants will: Take part in a couple of screening and preparation visits. Be given psilocybin in one or two treatment sessions. Attend a series of follow-up sessions over the following... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
04/12/2024
Locations: UNC Chapel Hill Medical Center, Chapel Hill, North Carolina
Conditions: Refractory Depression, Treatment Resistant Depression
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A Chronic Weight Management Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
NCT06143956
Recruiting
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for clinical testing.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/12/2024
Locations: Medication Management, Greensboro, North Carolina
Conditions: Obesity, Overweight
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The Diabetes Staging System in Patient Aligned Care Teams
NCT06142006
Recruiting
The purpose of this study is to examine the feasibility/acceptability of the Diabetes Staging System (DSS) in Patient Aligned Care Teams (PACT) teams and its ability to increase sodium-glucose cotransporter-2 inhibitor (SGLT2i) and glucagon-like-1 peptide (GLP-1) use in Veteran patients with type 2 diabetes and cardiovascular disease and/or chronic kidney disease.
Gender:
All
Ages:
Between 25 years and 75 years
Trial Updated:
04/12/2024
Locations: Greenville VA Health Care Center, 401 Moye Blvd, Greenville, North Carolina
Conditions: Diabetes Mellitus, Type 2 Diabetes
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A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis
NCT06130566
Recruiting
This is a parallel group, Phase 3, multinational, multicenter, randomized, double blind, placebo-controlled, 3-arm monotherapy study for treatment of participants diagnosed with moderate to severe atopic dermatitis (AD), whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for SC injection compared with placebo in participant... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
04/12/2024
Locations: Onsite Clinical Solutions, LLC - Piedmont Plastics & Dermatology Site Number : 8401124, Charlotte, North Carolina
Conditions: Dermatitis Atopic
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An Evaluation of Patient Reported Outcomes and Clinical Outcomes
NCT06092970
Recruiting
This extension study is being conducted to assess the following objectives through 12 months post-cardiac surgery: Patient reported outcomes (PRO), using the EQ-5D questionnaire Clinical outcomes
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Research Site, Raleigh, North Carolina
Conditions: Post-Operative Complications in Cardiac Surgery
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Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM
NCT06081894
Recruiting
This clinical trial will study the effects of aficamten (versus placebo) on the quality of life, exercise capacity, and clinical outcomes of patients with non-obstructive hypertrophic cardiomyopathy.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
04/12/2024
Locations: Sanger Heart & Vascular Institute - HCM Clinic, Charlotte, North Carolina
Conditions: Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
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Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa
NCT06079281
Recruiting
The primary objective of this study is to assess the efficacy of ALXN1850 versus placebo on functional outcomes in adolescent and adult participants with HPP who have not previously been treated with asfotase alfa.
Gender:
All
Ages:
Between 12 years and 130 years
Trial Updated:
04/12/2024
Locations: Research Site, Durham, North Carolina
Conditions: Hypophosphatasia
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Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates
NCT06075745
Recruiting
This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine pre-transplant. The primary objective is to assess the effect of pre-transplant (Tx) Triplex vaccination on duration of CMV antiviral therapy (AVT) within the first 100 days post-Tx in CMV seropositive donor (D+) and seronegative (R-) (D+R-) liver transplant recipients (... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Duke University School of Medicine, Durham, North Carolina
Conditions: Liver Transplant
Register for Updates
Effect of RBT-1 on Reducing the Risk of Post-Operative Complications in Subjects Undergoing Cardiac Surgery
NCT06021457
Recruiting
The purpose of this study is to evaluate the effect of RBT-1 on reducing the risk of post-operative complications in subjects undergoing cardiac surgery on cardiopulmonary bypass (CPB). A sub-study will also be conducted to evaluate the pharmacokinetic (PK) profile of a single administration of RBT-1 by means of a popPK approach in subjects scheduled to undergo cardiac surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Research Site, Raleigh, North Carolina
Conditions: Post-Operative Complications in Cardiac Surgery
Register for Updates
Estradiol Therapy In Transgender Women to Research Interactions With HIV Therapy
NCT06005610
Recruiting
Transgender women (TW) are a key population and priority for HIV treatment. More research is needed to develop evidence-based clinical guidance when it comes to choosing antiretroviral treatment (ART) regimens for TW on feminizing hormonal therapy (FHT). Concerns about ART interacting with FHT and decreasing its effectiveness can lead to decreased ART adherence and increased viral loads. The GET IT RiGHT trial aims to address concerns about drug-drug interactions (DDIs) between ART and FHT whil... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
04/12/2024
Locations: Chapel Hill CRS (3201), Chapel Hill, North Carolina
Conditions: HIV I Infection
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Horyzons: Implementation and Integration in Clinical Practice
NCT06002958
Recruiting
The primary aim of this trial is evaluating the barriers and enablers of implementing a digital intervention with both therapeutic content and social networking, Horyzons, as part of clinical care in first episode psychosis (FEP) clinics in North Carolina. Providers (clinicians and peers support specialists) will be recruited from FEP clinics to assess Horyzons implementation and integration within clinical care at three time points (baseline, 6 months, and 12 months). Further, individuals exper... Read More
Gender:
All
Ages:
Between 16 years and 35 years
Trial Updated:
04/12/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorder, Unspecified or Other Psychotic Disorders
Register for Updates