North Carolina is currently home to 2618 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
NCT05619289
Recruiting
The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question\[s\] it aims to answer are: * Is the clinical trial protocol feasible? * Is Vitamin D administration following burn injury safe? * How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
01/31/2025
Locations: University Of North Carolina, Chapel Hill, North Carolina
Conditions: Burn Injury, Chronic Pain
Register for Updates
A Study Assessing KB407 for the Treatment of Cystic Fibrosis
NCT05504837
Recruiting
This study will evaluate safety and tolerability of ascending doses of nebulized KB407 in adults with cystic fibrosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Cystic Fibrosis
Register for Updates
Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive to Complement Inhibitor Therapy
NCT04889430
Recruiting
The purpose of this Phase 3 study is to determine whether iptacopan (LNP023) is efficacious and safe for the treatment of aHUS in adult patients who are treatment naive to complement inhibitor therapy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/31/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Atypical Hemolytic Uremic Syndrome
Register for Updates
Immuno-Oncology Database and Bioregistry
NCT04656873
Recruiting
Immunotherapy, especially immune checkpoint inhibitors (ICIs), are effective in treating many different types of cancers. ICIs fight cancer by driving the immune system into an "activated state" that makes it harder for tumor cells to hide and easier for the immune system to destroy them. In doing this, oncologists risk "over activation" where immune cells can cause side effects that could affect any part of the body. These are known as immune related adverse events (irAEs). While irAEs are a kn... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina
Conditions: Malignancy, Immune System Diseases, Autoimmune Diseases
Register for Updates
Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study
NCT04207931
Recruiting
The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
01/31/2025
Locations: Wake Forest Baptist Health Department of Dermatology, Winston-Salem, North Carolina
Conditions: Central Centrifugal Cicatricial Alopecia (CCCA)
Register for Updates
A Study to Assess the Effects of Dexpramipexole in Participants with Eosinophilic COPD
NCT06533553
Recruiting
This is an open-label Phase II study assessing the PD of dexpramipexole 150 mg twice daily (BID) in participants with eosinophilic COPD. This study will help characterize the profile and duration of reductions of blood absolute eosinophil counts (AEC).
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
01/30/2025
Locations: Research US-10001-010, Charlotte, North Carolina
Conditions: Chronic Obstructive Pulmonary Disease
Register for Updates
A Portal-based Advance Care Planning Intervention Among Community-Dwelling Persons Living With Cognitive Impairment
NCT06509373
Recruiting
The purpose of this research is to examine the feasibility of using a patient portal based advance care planning (ACP) tool to improve ACP discussions and documentation in persons living with cognitive impairment in outpatient primary care.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
01/30/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Advanced Care Planning
Register for Updates
Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast Cancer
NCT06027268
Recruiting
The goal of this phase II study is to test the combination of trilaciclib, pembrolizumab, gemcitabine, and carboplatin in locally advanced unresectable or metastatic triple-negative breast cancer. The main questions it aims to answer are: * to evaluate the anti-cancer efficacy (assess how well it works) * to evaluate the safety and tolerability (how well the body can handle the treatment) of this combination of anti-cancer therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Metastatic Triple-Negative Breast Cancer
Register for Updates
The Bennett Kids PowerUP Project
NCT05858580
Recruiting
The study proposes a randomized pilot and feasibility study of a lifestyle modification program to promote healthy diet and activity in rural-dwelling children to reduce Type 2 Diabetes risks. Intervention participants will receive 6 months of programming to include: * 16 activity packs; * 9 health coach sessions; * unlimited access to a resource toolbox. Control participants will receive 6 activity packs promoting science, technology, engineering, and math (STEM) learning and 6 check-in call... Read More
Gender:
ALL
Ages:
Between 7 years and 10 years
Trial Updated:
01/30/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Obesity, Childhood, Type2diabetes
Register for Updates
Immune Signature Analysis of Disease Progression in Post Immunotherapy Lung Cancer Patients
NCT05415358
Recruiting
The purpose of this study is to examine the association between ctDNA/immune biomarkers and disease progression in patients who, at immunotherapy discontinuation, have completed at least 20 of an anticipated 24 months of immune checkpoint inhibitor monotherapy or immune checkpoint inhibitor combination chemotherapy for mNSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Atrium Health Levine Cancer, Charlotte, North Carolina
Conditions: Lung Cancer, Nonsmall Cell
Register for Updates
Safety and Preliminary Efficacy Trial of BNT142 in Patients with CLDN6-positive Solid Tumors
NCT05262530
Recruiting
This study is an open-label, multicenter, Phase I/IIa, dose escalation, safety, and pharmacokinetics (PK) study of BNT142 followed by expansion cohorts in patients with Claudin 6 (CLDN6)-positive advanced tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Solid Tumor
Register for Updates
A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
NCT05117476
Recruiting
CLN-619-001 is a Phase 1, open-label, multi-center study of CLN-619 alone and in combination with pembrolizumab in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Carolina BioOncology Institute, Huntersville, North Carolina
Conditions: Advanced Solid Tumor
Register for Updates