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North Carolina Paid Clinical Trials
A listing of 2642 clinical trials in North Carolina actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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North Carolina is currently home to 2642 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Offer
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Recruiting
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As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Efficacy and Safety of Iptacopan (LNP023) in Adult Patients With Atypical Hemolytic Uremic Syndrome Naive to Complement Inhibitor Therapy
Recruiting
The purpose of this Phase 3 study is to determine whether iptacopan (LNP023) is efficacious and safe for the treatment of aHUS in adult patients who are treatment naive to complement inhibitor therapy.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/31/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Atypical Hemolytic Uremic Syndrome
Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study
Recruiting
The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups
Gender:
FEMALE
Ages:
Between 18 years and 60 years
Trial Updated:
01/31/2025
Locations: Wake Forest Baptist Health Department of Dermatology, Winston-Salem, North Carolina
Conditions: Central Centrifugal Cicatricial Alopecia (CCCA)
A Portal-based Advance Care Planning Intervention Among Community-Dwelling Persons Living With Cognitive Impairment
Recruiting
The purpose of this research is to examine the feasibility of using a patient portal based advance care planning (ACP) tool to improve ACP discussions and documentation in persons living with cognitive impairment in outpatient primary care.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
01/30/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Advanced Care Planning
Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast Cancer
Recruiting
The goal of this phase II study is to test the combination of trilaciclib, pembrolizumab, gemcitabine, and carboplatin in locally advanced unresectable or metastatic triple-negative breast cancer.
The main questions it aims to answer are:
* to evaluate the anti-cancer efficacy (assess how well it works)
* to evaluate the safety and tolerability (how well the body can handle the treatment) of this combination of anti-cancer therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Metastatic Triple-Negative Breast Cancer
The Bennett Kids PowerUP Project
Recruiting
The study proposes a randomized pilot and feasibility study of a lifestyle modification program to promote healthy diet and activity in rural-dwelling children to reduce Type 2 Diabetes risks.
Intervention participants will receive 6 months of programming to include:
* 16 activity packs;
* 9 health coach sessions;
* unlimited access to a resource toolbox.
Control participants will receive 6 activity packs promoting science, technology, engineering, and math (STEM) learning and 6 check-in call... Read More
Gender:
ALL
Ages:
Between 7 years and 10 years
Trial Updated:
01/30/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Obesity, Childhood, Type2diabetes
Immune Signature Analysis of Disease Progression in Post Immunotherapy Lung Cancer Patients
Recruiting
The purpose of this study is to examine the association between ctDNA/immune biomarkers and disease progression in patients who, at immunotherapy discontinuation, have completed at least 20 of an anticipated 24 months of immune checkpoint inhibitor monotherapy or immune checkpoint inhibitor combination chemotherapy for mNSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Atrium Health Levine Cancer, Charlotte, North Carolina
Conditions: Lung Cancer, Nonsmall Cell
Safety and Preliminary Efficacy Trial of BNT142 in Patients with CLDN6-positive Solid Tumors
Recruiting
This study is an open-label, multicenter, Phase I/IIa, dose escalation, safety, and pharmacokinetics (PK) study of BNT142 followed by expansion cohorts in patients with Claudin 6 (CLDN6)-positive advanced tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Solid Tumor
A Study of CLN-619 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
Recruiting
CLN-619-001 is a Phase 1, open-label, multi-center study of CLN-619 alone and in combination with pembrolizumab in patients with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Carolina BioOncology Institute, Huntersville, North Carolina
Conditions: Advanced Solid Tumor
Testing the Causal Effects of a Civic Engagement Intervention on Health and Wellbeing Among Youth (I-ACTED)
Recruiting
The purpose of this research is to understand how participating or not participating in an action civics curriculum may affect the health and wellbeing of young people. Participants will be chosen from students who attend certain schools that choose to participate in the action civics curriculum. Participation in this research involves completing surveys during class time in the Spring and Fall 2021-2022 semesters and then completing online surveys outside of class in the future.
Gender:
ALL
Ages:
Between 10 years and 20 years
Trial Updated:
01/30/2025
Locations: Wake Forest School of Medicine, Winston-Salem, North Carolina
Conditions: Mental Health Wellness 1, Social Interaction, Health Attitude
Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)
Recruiting
Spinal muscular atrophy (SMA) is a neurogenetic disorder caused by a loss or mutation in the survival motor neuron 1 gene (SMN1) on chromosome 5q13, which leads to reduced SMN protein levels and a selective dysfunction of motor neurons. SMA is an autosomal recessive, early childhood disease with an incidence of 1:10,000 live births. SMA is the leading cause of infant mortality due to genetic diseases.
The purpose of this registry is to assess the long term outcomes of patients with SMA in the c... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/30/2025
Locations: Duke Health, Durham, North Carolina
Conditions: Spinal Muscular Atrophy (SMA)
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Recruiting
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival.
After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)
Recruiting
RATIONALE: The use of tailored axillary dissection as a tailored procedure will avoid surgical overtreatment by selectively removing the lymph nodes that are affected by the cancer, thereby sparing many women the unnecessary complications of a radical surgery, providing a better quality of life while keeping the same efficacy.
PURPOSE: The phase III trial is evaluating the optimal treatment for breast cancer patients in terms of surgery and radiotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Duke University/Duke Cancer Center, Durham, North Carolina
Conditions: Node-positive Breast Cancer