North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Selinexor With Combination With Induction/Consolidation Therapy in Acute Myeloid Leukemia Patients
NCT02835222
Recruiting
This pilot phase II trial studies how well selinexor works when given together with induction, consolidation, and maintenance therapy in treating older patients with acute myeloid leukemia. Selinexor may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cytarabine and daunorubicin hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stop... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Comprehensive Cancer Center of Wake Forest University, Winston-Salem, North Carolina
Conditions: Untreated Adult Acute Myeloid Leukemia
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A Study to Investigate the Immunogenicity, Reactogenicity, and Safety of mRNA-1083 (Influenza and COVID-19) Vaccine in Adults ≥18 to <65 Years of Age
NCT06864143
Recruiting
The purpose of this study is to evaluate the immunogenicity, reactogenicity, and safety, of mRNA-1083 multicomponent influenza and COVID-19 vaccine in adults ≥18 to \<65 years of age.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/19/2025
Locations: Trial Management Associates, LLC, Wilmington, North Carolina
Conditions: Influenza, SARS-CoV-2
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THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUSâ„¢) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension
NCT06559891
Recruiting
The primary objective of the THRIVE Pivotal study is to demonstrate the adjunctive effectiveness and the safety of the TIVUS system in: 1. subjects with hypertension (HTN) receiving up to 2 anti-hypertensive drugs of different classes in whom the anti-hypertensive medications will be stopped for a 4-week wash-out period before RDN/Sham procedure and during 2 months after procedure. 2. subjects with controlled hypertension receiving up to 2 anti-hypertensive drugs of different classes and who ac... Read More
Gender:
ALL
Ages:
Between 22 years and 75 years
Trial Updated:
03/19/2025
Locations: NC Heart and Vascular, Raleigh, North Carolina
Conditions: Hypertension
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Inspiring Seniors Towards Exercise Promotion to Protect Cognition
NCT06496425
Recruiting
The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults with subjective memory complaints. Specific Aims are to determine (1) whether BMS beneficially influences PA behaviors and psychological responses to PA in older adults for 6 months, and (2) whether exercising with BMS differently influences physical and cognitive functioning as well as quality of life in older adults.To test the effect... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
03/19/2025
Locations: UNC Greensboro, Greensboro, North Carolina
Conditions: Alzheimer Disease, Physical Activity
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D2C7-IT + 2141-V11 Combination Post-resection in RGBM
NCT06455605
Recruiting
The purpose of this study is to assess the safety and efficacy of the combination of D2C7-IT+2141-V11 administered in the non-enhancing tumor of patients with resected recurrent glioblastoma (rGBM) via convection enhanced delivery (CED), followed by subcutaneous cervical perilymphatic injections (CPLIs) of 2141-V11 2 and 4 weeks post infusion, then every 3 weeks for a year, and every 4-6 weeks thereafter if patients benefit from therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Recurrent Glioblastoma IDH Wildtype
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Metronidazole SC Penetrance With Moisturizers
NCT06434519
Recruiting
Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation. The purpose of this study is to assess the whether the common practice of applying moisturizer prior to topical metronidazole affects this medication's stratum corneum penetrance in rosacea patients. Participants will have one research office visit that will consist of having a randomly assigned... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/19/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Rosacea, Erythematotelangiectatic
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Project humAn dieTary daTa rEtuRN
NCT06266689
Recruiting
This study is designed to test the effects of diet data return on human dietary patterns. The investigators' working hypothesis is that returning diet data, collected via an empirical biomarker-based assessment method, will promote participant eating behavior changes towards a more healthful diet, and that these dietary patterns may also be reflected in the structure and function of the gut microbiome and in participant health outcomes. Here, the investigators will explore this hypothesis with p... Read More
Gender:
ALL
Ages:
12 months and below
Trial Updated:
03/19/2025
Locations: Duke University, Durham, North Carolina
Conditions: Diet Habit
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Androgens and NAFLD Longitudinal Cohort Study
NCT06124261
Recruiting
The researchers want to learn how androgens, a type of sex hormone, might affect nonalcoholic fatty liver (NAFLD) in young women over time. NAFLD happens when fat builds up in the liver which can cause damage to the liver such as inflammation or scarring. Young women with a condition called polycystic ovary syndrome (PCOS) have a high risk for NAFLD, and they often have high androgen levels too. So the researchers are recruiting young women with PCOS as well as those without PCOS, and will comp... Read More
Gender:
FEMALE
Ages:
Between 18 years and 42 years
Trial Updated:
03/19/2025
Locations: Duke University, Durham, North Carolina
Conditions: PCOS, NAFLD, NASH
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Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial
NCT06080698
Recruiting
The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream Infection (GN-BSI) is as effective but safer than remaining on intravenous (IV) antibiotic therapy for the duration of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Duke University, Durham, North Carolina
Conditions: Gram-negative Bacteremia
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Impact of Enhanced Daily Disinfection on Environmental Contamination in Hospital Rooms
NCT05739955
Recruiting
The purpose of this study is to determine if enhanced daily application of disinfectant with persistent 24-hour activity decreases the environmental bioburden compared to standard practice.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Duke University, Durham, North Carolina
Conditions: Disinfection
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Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity
NCT04427709
Recruiting
The purpose of this research is to evaluate the effects of oxytocin (naturally occurring hormone) given by an intramuscular (IM; into the muscle) injection, has on your parasympathetic nervous system. The parasympathetic nervous system is the part of the involuntary nervous system that is sometimes called the "rest and digest" system; the parasympathetic system conserves energy as it slightly slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gast... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/19/2025
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Chronic Pain, Osteoarthritis, Knee
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Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities
NCT04037527
Recruiting
The purpose of this Phase 1 research study is to obtain data or information on the safety and effectiveness of the combination of gemcitabine, docetaxel with radiation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina
Conditions: Soft Tissue Sarcoma
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