North Carolina is currently home to 2622 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)
NCT05945355
Recruiting
This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway Dysfunction (SAD) to obesity-related versus non-obesity-related asthma. The study will involve training (IT) for 8 weeks at three intensity levels (SHAM, low and high). Target dose: 150 inspirations t... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
11/12/2024
Locations: Duke Health Center Creekstone, Durham, North Carolina
Conditions: Asthma in Children, Obesity, Pediatric Obesity, Pediatric Asthma
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Yoga for Treatment of Overactive Bladder in Pediatric Patients
NCT05895045
Recruiting
The goal of this pilot study is to assess the impact of yoga as a treatment modality in pediatric patients age 8-18 diagnosed with idiopathic overactive bladder as measured by validated questionnaires and urinary biomarkers. The main question it aims to answer is: Does yoga help improve overactive bladder symptoms in this patient population? Participants will take part in a weekly yoga session for a total of 6 weeks with validated questionnaires and urinary samples for biomarkers to be completed... Read More
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
11/12/2024
Locations: Duke University Hospital, Durham, North Carolina
Conditions: Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
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Incremental Hemodialysis: The TwoPlus Trial
NCT05828823
Recruiting
This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function. The study will enroll 350 patients on chronic hemodialysis and 140 caregivers of enrolled patients. Patients will be randomized in 1:1 ratio to either incremental start hemodialysis or conventional hemodialysis. Caregivers will be followed along with patients... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: End-Stage Kidney Disease
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Finger Movement Training After Stroke
NCT05621980
Recruiting
Human development as a species has been strongly associated with the ability to dexterously manipulate objects and tools. Unfortunately, current therapy efforts typically fail to restore fine manual control after stroke. The goal of this study is to evaluate a new intervention that would combine targeted electrical stimulation of selected nerves with use a soft, pneumatically actuated hand exoskeleton to enhance repetitive practice of independent movements of the fingers and thumb in order to im... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/12/2024
Locations: Hand Rehabilitation Lab, Raleigh, North Carolina
Conditions: Stroke
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Inspiratory Pulmonary Rehabilitation for Children With Obesity and Asthma
NCT05608668
Recruiting
This is a single-center, randomized, SHAM-controlled, parallel assignment, double-masked,8-week interventional study among children aged 8-17 years (not yet 18 years old) of age with obesity and asthma. (n=60), recruited from Duke Health Center Creekstone, to test the effectiveness of inspiratory muscle rehabilitation (IMR) as an acceptable add-on intervention to reduce dyspnea (feeling short-of-breath or breathless) and to promote greater activity in children with obesity and asthma. Clinic to... Read More
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
11/12/2024
Locations: Duke Healthy Lifestyles Clinic, Durham, North Carolina
Conditions: Pediatric Obesity, Pediatric Asthma
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IL13 Signaling in Allergic Asthma
NCT05478824
Recruiting
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic and non-allergic patients with asthma and obesity and drive significant differential responses to dupilumab. It is further hypothesized that dupilumab will increase interleukin-13 receptor alpha 2 (IL-13Rα2) levels and/or signaling activity on airway epithelial cells iso... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/12/2024
Locations: Duke Asthma Allergy and Airway Center, Durham, North Carolina
Conditions: Asthma, Allergic, Asthma, Obesity
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High Dose Inspiratory Muscle Training in LOPD
NCT05431127
Recruiting
Study Objectives: 1) assess the safety and feasibility of high-dose inspiratory muscle training (IMT) delivered remotely in Late-onset Pompe Disease (LOPD) and 2) determine its effects on respiratory and patient-reported outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Late-Onset Pompe Disease, Lysosomal Disease
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Xenon MRI Pulm Hypertension
NCT04991454
Recruiting
The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hemodynamics (monitored with 129Xe MRI/MRS) and how these signals change with disease progression or treatment.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/12/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Pulmonary Hypertension, Pulmonary Arterial Hypertension
Register for Updates
Perioperative Evaluation of Cerebellar Tumors
NCT04463979
Recruiting
This is a prospective, cohort study to evaluate the impact of cerebellar functional topography on perioperative outcomes related to cognition and motor ataxia in patients with cerebellar tumors.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/12/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cerebellar Tumors, Brain Tumor
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Extension Study to Evaluate the Long-Term Safety and Tolerability of MBX 2109 in Patients With Hypoparathyroidism
NCT06531941
Recruiting
The purpose of this study is to evaluate the long-term safety and tolerability of MBX 2109 in patients with hypoparathyroidism who completed the 12-week treatment period in the Phase 2 study, MBX-2H1002.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/11/2024
Locations: MBX Biosciences Investigational Site, Greenville, North Carolina
Conditions: Hypoparathyroidism
Register for Updates
Phase 2 Study of AFM13 in Combination with AB-101 in Subjects with R/R HL and CD30+ PTCL
NCT05883449
Recruiting
AFM13-203 is a phase 2, open-label, multi-center, multi-cohort study with a safety run-in followed by expansion cohorts. The study is evaluating the safety and efficacy of AFM13 in combination with AB-101 in subjects with R/R classical HL and CD30-positive PTCL.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/11/2024
Locations: UNC Immunotherapy Team, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Relapsed or Refractory Hodgkin Lymphoma, Peripheral T Cell Lymphoma
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Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy
NCT05793151
Recruiting
The goal of this clinical trial is to compare the effectiveness of a navigation-based multilevel intervention (ENDURE) with treatment as usual to improve the initiation of guideline-adherent postoperative radiation therapy among patients with head and neck cancer. The main questions the trial aims to answer are: * Does ENDURE improve initiation of timely PORT relative to treatment as usual? * Does ENDURE improve initiation of timely PORT in regards to racial disparities relative to treatment as... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/11/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oropharynx Cancer, Oral Cavity Cancer, Larynx Cancer
Register for Updates