North Carolina is currently home to 2622 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
9-ING-41 in Pediatric Patients with Refractory Malignancies.
NCT04239092
Recruiting
9-ING-41 has anti-cancer clinical activity with no significant toxicity in adult patients. This Phase 1 study will study its efficacy in paediatric patients with advanced malignancies.
Gender:
ALL
Ages:
22 years and below
Trial Updated:
11/07/2024
Locations: Levine Cancer Center, Charlotte, North Carolina
Conditions: Refractory Cancer, Refractory Neoplasm, Cancer Pediatric, Refractory Tumor, Pediatric Cancer, Pediatric Brain Tumor, Neuroblastoma, Neuroblastoma Recurrent, Pediatric Lymphoma, Pediatric Meningioma, Diffuse Intrinsic Pontine Glioma
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Healthy Heart Habits-2
NCT06440278
Recruiting
Sixty adults who have experienced acute coronary syndrome within the past 2-12 months from three states (Rhode Island, North Carolina, Minnesota) will be randomized to either (1) a coaching program for depressed mood and health behavior change (Behavioral Activation for Health and Depression; BA-HD), or (2) Enhanced Usual Care. This study will evaluate the feasibility and acceptability of study procedures and BA-HD, and establish protocol and measurement harmonization across three sites in prepa... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/05/2024
Locations: ECU Health, Greenville, North Carolina
Conditions: Acute Coronary Syndrome
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The ACES Study for Aseptic Pleural Effusion
NCT06210685
Recruiting
The study will enroll recurrent aseptic pleural effusion patients who are designated by their physician as needing treatment to control the fluid. Baseline assessment will include a history and physical, chest imaging and quality of life questionnaires. After ACES implantation, patients will remain under hospital care for general observation as per standard-of-care before being discharged home with access to electronic diaries for tracking pain and dyspnea.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: University of North Carolina Pulmonary and Critical Care Medicine, Chapel Hill, North Carolina
Conditions: Pleural Effusion
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Cardiovascular Effects of Very Low Nicotine Content Cigarettes
NCT05707871
Recruiting
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Tobacco Use
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Evaluation of Fluoxetine and Cytotoxic Lysosomal Stress in Glioma (FLIRT)
NCT05634707
Recruiting
The purpose of this research study is to determine if fluoxetine increases lysosomal stress in patients with recurrent IDHwt glioma by evaluating LAMP1 expression in tumor samples obtained pre-resection via biopsy and during surgery. Lysosomes are organelles (structures in cells) that contain digestive enzymes (substances that break down chemicals) that help keep the cells free of extra or worn out cell parts. Fluoxetine, a drug approved by the FDA to treat problems like depression and anxiety,... Read More
Gender:
ALL
Ages:
24 years and above
Trial Updated:
11/05/2024
Locations: The Preston Robert Tisch Brain Tumor Center at Duke University, Durham, North Carolina
Conditions: Primary Brain Tumor, Brain Tumor, Recurrent
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Patient Specific Talus Spacer Post Approval Study
NCT05364606
Recruiting
Humanitarian Device Exemption Approved Patient Specific Talus Spacer Post Approval Study.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/05/2024
Locations: Duke Orthopeadics Arringdon, Morrisville, North Carolina
Conditions: Avascular Necrosis of the Talus
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NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations
NCT04815278
Recruiting
The proposed study, NC Works4Health (NCW4H), builds on the strengths of long-standing academic-community research partnerships between this UNC at Chapel Hill (UNC) team of investigators and key stakeholders across health, social service, employment, and economic development sectors. The overall goal of this study is to test the effectiveness of a multilevel intervention that can be readily adopted by communities to reduce chronic disease risks in socioeconomically disadvantaged populations by (... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
11/05/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Diabetes, Chronic Disease, Psychological Distress
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Study to Test AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) in Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)
NCT04315324
Recruiting
This phase II trial studies how well OBI-3424 works in treating patients with T-cell acute lymphoblastic leukemia that has come back (relapsed) or does not response to treatment (refractory). Drugs used in chemotherapy, such as OBI-3424, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. OBI-3424 may reduce the amount of leukemia in the body.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/05/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Recurrent T Acute Lymphoblastic Leukemia, Refractory T Acute Lymphoblastic Leukemia
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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry
NCT02418442
Recruiting
Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
11/05/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Rheumatic Joint Disease
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Study to Assess Real-world Effectiveness of Belimumab for Treatment of Adults With LN
NCT06527872
Recruiting
The purpose of the OBSErve-LN study is to assess the real-world use and effectiveness of belimumab in routine practice for the treatment of adults with active LN in multiple countries of interest. This study aims to provide the first long-term (up to 5 years) assessment of renal function preservation in belimumab treated participants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: GSK Investigational Site, Charlotte, North Carolina
Conditions: Lupus Nephritis
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Detection and Risk Stratification in Veterans Presenting with Microscopic Hematuria
NCT05889195
Recruiting
It is of current debate whether the use of invasive (referring to a process that requires insertion into the body) standard of care procedures such as a cystoscopy which is a procedure to look inside the bladder using a thin camera called a cystoscope, is appropriate for use in patients with microscopic hematuria or blood in urine invisible to the naked eye. This is because the risk of disease (bladder cancer - urothelial carcinoma) is relatively low in this population group, approximately 3%. I... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Durham VA Health Care System, Durham, North Carolina
Conditions: Urothelial Carcinoma
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Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
NCT05863195
Recruiting
This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread to the liver (liver metastases) and cannot be removed by surgery (unresectable). HAI uses a catheter to carry a tumor-killing chemotherapy drug called floxuridine directly into the liver. HAI is already approved by the Food and Drug Administration (FDA) for use in metas... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Stage IV Colorectal Cancer AJCC v8, Unresectable Colorectal Carcinoma
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