North Carolina is currently home to 2641 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only
NCT05619588
Recruiting
The objectives of this study are to evaluate the performance and safety of the Vantage Total Ankle System. This study will follow subjects for a period of up to 10 years post-surgery.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/26/2025
Locations: Duke Department of Orthopaedic Surgery, Durham, North Carolina
Conditions: Ankle Rheumatoid Arthritis, Arthritis of Ankle, Failure, Prosthesis
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Exactech Shoulder Post Market Clinical Follow-up Study
NCT05603728
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/26/2025
Locations: Southeastern Sports Medicine and Orthopedics, Asheville, North Carolina
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
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Child-Adult Relationship Enhancement in Primary Care (PriCARE) / Criando Niños Con CARIÑO (CARIÑO)
NCT05233150
Recruiting
The purpose of this study is evaluate the effectiveness of PriCARE/CARIÑO to reduce child maltreatment, improve parent-child interactions, and reduce harsh/neglectful parenting, parent stress, and child behaviors.
Gender:
ALL
Ages:
Between 18 months and 99 years
Trial Updated:
02/26/2025
Locations: University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: Parent-Child Relations, Child Maltreatment
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Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease
NCT05150197
Recruiting
The purpose of this study is to test a new way of measuring the peripheral vision (called a visual field test) using a device which can be worn as goggles rather than being a large instrument the patient must sit at. This new visual field test (called VisuALL) is an FDA-approved virtual reality system which has been used in adults and children. This study will compare the performance of the VisuALL to the standard testing for peripheral vision, which is called the Humphrey Visual Field (HVF) tes... Read More
Gender:
ALL
Ages:
4 years and above
Trial Updated:
02/26/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Visual Field Defect, Peripheral
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Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
NCT04427384
Recruiting
The objectives of this registry study are to evaluate real-world clinical outcomes and patient reported outcomes that measure the effectiveness and safety of STaRT.
Gender:
ALL
Ages:
All
Trial Updated:
02/26/2025
Locations: University of North Carolina Health, Chapel Hill, North Carolina
Conditions: Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary, Brain Tumor - Metastatic, Brain Tumor, Adult: Glioblastoma, Brain Tumor, Adult Meningioma
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Dissolved Phase HXe-129 MRI: a Novel Biomarker to Quantify Pulmonary Pathology in Young Healthy E-cigarette Users
NCT06856525
Recruiting
A two-center, longitudinal assessment of 40 electronic cigarette users and 40 healthy controls at the initial visit and a follow-up visit 12 months later. This study will determine the impact of electronic cigarette use on pulmonary gas exchange capacity and then corroborate the Hyperpolarized Xenon MRI (HXeMRI) results with the cardiopulmonary stress test at the initial visit and a follow-up visit 12 months later.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
02/25/2025
Locations: Duke University, Durham, North Carolina
Conditions: Electronic Cigarette Related Lung Damage
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FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
NCT06724406
Recruiting
The goal of this clinical trial is to learn the best combination of family components that yields optimal weight loss among Black adults. The main question it aims to answer is: What combination of four family components in combination with a standard behavioral weight loss program yields optimal weight loss among Black adults? Researchers will compare different combinations of family skills components (communication content, cohesion content, number of sessions, and mode of delivery) to see th... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/25/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Obesity and Overweight, Diabetes Mellitus, Weight Loss, Behavior Change
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Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
NCT06636721
Recruiting
The purpose of this study is to develop a brief assessment and need-based behavioral intervention for addressing aging-specific concerns in older adults with lung cancer. The long-term goals of this research include identifying the unique concerns of these patients, providing patients with behavioral skills to address their symptom management needs, and enhancing patient engagement with healthcare specialties targeting aging-specific concerns. In the first phase of this study, participants (12... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/25/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: Lung Cancer
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Contraceptive Efficacy Study of Ovaprene
NCT06127199
Recruiting
This will be a multi-center, single arm, open-label study of Ovaprene, a non-hormonal intravaginal ring, to investigate the contraceptive effectiveness, safety and acceptability of Ovaprene.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
02/25/2025
Locations: Carolina Women's Research and Wellness Center, Durham, North Carolina
Conditions: Contraception
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129Xe MRI Cardiopulmonary
NCT06038630
Recruiting
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension, Acute Pulmonary Embolism, Anemia, Polycythemia, Dyspnea
Register for Updates
uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto
NCT05874921
Recruiting
The purpose of this registry is to evaluate real world experience and outcomes of patients with Upper Tract Urothelial Cancer (UTUC) treated with Jelmyto in the United States.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: The University of North Carolina Chapel Hill, Chapel Hill, North Carolina
Conditions: Urothelial Carcinoma, Urothelial Carcinoma Recurrent, Urothelial Carcinoma Ureter, Urothelial Carcinoma Ureter Recurrent, Urothelial Cancer of Renal Pelvis, Urothelial Carcinoma of the Renal Pelvis and Ureter, Carcinoma, Transitional Cell, Transitional Cell Carcinoma of Renal Pelvis
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Amplatzer Amulet LAAO Vs. NOAC
NCT04226547
Recruiting
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy. The clinical investigation is a prospective, randomized, multicenter active control worldwide trial. Subjects will be randomized in a 1:1 ratio between the Amulet LAA occlusion device ("Device Group") and a commercially available NOAC medication ("Cont... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Mission Health & Hospitals, Asheville, North Carolina
Conditions: Atrial Fibrillation, Stroke, Bleeding
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