North Carolina is currently home to 2633 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Optimize Pediatric OCT Imaging
NCT06139523
Recruiting
Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an investigational noncontact OCT system (Duke Biomedical Engineering) to assess their ability to image the pediatric retina. The investigators hypothesize that the contact OCT system is superior in imaging larger areas of the retina (larger field-of-view), while it has similar resolut... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/08/2024
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Retinal Disease, Glaucoma, Optic Nerve Diseases
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Sling vs No Sling After Reverse Total Shoulder Arthroplasty
NCT06092996
Recruiting
This study involves patients who will be undergoing a reverse total shoulder replacement at Duke University. 100 eligible will be randomly assigned into one of two groups, a sling or no sling group. Patients in the sling group will wear a sling for three weeks after their surgery while the no sling group will only wear a sling three days after their surgery. Patients will follow their doctors normal follow up visit schedule after surgery, with visits at 2 weeks, 6 weeks, 3 months, 6 months, 1 ye... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Shoulder Disease, Rotator Cuff Tear Arthropathy, Shoulder Osteoarthritis
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Imaging Retinal Vasculature in Infant Eyes
NCT05558059
Recruiting
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed in infants with retinopathy of prematurity. However, how these blood vessels form during development of the human fovea remains unclear. This research will advance our understanding of the fundamental knowledge of how the blood vessels around the fovea form in infants,... Read More
Gender:
ALL
Ages:
2 months and below
Trial Updated:
10/08/2024
Locations: Duke University, Durham, North Carolina
Conditions: Retinopathy of Prematurity
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Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
NCT05055830
Recruiting
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating provider. The purpose of this study is to characterize the PK of drugs routinely administered to children per standard of care using opportunistic and scavenged samples. The prescribing of drugs to children will not be part of this protocol. After the child/adult (\<21 years of... Read More
Gender:
ALL
Ages:
Between 0 months and 20 years
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cardiac Disease, Critically Ill, Children, Adult
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Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: Naval Medical Center Camp Lejeune, Camp Lejeune, North Carolina
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma
NCT04657146
Recruiting
The main goal of this study is to provide foundational data to drive translational approaches for an entirely novel category of immunotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Glioblastoma
Register for Updates
Written Exposure Therapy to Improve Recovery Among Sexual Assault Survivors
NCT06571513
Recruiting
The main objective of this pilot trial is to determine the feasibility and initial efficacy of telehealth-delivered written exposure therapy to reduce the development of posttraumatic stress disorder after sexual assault. This pilot trial will provide the data necessary to design and support a large-scale trial.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Post-traumatic Stress Disorder
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Behavioral Approaches to Reduce Diabetes Distress in Adults With Type 1 Diabetes: A Pragmatic SMART
NCT06405373
Recruiting
This study is designed to compare two behavioral approaches to reduce diabetes distress ("the expected burdens, concerns, fears, and threats that arise from the challenges of living with diabetes") in adults with type 1 diabetes. At the study baseline, participants will be randomized to take part in one of two virtual, group-based interventions (the "Primary" intervention) utilizing either an emotions-focused or a problem-solving approach to reduce diabetes distress. After the initial interventi... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
10/07/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Diabetes type1, Diabetes Mellitus, Type 1, Diabetes, Autoimmune, Diabetes Mellitus, Distress, Emotional
Register for Updates
Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
NCT06399302
Recruiting
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure
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A Study to Assess the Safety, Pharmacokinetics, and Efficacy of Intravenous (IV) ABBV-303, as Monotherapy and in Combination With IV Infused Budigalimab (ABBV-181), in Adults With Advanced Solid Tumors
NCT06158958
Recruiting
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess safety, tolerability, pharmacokinetics and preliminary efficacy of ABBV-303 as a monotherapy and in combination with budigalimab, (ABBV-181). ABBV-303 is an investigational drug being developed for the treatment of solid tumors. There are multiple treatment arms in this study. Participants will either receive ABBV-303 as a single agent or in combination with bud... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Carolina BioOncology Institute /ID# 254305, Huntersville, North Carolina
Conditions: Solid Tumors
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CIED Infection Quality Initiative Demonstration Project
NCT05471973
Recruiting
The aim of this Quality Initiative (QI) demonstration project is to develop a model to increase guideline-driven care for patients with cardiovascular implantable electronic devices (CIED) infection. Multidisciplinary teams will be established to carry out the multifaceted intervention. This program seeks to improve early identification and diagnosis, appropriate treatment, and faster time to treatment of CIED infection.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Infections
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Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies
NCT04919018
Recruiting
Though common, morbidities related to upper airway disease in primary ciliary dyskinesia (PCD) and primary immunodeficiencies (PID) have not been fully characterized. These conditions can be difficult to distinguish due to their overlapping phenotypes. The sinonasal and middle ear features are often identified as most problematic by patients and their families, and optimal, highly effective treatment regimens have not been established. The main objective of this project is to characterize and co... Read More
Gender:
ALL
Ages:
Between 5 years and 45 years
Trial Updated:
10/07/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Primary Ciliary Dyskinesia, Kartagener Syndrome, Primary Immune Deficiency
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