North Carolina is currently home to 2617 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Eye Plaque Brachytherapy for Ocular Melanoma
NCT06432660
Recruiting
This prospective registry study will evaluate doses utilized in eye plaque brachytherapy for the treatment of ocular melanoma and their associated outcomes. The goal of this study is to evaluate if lower doses of radiation can maintain high local control rates while minimizing the toxicities related to radiation therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Ocular Melanoma
Register for Updates
Evaluating Treatments for Suicidal Veterans With PTSD
NCT05974631
Recruiting
Posttraumatic Stress Disorder (PTSD) is a significant driver of suicide risk among Veterans, but there is a critical knowledge gap about how to treat PTSD among people at elevated risk for suicide. Although evidence-based treatments for PTSD reduce suicide risk, Veterans at high risk for suicidal behavior rarely receive these potentially life-saving treatments. Prior research suggests that a treatment that combines Dialectical Behavior Therapy (DBT) with the DBT Prolonged Exposure protocol (DBT... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Self-directed Violence, Post-traumatic Stress Disorder (PTSD)
Register for Updates
Project HOPE 1000: Health Outcomes Pregnancy Exposures
NCT04417283
Recruiting
The purpose of this study is to collect biological samples from pregnant women and their babies and to collect data on long-term health, school outcomes, and the use of state and county services. The information learned from this study may help identify important factors that may influence the health of mothers and babies, both short-and long-term.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/16/2024
Locations: Duke affiliated ObGyn clinics within Duke Health, Durham, North Carolina
Conditions: Pregnant
Register for Updates
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome
NCT03865589
Recruiting
To perform an receiver operating characteristic (ROC) analysis, define a threshold and quantify the sensitivity and specificity of US SWE for risk stratification of patients into three categories as defined by the European Bone Marrow Transplant (EBMT) adult and pediatric criteria: no sinusoidal obstruction syndrome (SOS), mild to moderate SOS, and severe to very severe SOS. Secondarily, the investigators would also like to quantify the temporal relationship between US SWE changes and SOS diagno... Read More
Gender:
ALL
Ages:
Between 1 month and 99 years
Trial Updated:
07/16/2024
Locations: Duke University, Durham, North Carolina
Conditions: Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic, Stem Cell Transplant Complications
Register for Updates
BiVACOR® Total Artificial Heart Early Feasibility Study
NCT06174103
Recruiting
The purpose of this study is to assess the feasibility of using the BiVACOR Total Artificial Heart (TAH) System to support adult patients with severe biventricular heart failure, or univentricular heart failure in which left ventricular assist device (LVAD) support is not recommended, who require mechanical circulatory support to sustain life. The BiVACOR TAH System is intended for use as a bridge to transplant (BTT). Feasibility will be assessed by evaluating safety and performance of the BiVAC... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/12/2024
Locations: Duke University Hospital, Durham, North Carolina
Conditions: Heart Failure, Biventricular Failure
Register for Updates
A Phase 2 Study of VLX-1005 Versus Placebo in Suspected Heparin Induced Thrombocytopenia
NCT05785819
Recruiting
The purpose of this study is to evaluate the efficacy and safety of VLX-1005, a 12-lipoxygenase (12-LOX) enzyme inhibitor in treating heparin induced thrombocytopenia (HIT). Participants with suspected HIT will receive the usual standard of care, and will be assigned randomly to either VLX-1005 or placebo treatment. The study will measure important outcomes including platelet count, stroke, pulmonary embolus (clot to the lungs) and bleeding.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/12/2024
Locations: Duke University, Durham, North Carolina
Conditions: Thrombocytopenia, Immune, Heparin Induced Thrombocytopenia
Register for Updates
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
NCT04373317
Recruiting
Patients with Parkinson's disease (PD) sometimes experience symptoms affecting their movement, such as slowness, tremor, stiffness, and balance or walking problems. Many patients also have other symptoms not related to movement, called non-motor symptoms, which may affect one's mood or emotions, memory or thinking, or cause one to see or hear things that aren't real (hallucinations) or believe things that aren't true (delusions). Hallucinations or delusions, together called psychosis, occur in u... Read More
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/12/2024
Locations: Asheville VA Medical Center, Asheville, NC, Asheville, North Carolina
Conditions: Parkinson's Disease Psychosis
Register for Updates
Creating Access to Resources and Economic Support
NCT05971160
Recruiting
The goal of this study is to test the ability of small grants and/or peer support to improve mental health among transgender people experiencing material hardship. The main questions the study will answer are: 1. Do microgrants with or without peer mentoring improve mental health? 2. Do microgrants with or without peer mentoring improve mental health by reducing material hardship and/or increasing a sense of community connection? Researchers will compare mental health outcomes among three grou... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2024
Locations: Duke University (online recruitment), Durham, North Carolina
Conditions: Psychological Distress
Register for Updates
Device Global Registry for the IlluminOss Bone Stabilization System
NCT05206981
Recruiting
This is a multi-center, observational patient registry. The primary objective of the study is to collect safety and performance data on the IlluminOss Device when used to provide stabilization and alignment for the treatment of traumatic or impending and pathologic fractures.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
07/11/2024
Locations: Mission Hospital, Asheville, North Carolina
Conditions: Traumatic Fracture, Pathological Fracture
Register for Updates
Clinical Trial for Surgery of the Ulnar Nerve (SUN) at the Elbow
NCT04254185
Recruiting
This research is studying two surgical procedures in a large group of people to learn about how well these procedures work as a treatment for ulnar neuropathy at the elbow (UNE). Researchers want to see which surgery is more helpful for people with ulnar neuropathy. This research will determine if one surgery is better than the other to alleviate symptoms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2024
Locations: OrthoCarolina Research Institute, Inc., Charlotte, North Carolina
Conditions: Neuropathy Ulnar
Register for Updates
The Intra-arterial Vasospasm Trial
NCT01996436
Recruiting
The primary objective of the study is to determine the optimal intra-arterial drug treatment regimen for arterial lumen restoration post cerebral vasospasm following aneurysmal subarachnoid hemorrhage. The secondary objective is to evaluate clinical outcome at 90 days post discharge following optimal intra-arterial drug treatment for cerebral vasospasm. We hypothesize that Intra-arterial (IA) infusion of a combination of multiple vasodilators is more efficacious than single agent treatment cere... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/11/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Cerebral Vasospasm
Register for Updates
Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study
NCT06072547
Recruiting
The goal of this clinical trial is to learn about the role of flavored on!® nicotine pouch products (the research products), an oral tobacco-leaf-free product, in the replacement of cigarettes with the use of the research products among adults who smoke cigarettes. The main question it aims to answer is whether flavored (vs. non-flavored) research products generate greater reduction of cigarette smoking among adults who smoke cigarettes. Participants will be provided with research products to u... Read More
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
07/10/2024
Locations: Rose Research Center, Raleigh, North Carolina
Conditions: Cigarette Smoking Behavior
Register for Updates