North Carolina is currently home to 2644 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Charlotte, Winston-Salem and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Predictors of Pain in Sickle Cell Disease
NCT06139510
Recruiting
Sickle cell disease is a painful inherited disorder that affects approximately 100,000 people in the United States, and more than half of these individuals develop chronic or persistent pain that is often severe and disabling. The factors that predict whether an individual with sickle cell disease will develop severe, disabling pain are unclear. The goal of this project is to identify the factors that predict severe pain outcomes in individuals living with sickle cell disease in order to improve... Read More
Gender:
ALL
Ages:
Between 15 years and 40 years
Trial Updated:
09/06/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Sickle Cell Disease, Chronic Pain
Register for Updates
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
NCT05625360
Recruiting
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving wellbeing after surgery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/05/2024
Locations: Atrium Health - Levine Cancer Institute, Charlotte, North Carolina
Conditions: Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance, Malignant Female Reproductive System Neoplasm
Register for Updates
The Validation Study of Bioelectronics
NCT05397951
Recruiting
The purpose of this study is to investigate the safe wearability and basic functions of the multi-modality sensors fabricated in the PI lab.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
09/05/2024
Locations: Kenan Laboratories at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Healthy, Health Behavior
Register for Updates
Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers
NCT06196008
Recruiting
This clinical trial compares telephone-based physical activity coaching to self monitored physical activity for improving physical function in older adults who are undergoing surgery for lung cancer and their caregivers. Lung cancer surgery in older adults is associated with functional declines and unique challenges. Performing physical activity around the time of surgery has been shown to improve functional outcomes in patients and exercise programs delivered via telehealth may improve access a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Duke University, Durham, North Carolina
Conditions: Lung Carcinoma
Register for Updates
Randomized Study of the pdSTIM™ System (Phrenic Nerve to Diaphragm STIMulation) in Failure to Wean Mechanically Ventilated Patients
NCT05998018
Recruiting
This prospective, multi-center, randomized, controlled clinical trial is being conducted to evaluate the safety and efficacy of the pdSTIM System to facilitate weaning from mechanical ventilation through phrenic nerve stimulation. Potential subjects who are on mechanical ventilation for at least four days and have failed at least one weaning attempt will be considered for the study. Those enrolled will be randomized in a 1:1 manner between the treatment group that is standard of care with the pd... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Ventilator Induced Diaphragm Dysfunction
Register for Updates
JuggerStitch Post Market Clinical Follow-up Study
NCT04228367
Recruiting
This study is a post-market follow-up study. The data collected from this study will serve the purpose of confirming the safety and performance of the JuggerStitch Device used for meniscal repair according to the product labelling (Instruction For Use).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: OrthoCarolina, Charlotte, North Carolina
Conditions: Meniscus Tear, Tibial, Meniscus Lesion
Register for Updates
Neuroblastoma Biology Study
NCT01587300
Recruiting
Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma... Read More
Gender:
ALL
Ages:
Between 31 days and 99 years
Trial Updated:
09/01/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Neuroblastoma
Register for Updates
Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
NCT02237872
Recruiting
The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/30/2024
Locations: Biomedical Research Imaging Center, Chapel Hill, North Carolina
Conditions: Obesity
Register for Updates
Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
NCT02220426
Recruiting
The primary goal of this study is to evaluate the feasibility of detecting Brown Adipose Tissue (BAT) in healthy subjects by using hyperpolarized xenon gas MRI. In this pilot study, MRI of BAT of healthy adult volunteers will be performed at 3 Tesla to assess image quality using a prototype surface coil and pulse sequence following inhalation of hyperpolarized 129Xe (xenon) gas at thermoneutrality and under mild cold condition. The investigators are testing the abilities of xenon MRI to see br... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/30/2024
Locations: Biomedical Research Imaging Center, Chapel Hill, North Carolina
Conditions: Obesity
Register for Updates
A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors
NCT05593094
Recruiting
This will be a Phase 1, multicenter, open-label trial to evaluate the safety, tolerability, PK and efficacy of ZN-A-1041 as a monotherapy or in combination in patients with HER2-positive advanced solid tumors with or without brain metastases. The study will consist of three phases: Phase 1a (dose escalation with ZN-A-1041 monotherapy), Phase 1b (dose escalation with ZN-A-1041 combination therapy) and Phase 1c (dose expansion with ZN-A-1041 combination therapy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/29/2024
Locations: Duke Cancer Institute, Durham, North Carolina
Conditions: Advanced Solid Tumors, HER2-positive Breast Cancer
Register for Updates
Early Patient Removal of Urinary Catheters After Urogynecologic Surgery
NCT06344884
Recruiting
Management of postoperative urinary retention often requires the use of indwelling catheters. In a previous study, the investigators determined that patient removal of catheters at home is non-inferior to standard office removal on postoperative day three or four (POD3-4). The purpose of this study is to determine whether patient removal of catheters at home on postoperative day one (POD1) is noninferior to removal on POD 3-4.
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
08/27/2024
Locations: UNC Health Rex, Raleigh, North Carolina
Conditions: Urinary Retention Postoperative, Postoperative Urinary Tract Infection, Catheter Site Pain
Register for Updates
An Adaptive Prenatal Intervention to Increase Childhood Vaccinations
NCT05795855
Recruiting
This study will test whether proactively connecting expectant parents with factual vaccination information during pregnancy can build confidence in vaccinations and lead to timely vaccinations during pregnancy and once their child is born.
Gender:
FEMALE
Ages:
All
Trial Updated:
08/27/2024
Locations: Duke Health System, Durham, North Carolina
Conditions: Vaccination Refusal
Register for Updates